SERUM LEPTIN CONCENTRATIONS DURING THE PERINATAL PERIOD
ABSTRACT We aimed to study maternal and infant serum leptin concentrations during the perinatal period and their relationship to the body weight of mothers and newborns. Serum leptin values were measured by enzyme-linked immunoadsorbent assay (ELISA) (R&D systems) in 26 healthy, term neonates du...
Gespeichert in:
| Veröffentlicht in: | American journal of perinatology 2000, Vol.17 (6), p.325-328 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 328 |
|---|---|
| container_issue | 6 |
| container_start_page | 325 |
| container_title | American journal of perinatology |
| container_volume | 17 |
| creator | Sarandakou, Angeliki Protonotariou, Efthimia Rizos, Dimitrios Malamitsi-Puchner, Ariadne Giannaki, Galini Phocas, Iphigenia Creatsas, George |
| description | ABSTRACT
We aimed to study maternal and infant serum leptin concentrations during the perinatal period and their relationship to the body weight of mothers and newborns. Serum leptin values were measured by enzyme-linked immunoadsorbent assay (ELISA) (R&D systems) in 26 healthy, term neonates during the first (N1) and fifth (N5) day after birth and were compared with serum leptin values in maternal blood (MS), amniotic fluid (AF), and umbilical cord (UC) at delivery. Twenty-five healthy, nonpregnant women, age and body weight-matched to the mothers, were used as controls (C). Infant serum leptin concentrations declined significantly after birth from UC to the N5 samples (P < 0.003). MS leptin values were significantly higher than UC, N1, N5, and C values (P < 0.001), while AF values were significantly lower than in controls (P < 0.001). UC, but not MS leptin values correlated significantly with the birth weight of infants (R = 0.6; P < 0.03). The elevated values of leptin in maternal serum and the regressing pattern of infant leptin values after birth suggest an additional, probably placental source of this protein during pregnancy, possibly contributing to the regulation of fetal body weight. |
| doi_str_mv | 10.1055/s-2000-13438 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72514740</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72514740</sourcerecordid><originalsourceid>FETCH-LOGICAL-c417t-f52580199bace27895aad0adecb12bc790c2a13500e7e9a4991fec43508181043</originalsourceid><addsrcrecordid>eNptkE1PwkAQhjdGI4jePJsmJl60OtPusttjUyo0wZZAOW-WZRshLWCXHvz3lo_oxdO8mTx5Z_IQco_wisDYm3U9AHDRp764IF2EQLiCC3ZJusB95mLfxw65sXYNgJ4AcU06iEipj_0u4bN4Ov9wxvEkT1InytIoTvNpmCdZOnMG82mSDp18FDuTuI1hHo6PKRvckqtCldbcnWePzN_jPBq542yYROHY1RT53i2YxwRgECyUNh4XAVNqCWpp9AK9heYBaE-hzwAMN4GiQYCF0bRdCBQI1O-Rp1Pvrt5-NcbuZbWy2pSl2phtYyX3GFJOoQVfTqCut9bWppC7elWp-lsiyIMoaeVBlDyKavGHc2-zqMzyDz6baYHHM6CsVmVRq41e2V9O-BzY4b3nE7X_XJnKyPW2qTetj_-P_gAfCHZI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72514740</pqid></control><display><type>article</type><title>SERUM LEPTIN CONCENTRATIONS DURING THE PERINATAL PERIOD</title><source>MEDLINE</source><source>Thieme Connect Journals</source><creator>Sarandakou, Angeliki ; Protonotariou, Efthimia ; Rizos, Dimitrios ; Malamitsi-Puchner, Ariadne ; Giannaki, Galini ; Phocas, Iphigenia ; Creatsas, George</creator><creatorcontrib>Sarandakou, Angeliki ; Protonotariou, Efthimia ; Rizos, Dimitrios ; Malamitsi-Puchner, Ariadne ; Giannaki, Galini ; Phocas, Iphigenia ; Creatsas, George</creatorcontrib><description>ABSTRACT
We aimed to study maternal and infant serum leptin concentrations during the perinatal period and their relationship to the body weight of mothers and newborns. Serum leptin values were measured by enzyme-linked immunoadsorbent assay (ELISA) (R&D systems) in 26 healthy, term neonates during the first (N1) and fifth (N5) day after birth and were compared with serum leptin values in maternal blood (MS), amniotic fluid (AF), and umbilical cord (UC) at delivery. Twenty-five healthy, nonpregnant women, age and body weight-matched to the mothers, were used as controls (C). Infant serum leptin concentrations declined significantly after birth from UC to the N5 samples (P < 0.003). MS leptin values were significantly higher than UC, N1, N5, and C values (P < 0.001), while AF values were significantly lower than in controls (P < 0.001). UC, but not MS leptin values correlated significantly with the birth weight of infants (R = 0.6; P < 0.03). The elevated values of leptin in maternal serum and the regressing pattern of infant leptin values after birth suggest an additional, probably placental source of this protein during pregnancy, possibly contributing to the regulation of fetal body weight.