Total Synthesis of the Antitumor Antibiotic (±)-Fredericamycin A by a Linear Approach

A linear approach to the total synthesis of racemic fredericamycin A (1) through the oxidative intramolecular [4+2] cycloaddition of a (phenylthio)acetylene–cobalt complex is described, which is applicable for the asymmetric total synthesis of naturally occuring 1. The highlight of this work is the...

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Veröffentlicht in:	Chemistry : a European journal 2000-11, Vol.6 (21), p.3897-3905
Hauptverfasser:	Kita, Yasuyuki, Iio, Kiyosei, Kawaguchi, Ken-ichi, Fukuda, Nobuhisa, Takeda, Yoshifumi, Ueno, Hiroshi, Okunaka, Ryuichi, Higuchi, Kazuhiro, Tsujino, Toshiaki, Fujioka, Hiromichi, Akai, Shuji
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antineoplastic - chemical synthesis antitumor agents Cyclization cycloadditions fredericamycin A Isoquinolines - chemical synthesis Oxidation-Reduction Pummerer-type reactions Spiro Compounds - chemical synthesis Stereoisomerism total synthesis
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