Accurate evaluation of QT interval in conscious rhesus monkeys (Macaca mulatta) by use of Holter ECG
The aim of this study was to determine the best method to evaluate the QT interval with respect to the heart rate in rhesus monkeys. Rhesus monkeys (Macaca mulatta) are widely used in cardiovascular research, but the characteristics of QT-RR formulas as regards rhesus monkeys has not been sufficient...
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| Veröffentlicht in: | Journal of electrocardiology 2002-10, Vol.35 (4), p.333-342 |
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| creator | Hassimoto, Masatoshi Harada, Takuma Kaga, Nobuhiko Murano, Hiroyuki Obata, Masaomi |
| description | The aim of this study was to determine the best method to evaluate the QT interval with respect to the heart rate in rhesus monkeys. Rhesus monkeys (Macaca mulatta) are widely used in cardiovascular research, but the characteristics of QT-RR formulas as regards rhesus monkeys has not been sufficiently related. We analyzed the physiological QT-RR relation for practical evaluation of the QT interval in conscious rhesus monkeys by use of 24-h Holter ECG monitoring. As the QT interval varies with dependency on the RR interval, 14 QT regression functions were evaluated by use of about 50 pairs of QT-RR points per animal in 5 male rhesus monkeys. The accuracy of fit with the measured data was assessed according to the minimum Akaike information criterion. Among one-parameter linear regression functions, QT = a [times ] (RR)[frac12], where [ldquo ]a[rdquo ] is the regression coefficient, gave the best fit, which was almost comparable to that of all multi-parameter regression functions. Our results also suggest that the QTc formula derived from the square root regression function is the most practical for evaluation of QT intervals in rhesus monkeys. In conclusion, concerning the heart rate of rhesus monkeys, we propose the modification of Bazett's formula (QTc = QT [times ] (500)[frac12]/(RR)[frac12], where the dimension of RR and QT interval is milliseconds). We believe the information herein is quite useful for cardiovascular studies on rhesus monkeys. |
| doi_str_mv | 10.1054/jelc.2002.35846 |
| format | Article |
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Rhesus monkeys (Macaca mulatta) are widely used in cardiovascular research, but the characteristics of QT-RR formulas as regards rhesus monkeys has not been sufficiently related. We analyzed the physiological QT-RR relation for practical evaluation of the QT interval in conscious rhesus monkeys by use of 24-h Holter ECG monitoring. As the QT interval varies with dependency on the RR interval, 14 QT regression functions were evaluated by use of about 50 pairs of QT-RR points per animal in 5 male rhesus monkeys. The accuracy of fit with the measured data was assessed according to the minimum Akaike information criterion. Among one-parameter linear regression functions, QT = a [times ] (RR)[frac12], where [ldquo ]a[rdquo ] is the regression coefficient, gave the best fit, which was almost comparable to that of all multi-parameter regression functions. Our results also suggest that the QTc formula derived from the square root regression function is the most practical for evaluation of QT intervals in rhesus monkeys. In conclusion, concerning the heart rate of rhesus monkeys, we propose the modification of Bazett's formula (QTc = QT [times ] (500)[frac12]/(RR)[frac12], where the dimension of RR and QT interval is milliseconds). We believe the information herein is quite useful for cardiovascular studies on rhesus monkeys.</description><identifier>ISSN: 0022-0736</identifier><identifier>EISSN: 1532-8430</identifier><identifier>DOI: 10.1054/jelc.2002.35846</identifier><identifier>PMID: 12395361</identifier><identifier>CODEN: JECAB4</identifier><language>eng</language><publisher>Orlando, FL: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Circadian Rhythm - physiology ; Consciousness - physiology ; Electrocardiography, Ambulatory ; Electrocardiography. Vectocardiography ; Electrodiagnosis. Electric activity recording ; Electrophysiologic Techniques, Cardiac ; Heart Conduction System - physiology ; Heart Rate - physiology ; Investigative techniques, diagnostic techniques (general aspects) ; Japan ; Linear Models ; Macaca mulatta ; Male ; Medical sciences ; Models, Animal ; Models, Cardiovascular</subject><ispartof>Journal of electrocardiology, 2002-10, Vol.35 (4), p.333-342</ispartof><rights>2002</rights><rights>2003 INIST-CNRS</rights><rights>Copyright Churchill Livingstone Inc., Medical Publishers Oct 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-6596f053a69584fdbe61e72816b2ebc90e023a99447138c54cb7eba8f5c3db5a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/216195474?