</description><identifier>ISSN: 0735-1631</identifier><identifier>EISSN: 1098-8785</identifier><identifier>DOI: 10.1055/s-2000-13438</identifier><identifier>PMID: 11144316</identifier><identifier>CODEN: AJPEEK</identifier><language>eng</language><publisher>New York, NY: Thieme</publisher><subject>Adult ; Amniotic Fluid - chemistry ; Biological and medical sciences ; Enzyme-Linked Immunosorbent Assay ; Female ; Fetal Blood - chemistry ; Gynecology. Andrology. Obstetrics ; Humans ; Infant, Newborn - blood ; Leptin - blood ; Management. Prenatal diagnosis ; Medical sciences ; Perinatal Care ; Pregnancy - blood ; Pregnancy. Fetus. Placenta ; Reference Values ; Sensitivity and Specificity ; Statistics, Nonparametric</subject><ispartof>American journal of perinatology, 2000, Vol.17 (6), p.325-328</ispartof><rights>Copyright © 2000 by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA. Tel.: +1(212) 584-4662</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-f52580199bace27895aad0adecb12bc790c2a13500e7e9a4991fec43508181043</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2000-13438.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2000-13438$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,780,784,3017,3018,4024,27923,27924,27925,54559,54560</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=837054$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11144316$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sarandakou, Angeliki</creatorcontrib><creatorcontrib>Protonotariou, Efthimia</creatorcontrib><creatorcontrib>Rizos, Dimitrios</creatorcontrib><creatorcontrib>Malamitsi-Puchner, Ariadne</creatorcontrib><creatorcontrib>Giannaki, Galini</creatorcontrib><creatorcontrib>Phocas, Iphigenia</creatorcontrib><creatorcontrib>Creatsas, George</creatorcontrib><title>SERUM LEPTIN CONCENTRATIONS DURING THE PERINATAL PERIOD</title><title>American journal of perinatology</title><addtitle>Amer J Perinatol</addtitle><description>ABSTRACT
We aimed to study maternal and infant serum leptin concentrations during the perinatal period and their relationship to the body weight of mothers and newborns. Serum leptin values were measured by enzyme-linked immunoadsorbent assay (ELISA) (R&D systems) in 26 healthy, term neonates during the first (N1) and fifth (N5) day after birth and were compared with serum leptin values in maternal blood (MS), amniotic fluid (AF), and umbilical cord (UC) at delivery. Twenty-five healthy, nonpregnant women, age and body weight-matched to the mothers, were used as controls (C). Infant serum leptin concentrations declined significantly after birth from UC to the N5 samples (P < 0.003). MS leptin values were significantly higher than UC, N1, N5, and C values (P < 0.001), while AF values were significantly lower than in controls (P < 0.001). UC, but not MS leptin values correlated significantly with the birth weight of infants (R = 0.6; P < 0.03). The elevated values of leptin in maternal serum and the regressing pattern of infant leptin values after birth suggest an additional, probably placental source of this protein during pregnancy, possibly contributing to the regulation of fetal body weight.</description><subject>Adult</subject><subject>Amniotic Fluid - chemistry</subject><subject>Biological and medical sciences</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Fetal Blood - chemistry</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infant, Newborn - blood</subject><subject>Leptin - blood</subject><subject>Management. Prenatal diagnosis</subject><subject>Medical sciences</subject><subject>Perinatal Care</subject><subject>Pregnancy - blood</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Reference Values</subject><subject>Sensitivity and Specificity</subject><subject>Statistics, Nonparametric</subject><issn>0735-1631</issn><issn>1098-8785</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1PwkAQhjdGI4jePJsmJl60OtPusttjUyo0wZZAOW-WZRshLWCXHvz3lo_oxdO8mTx5Z_IQco_wisDYm3U9AHDRp764IF2EQLiCC3ZJusB95mLfxw65sXYNgJ4AcU06iEipj_0u4bN4Ov9wxvEkT1InytIoTvNpmCdZOnMG82mSDp18FDuTuI1hHo6PKRvckqtCldbcnWePzN_jPBq542yYROHY1RT53i2YxwRgECyUNh4XAVNqCWpp9AK9heYBaE-hzwAMN4GiQYCF0bRdCBQI1O-Rp1Pvrt5-NcbuZbWy2pSl2phtYyX3GFJOoQVfTqCut9bWppC7elWp-lsiyIMoaeVBlDyKavGHc2-zqMzyDz6baYHHM6CsVmVRq41e2V9O-BzY4b3nE7X_XJnKyPW2qTetj_-P_gAfCHZI</recordid><startdate>2000</startdate><enddate>2000</enddate><creator>Sarandakou, Angeliki</creator><creator>Protonotariou, Efthimia</creator><creator>Rizos, Dimitrios</creator><creator>Malamitsi-Puchner, Ariadne</creator><creator>Giannaki, Galini</creator><creator>Phocas, Iphigenia</creator><creator>Creatsas, George</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2000</creationdate><title>SERUM