2,4,5-Trisubstituted imidazoles: novel nontoxic modulators of P-glycoprotein mediated multidrug resistance. Part 2

Solution-phase combinatorial chemistry was applied to the optimization and development of clinical candidate OC144-093 ( 22), a novel and nontoxic modulator of P-glycoprotein mediated multidrug resistance.

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Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2000-12, Vol.10 (23), p.2603-2605
Hauptverfasser:	Zhang, Chengzhi, Sarshar, Sepehr, Moran, Edmund J., Krane, Sonja, Rodarte, Jennifer C., Benbatoul, Khalid D., Dixon, Ross, Mjalli, Adnan M.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents ATP Binding Cassette Transporter, Subfamily B, Member 1 - drug effects Biological and medical sciences Combinatorial Chemistry Techniques Drug Resistance, Multiple General aspects Half-Life Humans Imidazoles - chemistry Imidazoles - pharmacokinetics Imidazoles - pharmacology Male Medical sciences Molecular Structure Pharmacology. Drug treatments Reference Values
Online-Zugang:	Volltext
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