Effects of electrical stimulation leg training during the acute phase of spinal cord injury: a pilot study
Four individuals with a spinal cord injury underwent 16 weeks of isometric electrical stimulation training to both legs for 60 min, five times per week during the first 5 months after injury, while two SCI individuals remained untrained. A baseline biopsy sample of the vastus lateralis muscle was ob...
Gespeichert in:
| Veröffentlicht in: | European journal of applied physiology 2000-11, Vol.83 (4 -5), p.409-415 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 415 |
|---|---|
| container_issue | 4 -5 |
| container_start_page | 409 |
| container_title | European journal of applied physiology |
| container_volume | 83 |
| creator | Crameri, R M Weston, A R Rutkowski, S Middleton, J W Davis, G M Sutton, J R |
| description | Four individuals with a spinal cord injury underwent 16 weeks of isometric electrical stimulation training to both legs for 60 min, five times per week during the first 5 months after injury, while two SCI individuals remained untrained. A baseline biopsy sample of the vastus lateralis muscle was obtained within 1 month of injury, and another biopsy sample was taken after a further 16 weeks. The untrained, paralyzed skeletal muscle displayed a reduction in (1) type I fibers (from 50% to 9%), (2) myosin heavy chain (MHC) I (from 27% to 6%), and (3) fiber cross-sectional area of type I, type IIA and type IIX fibers (-62%, -68%, and -55%, respectively) when compared to the baseline sample of muscle taken within 1 month of injury. In contrast, the trained group showed smaller alterations in type I fibers (from 49% to 40%) and MHC I composition (from 39% to 25%), while fiber cross-sectional area was similar to baseline levels for type I, type IIA and type IIX fibers (-3%, -8%, and -4%, respectively). In conclusion, electrical stimulation training can largely prevent the adverse effects of a spinal cord injury upon paralyzed human skeletal muscle if applied soon after the injury. |
| doi_str_mv | 10.1007/s004210000263 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72511225</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>72511225</sourcerecordid><originalsourceid>FETCH-LOGICAL-c349t-86f1fd5d7eafec8b288adca586cb5b352b2b87c7e8c1d0933db71cda3b1dd8d53</originalsourceid><addsrcrecordid>eNp9kTtPwzAUhS0EoqUwsiKLAbEEfO08HDZUlYdUiQXmyLGd1lWaBD-G_nsctQLBwHTO8J2je3UQugRyB4QU946QlEZHCM3ZEZpCysokZ7Q4_vZQTtCZc5vIcAr8FE0AgPGMsynaLJpGS-9w32DdRmeNFC123mxDK7zpO9zqFfZWmM50K6yCHcWvNRYyeI2HtXB6TLvBdDEpe6uw6TbB7h6wwINpex_rgtqdo5NGtE5fHHSGPp4W7_OXZPn2_Dp_XCaSpaVPeN5AozJVaBEv4zXlXCgpMp7LOqtZRmta80IWmktQpGRM1QVIJVgNSnGVsRm62fcOtv8M2vlqa5zUbSs63QdXFTQDoHQEb_8FIac0J7SkENHrP-imDzb-6ypesoJBltIIJXtI2t45q5tqsGYr7K4CUo1jVb_GivzVoTTUW61-6MM67AuDP4_g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>893731542</pqid></control><display><type>article</type><title>Effects of electrical stimulation leg training during the acute phase of spinal cord injury: a pilot study</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Crameri, R M ; Weston, A R ; Rutkowski, S ; Middleton, J W ; Davis, G M ; Sutton, J R</creator><creatorcontrib>Crameri, R M ; Weston, A R ; Rutkowski, S ; Middleton, J W ; Davis, G M ; Sutton, J R</creatorcontrib><description>Four individuals with a spinal cord injury underwent 16 weeks of isometric electrical stimulation training to both legs for 60 min, five times per week during the first 5 months after injury, while two SCI individuals remained untrained. A baseline biopsy sample of the vastus lateralis muscle was obtained within 1 month of injury, and another biopsy sample was taken after a further 16 weeks. The untrained, paralyzed skeletal muscle displayed a reduction in (1) type I fibers (from 50% to 9%), (2) myosin heavy chain (MHC) I (from 27% to 6%), and (3) fiber cross-sectional area of type I, type IIA and type IIX fibers (-62%, -68%, and -55%, respectively) when compared to the baseline sample of muscle taken within 1 month of injury. In contrast, the trained group showed smaller alterations in type I fibers (from 49% to 40%) and MHC I composition (from 39% to 25%), while fiber cross-sectional area was similar to baseline levels for type I, type IIA and type IIX fibers (-3%, -8%, and -4%, respectively). In conclusion, electrical stimulation training can largely prevent the adverse effects of a spinal cord injury upon paralyzed human skeletal muscle if applied soon after the injury.