Cholic acid mediates negative feedback regulation of bile acid synthesis in mice

Cholesterol is converted into dozens of primary and secondary bile acids through pathways subject to negative feedback regulation mediated by the nuclear receptor farnesoid X receptor (FXR) and other effectors. Disruption of the sterol 12alpha-hydroxylase gene (Cyp8b1) in mice prevents the synthesis...

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Veröffentlicht in:	The Journal of clinical investigation 2002-10, Vol.110 (8), p.1191-1200
Hauptverfasser:	Li-Hawkins, Jia, Gåfvels, Mats, Olin, Maria, Lund, Erik G, Andersson, Ulla, Schuster, Gertrud, Björkhem, Ingemar, Russell, David W, Eggertsen, Gosta
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Bile Bile Acids and Salts - biosynthesis Bile Acids and Salts - chemistry Biomedical research Cholesterol Cholesterol - metabolism Cholesterol 7-alpha-Hydroxylase - genetics Cholesterol 7-alpha-Hydroxylase - metabolism Cholic Acid - metabolism Cholic Acid - pharmacology DNA-Binding Proteins - metabolism Enzymes Feedback Female Gene Deletion Gene Expression - drug effects Liver Male Mice Mice, Inbred C57BL Mice, Knockout Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism Regulation RNA, Messenger - genetics RNA, Messenger - metabolism Small intestine Steroid 12-alpha-Hydroxylase - deficiency Steroid 12-alpha-Hydroxylase - genetics Sterols Transcription Factors - metabolism
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