Cephalosporin Podand Derivatives
In recent years the design and preparation of dendrimers and another multivalent molecules have emerged intensively studied subjects in organic synthesis. Biologically important substances, such as carbohydrates, amino acids often serve as the functional groups of these types of oligomers. In many c...
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| Veröffentlicht in: | Journal of antibiotics 2000/10/25, Vol.53(10), pp.1207-1211 |
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| container_issue | 10 |
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| container_title | Journal of antibiotics |
| container_volume | 53 |
| creator | KOVÁCS-KULYASSA, ÁRPÁD HERCZEGH, PÁL SZTARICSKAI, FERENC J. SZABÓ, PÁL |
| description | In recent years the design and preparation of dendrimers and another multivalent molecules have emerged intensively studied subjects in organic synthesis. Biologically important substances, such as carbohydrates, amino acids often serve as the functional groups of these types of oligomers. In many cases, related multivalent compounds possess remarkable biological effects. As an example, the so-called cluster effect in the case of the carbohydrate-containing substances is manifested in the enhanced affinity of the dendrimers towards another biomolecules due to weak, non-bonding interactions. In the field of antibiotics, covalent oligomers or polymers have only been synthesized from vancomycin, and the complex-forming, and antibacterial properties of the derivatives obtained were found to be better than that of the parent, monomeric antibiotic. |
| doi_str_mv | 10.7164/antibiotics.53.1207 |
| format | Article |
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Biologically important substances, such as carbohydrates, amino acids often serve as the functional groups of these types of oligomers. In many cases, related multivalent compounds possess remarkable biological effects. As an example, the so-called cluster effect in the case of the carbohydrate-containing substances is manifested in the enhanced affinity of the dendrimers towards another biomolecules due to weak, non-bonding interactions. In the field of antibiotics, covalent oligomers or polymers have only been synthesized from vancomycin, and the complex-forming, and antibacterial properties of the derivatives obtained were found to be better than that of the parent, monomeric antibiotic.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.53.1207</identifier><identifier>PMID: 11132968</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Antibacterial agents ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacteria - drug effects ; Biological and medical sciences ; Cephalosporins - chemical synthesis ; Cephalosporins - chemistry ; Cephalosporins - pharmacology ; Medical sciences ; Microbial Sensitivity Tests - methods ; Pharmacology. 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Antibiot.</addtitle><description>In recent years the design and preparation of dendrimers and another multivalent molecules have emerged intensively studied subjects in organic synthesis. Biologically important substances, such as carbohydrates, amino acids often serve as the functional groups of these types of oligomers. In many cases, related multivalent compounds possess remarkable biological effects. As an example, the so-called cluster effect in the case of the carbohydrate-containing substances is manifested in the enhanced affinity of the dendrimers towards another biomolecules due to weak, non-bonding interactions. In the field of antibiotics, covalent oligomers or polymers have only been synthesized from vancomycin, and the complex-forming, and antibacterial properties of the derivatives obtained were found to be better than that of the parent, monomeric antibiotic.</description><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacteria - drug effects</subject><subject>Biological and medical sciences</subject><subject>Cephalosporins - chemical synthesis</subject><subject>Cephalosporins - chemistry</subject><subject>Cephalosporins - pharmacology</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests - methods</subject><subject>Pharmacology. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Bacteria - drug effects</topic><topic>Biological and medical sciences</topic><topic>Cephalosporins - chemical synthesis</topic><topic>Cephalosporins - chemistry</topic><topic>Cephalosporins - pharmacology</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests - methods</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KOVÁCS-KULYASSA, ÁRPÁD</creatorcontrib><creatorcontrib>HERCZEGH, PÁL</creatorcontrib><creatorcontrib>SZTARICSKAI, FERENC J.</creatorcontrib><creatorcontrib>SZABÓ, PÁL</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KOVÁCS-KULYASSA, ÁRPÁD</au><au>HERCZEGH, PÁL</au><au>SZTARICSKAI, FERENC J.</au><au>SZABÓ, PÁL</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cephalosporin Podand Derivatives</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>2000-10-01</date><risdate>2000</risdate><volume>53</volume><issue>10</issue><spage>1207</spage><epage>1211</epage><pages>1207-1211</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>In recent years the design and preparation of dendrimers and another multivalent molecules have emerged intensively studied subjects in organic synthesis. Biologically important substances, such as carbohydrates, amino acids often serve as the functional groups of these types of oligomers. In many cases, related multivalent compounds possess remarkable biological effects. As an example, the so-called cluster effect in the case of the carbohydrate-containing substances is manifested in the enhanced affinity of the dendrimers towards another biomolecules due to weak, non-bonding interactions. 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| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 2000/10/25, Vol.53(10), pp.1207-1211 |
| issn | 0021-8820 1881-1469 |
| language | eng |
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| source | J-STAGE Free; MEDLINE |
| subjects | Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria - drug effects Biological and medical sciences Cephalosporins - chemical synthesis Cephalosporins - chemistry Cephalosporins - pharmacology Medical sciences Microbial Sensitivity Tests - methods Pharmacology. Drug treatments |
| title | Cephalosporin Podand Derivatives |
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