</description><identifier>ISSN: 1439-6319</identifier><identifier>EISSN: 1439-6327</identifier><identifier>DOI: 10.1007/s004210000263</identifier><identifier>PMID: 11138583</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Adolescent ; Adult ; Biopsy ; Electric Stimulation Therapy ; Female ; Health sciences ; Humans ; Leg ; Male ; Middle Aged ; Morphology ; Muscle Fibers, Skeletal - chemistry ; Muscle, Skeletal - metabolism ; Muscle, Skeletal - pathology ; Muscular Atrophy - pathology ; Musculoskeletal system ; Myosin Heavy Chains - chemistry ; Nitrogen ; Paralysis ; Paraplegia - metabolism ; Paraplegia - pathology ; Paraplegia - therapy ; Pilot Projects ; Rehabilitation ; Spinal cord injuries ; Spinal Cord Injuries - metabolism ; Spinal Cord Injuries - pathology ; Spinal Cord Injuries - therapy</subject><ispartof>European journal of applied physiology, 2000-11, Vol.83 (4 -5), p.409-415</ispartof><rights>Springer-Verlag Berlin Heidelberg 2000</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c349t-86f1fd5d7eafec8b288adca586cb5b352b2b87c7e8c1d0933db71cda3b1dd8d53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11138583$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Crameri, R M</creatorcontrib><creatorcontrib>Weston, A R</creatorcontrib><creatorcontrib>Rutkowski, S</creatorcontrib><creatorcontrib>Middleton, J W</creatorcontrib><creatorcontrib>Davis, G M</creatorcontrib><creatorcontrib>Sutton, J R</creatorcontrib><title>Effects of electrical stimulation leg training during the acute phase of spinal cord injury: a pilot study</title><title>European journal of applied physiology</title><addtitle>Eur J Appl Physiol</addtitle><description>Four individuals with a spinal cord injury underwent 16 weeks of isometric electrical stimulation training to both legs for 60 min, five times per week during the first 5 months after injury, while two SCI individuals remained untrained. A baseline biopsy sample of the vastus lateralis muscle was obtained within 1 month of injury, and another biopsy sample was taken after a further 16 weeks. The untrained, paralyzed skeletal muscle displayed a reduction in (1) type I fibers (from 50% to 9%), (2) myosin heavy chain (MHC) I (from 27% to 6%), and (3) fiber cross-sectional area of type I, type IIA and type IIX fibers (-62%, -68%, and -55%, respectively) when compared to the baseline sample of muscle taken within 1 month of injury. In contrast, the trained group showed smaller alterations in type I fibers (from 49% to 40%) and MHC I composition (from 39% to 25%), while fiber cross-sectional area was similar to baseline levels for type I, type IIA and type IIX fibers (-3%, -8%, and -4%, respectively). In conclusion, electrical stimulation training can largely prevent the adverse effects of a spinal cord injury upon paralyzed human skeletal muscle if applied soon after the injury.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Biopsy</subject><subject>Electric Stimulation Therapy</subject><subject>Female</subject><subject>Health sciences</subject><subject>Humans</subject><subject>Leg</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Morphology</subject><subject>Muscle Fibers, Skeletal - chemistry</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscle, Skeletal - pathology</subject><subject>Muscular Atrophy - pathology</subject><subject>Musculoskeletal system</subject><subject>Myosin Heavy Chains - chemistry</subject><subject>Nitrogen</subject><subject>Paralysis</subject><subject>Paraplegia - metabolism</subject><subject>Paraplegia - pathology</subject><subject>Paraplegia - therapy</subject><subject>Pilot Projects</subject><subject>Rehabilitation</subject><subject>Spinal cord injuries</subject><subject>Spinal Cord Injuries - metabolism</subject><subject>Spinal Cord Injuries - pathology</subject><subject>Spinal Cord Injuries - therapy</subject><issn>1439-6319</issn><issn>1439-6327</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kTtPwzAUhS0EoqUwsiKLAbEEfO08HDZUlYdUiQXmyLGd1lWaBD-G_nsctQLBwHTO8J2je3UQugRyB4QU946QlEZHCM3ZEZpCysokZ7Q4_vZQTtCZc5vIcAr8FE0AgPGMsynaLJpGS-9w32DdRmeNFC123mxDK7zpO9zqFfZWmM50K6yCHcWvNRYyeI2HtXB6TLvBdDEpe6uw6TbB7h6wwINpex_rgtqdo5NGtE5fHHSGPp4W7_OXZPn2_Dp_XCaSpaVPeN5AozJVaBEv4zXlXCgpMp7LOqtZRmta80IWmktQpGRM1QVIJVgNSnGVsRm62fcOtv8M2vlqa5zUbSs63QdXFTQDoHQEb_8FIac0J7SkENHrP-imDzb-6ypesoJBltIIJXtI2t45q5tqsGYr7K4CUo1jVb_GivzVoTTUW61-6MM67AuDP4_g</recordid><startdate>20001101</startdate><enddate>20001101</enddate><creator>Crameri, R