Formation of Adenine−N3/Guanine−N7 Cross-Link in the Reaction of trans-Oriented Platinum Substrates with Dinucleotides

The reactions of the anticancer complex trans-[PtCl2{(E)-HNC(OMe)Me}2] (trans-EE) with a series of ribo and deoxyribodinucleotides have been studied by HPLC and 2D [1H, 15N] HMQC NMR spectroscopy and compared with those of the inactive trans isomer of cisplatin, trans-[PtCl2(NH3)2] (trans-DDP). Rea...

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Veröffentlicht in:	Journal of the American Chemical Society 2002-10, Vol.124 (43), p.12854-12862
Hauptverfasser:	Liu, Yangzhong, Vinje, Jo, Pacifico, Concetta, Natile, Giovanni, Sletten, Einar
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - chemistry Adenine - metabolism Analytical chemistry Chemistry Chromatographic methods and physical methods associated with chromatography Chromatography, High Pressure Liquid Cisplatin - chemistry Cisplatin - metabolism Cisplatin - pharmacology Cross-Linking Reagents - chemistry Cross-Linking Reagents - metabolism Cross-Linking Reagents - pharmacology Deoxyadenine Nucleotides - chemistry Deoxyguanosine - chemistry dinucleotides DNA - chemistry DNA - drug effects DNA - metabolism Exact sciences and technology Guanine - chemistry Guanine - metabolism Hydrogen-Ion Concentration Kinetics Models, Molecular Nitrogen Isotopes Nuclear Magnetic Resonance, Biomolecular - methods Other chromatographic methods Spectrometric and optical methods
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