LEPTIN CONCENTRATIONS DURING THE PERINATAL PERIOD</title><author>Sarandakou, Angeliki ; Protonotariou, Efthimia ; Rizos, Dimitrios ; Malamitsi-Puchner, Ariadne ; Giannaki, Galini ; Phocas, Iphigenia ; Creatsas, George</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-f52580199bace27895aad0adecb12bc790c2a13500e7e9a4991fec43508181043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Amniotic Fluid - chemistry</topic><topic>Biological and medical sciences</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Fetal Blood - chemistry</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infant, Newborn - blood</topic><topic>Leptin - blood</topic><topic>Management. Prenatal diagnosis</topic><topic>Medical sciences</topic><topic>Perinatal Care</topic><topic>Pregnancy - blood</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Reference Values</topic><topic>Sensitivity and Specificity</topic><topic>Statistics, Nonparametric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sarandakou, Angeliki</creatorcontrib><creatorcontrib>Protonotariou, Efthimia</creatorcontrib><creatorcontrib>Rizos, Dimitrios</creatorcontrib><creatorcontrib>Malamitsi-Puchner, Ariadne</creatorcontrib><creatorcontrib>Giannaki, Galini</creatorcontrib><creatorcontrib>Phocas, Iphigenia</creatorcontrib><creatorcontrib>Creatsas, George</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sarandakou, Angeliki</au><au>Protonotariou, Efthimia</au><au>Rizos, Dimitrios</au><au>Malamitsi-Puchner, Ariadne</au><au>Giannaki, Galini</au><au>Phocas, Iphigenia</au><au>Creatsas, George</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SERUM LEPTIN CONCENTRATIONS DURING THE PERINATAL PERIOD</atitle><jtitle>American journal of perinatology</jtitle><addtitle>Amer J Perinatol</addtitle><date>2000</date><risdate>2000</risdate><volume>17</volume><issue>6</issue><spage>325</spage><epage>328</epage><pages>325-328</pages><issn>0735-1631</issn><eissn>1098-8785</eissn><coden>AJPEEK</coden><abstract>ABSTRACT
We aimed to study maternal and infant serum leptin concentrations during the perinatal period and their relationship to the body weight of mothers and newborns. Serum leptin values were measured by enzyme-linked immunoadsorbent assay (ELISA) (R&D systems) in 26 healthy, term neonates during the first (N1) and fifth (N5) day after birth and were compared with serum leptin values in maternal blood (MS), amniotic fluid (AF), and umbilical cord (UC) at delivery. Twenty-five healthy, nonpregnant women, age and body weight-matched to the mothers, were used as controls (C). Infant serum leptin concentrations declined significantly after birth from UC to the N5 samples (P < 0.003). MS leptin values were significantly higher than UC, N1, N5, and C values (P < 0.001), while AF values were significantly lower than in controls (P < 0.001). UC, but not MS leptin values correlated significantly with the birth weight of infants (R = 0.6; P < 0.03). The elevated values of leptin in maternal serum and the regressing pattern of infant leptin values after birth suggest an additional, probably placental source of this protein during pregnancy, possibly contributing to the regulation of fetal body weight.</abstract><cop>New York, NY</cop><pub>Thieme</pub><pmid>11144316</pmid><doi>10.1055/s-2000-13438</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0735-1631 |
| ispartof | American journal of perinatology, 2000, Vol.17 (6), p.325-328 |
| issn | 0735-1631 1098-8785 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72514740 |
| source | MEDLINE; Thieme Connect Journals |
| subjects | Adult Amniotic Fluid - chemistry Biological and medical sciences Enzyme-Linked Immunosorbent Assay Female Fetal Blood - chemistry Gynecology. Andrology. Obstetrics Humans Infant, Newborn - blood Leptin - blood Management. Prenatal diagnosis Medical sciences Perinatal Care Pregnancy - blood Pregnancy. Fetus. Placenta Reference Values Sensitivity and Specificity Statistics, Nonparametric |
| title | SERUM LEPTIN CONCENTRATIONS DURING THE PERINATAL PERIOD |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T00%3A34%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=SERUM%20LEPTIN%20CONCENTRATIONS%20DURING%20THE%20PERINATAL%20PERIOD&rft.jtitle=American%20journal%20of%20perinatology&rft.au=Sarandakou,%20Angeliki&rft.date=2000&rft.volume=17&rft.issue=6&rft.spage=325&rft.epage=328&rft.pages=325-328&rft.issn=0735-1631&rft.eissn=1098-8785&rft.coden=AJPEEK&rft_id=info:doi/10.1055/s-2000-13438&rft_dat=%3Cproquest_cross%3E72514740%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=72514740&rft_id=info:pmid/11144316&rfr_iscdi=true |