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13997412$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12395361$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hassimoto, Masatoshi</creatorcontrib><creatorcontrib>Harada, Takuma</creatorcontrib><creatorcontrib>Kaga, Nobuhiko</creatorcontrib><creatorcontrib>Murano, Hiroyuki</creatorcontrib><creatorcontrib>Obata, Masaomi</creatorcontrib><title>Accurate evaluation of QT interval in conscious rhesus monkeys (Macaca mulatta) by use of Holter ECG</title><title>Journal of electrocardiology</title><addtitle>J Electrocardiol</addtitle><description>The aim of this study was to determine the best method to evaluate the QT interval with respect to the heart rate in rhesus monkeys. Rhesus monkeys (Macaca mulatta) are widely used in cardiovascular research, but the characteristics of QT-RR formulas as regards rhesus monkeys has not been sufficiently related. We analyzed the physiological QT-RR relation for practical evaluation of the QT interval in conscious rhesus monkeys by use of 24-h Holter ECG monitoring. As the QT interval varies with dependency on the RR interval, 14 QT regression functions were evaluated by use of about 50 pairs of QT-RR points per animal in 5 male rhesus monkeys. The accuracy of fit with the measured data was assessed according to the minimum Akaike information criterion. Among one-parameter linear regression functions, QT = a [times ] (RR)[frac12], where [ldquo ]a[rdquo ] is the regression coefficient, gave the best fit, which was almost comparable to that of all multi-parameter regression functions. Our results also suggest that the QTc formula derived from the square root regression function is the most practical for evaluation of QT intervals in rhesus monkeys. In conclusion, concerning the heart rate of rhesus monkeys, we propose the modification of Bazett's formula (QTc = QT [times ] (500)[frac12]/(RR)[frac12], where the dimension of RR and QT interval is milliseconds). We believe the information herein is quite useful for cardiovascular studies on rhesus monkeys.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Circadian Rhythm - physiology</subject><subject>Consciousness - physiology</subject><subject>Electrocardiography, Ambulatory</subject><subject>Electrocardiography. Vectocardiography</subject><subject>Electrodiagnosis. Electric activity recording</subject><subject>Electrophysiologic Techniques, Cardiac</subject><subject>Heart Conduction System - physiology</subject><subject>Heart Rate - physiology</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Japan</subject><subject>Linear Models</subject><subject>Macaca mulatta</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Models, Animal</subject><subject>Models, Cardiovascular</subject><issn>0022-0736</issn><issn>1532-8430</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kEtr3DAURkVpaCbTrrsropCQLjzRW9YyDHkUEkohXQtZvqaa2lYi2YH599F0BgKBoMUVl6OPTwehr5SsKJHiYgO9XzFC2IrLWqgPaEElZ1UtOPmIFmXPKqK5OkYnOW8IIYZp9gkdU8aN5IouUHvp_ZzcBBieXT-7KcQRxw7_fsBhnCCVZblgH8fsQ5wzTn8hlzHE8R9sMz6_d74cPMy9myb3AzdbPGfYRdzGvgTgq_XNZ3TUuT7Dl8Ncoj_XVw_r2-ru183P9eVd5YVSU6WkUR2R3ClTPtO1DSgKmtVUNQwabwgQxp0xQmjKay-FbzQ0ru6k520jHV-is33uY4pPM-TJDiF76Hs3QuluNZNUacYL-P0NuIlzGks3y6iiRgotCnSxh3yKOSfo7GMKg0tbS4nd2bc7-3Zn3_63X158O8TOzQDtK3_QXYDTA-Cyd32X3OhDfuW4MVoUeonMnoNi6zlAssU-jB7akMBPto3h3RIv_ZKflA</recordid><startdate>20021001</startdate><enddate>20021001</enddate><creator>Hassimoto, Masatoshi</creator><creator>Harada, Takuma</creator><creator>Kaga, Nobuhiko</creator><creator>Murano, Hiroyuki</creator><creator>Obata, Masaomi</creator><general>Elsevier Inc</general><general>Churchill Livingstone</general><general>Elsevier Science Ltd</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7X8</scope></search><sort><creationdate>20021001</creationdate><title>Accurate evaluation of QT interval in conscious rhesus monkeys (Macaca mulatta) by use of Holter ECG</title><author>Hassimoto, Masatoshi ; Harada, Takuma ; Kaga, Nobuhiko ; Murano, Hiroyuki ; Obata, Masaomi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-6596f053a69584fdbe61e72816b2ebc90e023a99447138c54cb7eba8f5c3db5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Circadian Rhythm - physiology</topic><topic>Consciousness - physiology</topic><topic>Electrocardiography, Ambulatory</topic><topic>Electrocardiography. Vectocardiography</topic><topic>Electrodiagnosis. Electric activity recording</topic><topic>Electrophysiologic Techniques, Cardiac</topic><topic>Heart Conduction System - physiology</topic><topic>Heart Rate - physiology</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Japan</topic><topic>Linear Models</topic><topic>Macaca mulatta</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Models, Animal</topic><topic>Models, Cardiovascular</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hassimoto, Masatoshi</creatorcontrib><creatorcontrib>Harada, Takuma</creatorcontrib><creatorcontrib>Kaga, Nobuhiko</creatorcontrib><creatorcontrib>Murano, Hiroyuki</creatorcontrib><creatorcontrib>Obata, Masaomi</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of electrocardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hassimoto, Masatoshi</au><au>Harada, Takuma</au><au>Kaga, Nobuhiko</au><au>Murano, Hiroyuki</au><au>Obata, Masaomi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Accurate evaluation of QT interval in conscious rhesus monkeys (Macaca mulatta) by use of Holter ECG</atitle><jtitle>Journal of electrocardiology</jtitle><addtitle>J Electrocardiol</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>35</volume><issue>4</issue><spage>333</spage><epage>342</epage><pages>333-342</pages><issn>0022-0736</issn><eissn>1532-8430</eissn><coden>JECAB4</coden><abstract>The aim of this study was to determine the best method to evaluate the QT interval with respect to the heart rate in rhesus monkeys. Rhesus monkeys (Macaca mulatta) are widely used in cardiovascular research, but the characteristics of QT-RR formulas as regards rhesus monkeys has not been sufficiently related. We analyzed the physiological QT-RR relation for practical evaluation of the QT interval in conscious rhesus monkeys by use of 24-h Holter ECG monitoring. As the QT interval varies with dependency on the RR interval, 14 QT regression functions were evaluated by use of about 50 pairs of QT-RR points per animal in 5 male rhesus monkeys. The accuracy of fit with the measured data was assessed according to the minimum Akaike information criterion. Among one-parameter linear regression functions, QT = a [times ] (RR)[frac12], where [ldquo ]a[rdquo ] is the regression coefficient, gave the best fit, which was almost comparable to that of all multi-parameter regression functions. Our results also suggest that the QTc formula derived from the square root regression function is the most practical for evaluation of QT intervals in rhesus monkeys. In conclusion, concerning the heart rate of rhesus monkeys, we propose the modification of Bazett's formula (QTc = QT [times ] (500)[frac12]/(RR)[frac12], where the dimension of RR and QT interval is milliseconds). We believe the information herein is quite useful for cardiovascular studies on rhesus monkeys.</abstract><cop>Orlando, FL</cop><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>12395361</pmid><doi>10.1054/jelc.2002.35846</doi><tpages>10</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Circadian Rhythm - physiology Consciousness - physiology Electrocardiography, Ambulatory Electrocardiography. Vectocardiography Electrodiagnosis. Electric activity recording Electrophysiologic Techniques, Cardiac Heart Conduction System - physiology Heart Rate - physiology Investigative techniques, diagnostic techniques (general aspects) Japan Linear Models Macaca mulatta Male Medical sciences Models, Animal Models, Cardiovascular |
| title | Accurate evaluation of QT interval in conscious rhesus monkeys (Macaca mulatta) by use of Holter ECG |
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