M</creator><creator>Weston, A R</creator><creator>Rutkowski, S</creator><creator>Middleton, J W</creator><creator>Davis, G M</creator><creator>Sutton, J R</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>20001101</creationdate><title>Effects of electrical stimulation leg training during the acute phase of spinal cord injury: a pilot study</title><author>Crameri, R M ; Weston, A R ; Rutkowski, S ; Middleton, J W ; Davis, G M ; Sutton, J R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c349t-86f1fd5d7eafec8b288adca586cb5b352b2b87c7e8c1d0933db71cda3b1dd8d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Biopsy</topic><topic>Electric Stimulation Therapy</topic><topic>Female</topic><topic>Health sciences</topic><topic>Humans</topic><topic>Leg</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Morphology</topic><topic>Muscle Fibers, Skeletal - chemistry</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscle, Skeletal - pathology</topic><topic>Muscular Atrophy - pathology</topic><topic>Musculoskeletal system</topic><topic>Myosin Heavy Chains - chemistry</topic><topic>Nitrogen</topic><topic>Paralysis</topic><topic>Paraplegia - metabolism</topic><topic>Paraplegia - pathology</topic><topic>Paraplegia - therapy</topic><topic>Pilot Projects</topic><topic>Rehabilitation</topic><topic>Spinal cord injuries</topic><topic>Spinal Cord Injuries - metabolism</topic><topic>Spinal Cord Injuries - pathology</topic><topic>Spinal Cord Injuries - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Crameri, R M</creatorcontrib><creatorcontrib>Weston, A R</creatorcontrib><creatorcontrib>Rutkowski, S</creatorcontrib><creatorcontrib>Middleton, J W</creatorcontrib><creatorcontrib>Davis, G M</creatorcontrib><creatorcontrib>Sutton, J R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of applied physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Crameri, R M</au><au>Weston, A R</au><au>Rutkowski, S</au><au>Middleton, J W</au><au>Davis, G M</au><au>Sutton, J R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of electrical stimulation leg training during the acute phase of spinal cord injury: a pilot study</atitle><jtitle>European journal of applied physiology</jtitle><addtitle>Eur J Appl Physiol</addtitle><date>2000-11-01</date><risdate>2000</risdate><volume>83</volume><issue>4 -5</issue><spage>409</spage><epage>415</epage><pages>409-415</pages><issn>1439-6319</issn><eissn>1439-6327</eissn><abstract>Four individuals with a spinal cord injury underwent 16 weeks of isometric electrical stimulation training to both legs for 60 min, five times per week during the first 5 months after injury, while two SCI individuals remained untrained. A baseline biopsy sample of the vastus lateralis muscle was obtained within 1 month of injury, and another biopsy sample was taken after a further 16 weeks. The untrained, paralyzed skeletal muscle displayed a reduction in (1) type I fibers (from 50% to 9%), (2) myosin heavy chain (MHC) I (from 27% to 6%), and (3) fiber cross-sectional area of type I, type IIA and type IIX fibers (-62%, -68%, and -55%, respectively) when compared to the baseline sample of muscle taken within 1 month of injury. In contrast, the trained group showed smaller alterations in type I fibers (from 49% to 40%) and MHC I composition (from 39% to 25%), while fiber cross-sectional area was similar to baseline levels for type I, type IIA and type IIX fibers (-3%, -8%, and -4%, respectively). In conclusion, electrical stimulation training can largely prevent the adverse effects of a spinal cord injury upon paralyzed human skeletal muscle if applied soon after the injury.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>11138583</pmid><doi>10.1007/s004210000263</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1439-6319 |
| ispartof | European journal of applied physiology, 2000-11, Vol.83 (4 -5), p.409-415 |
| issn | 1439-6319 1439-6327 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72511225 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adolescent Adult Biopsy Electric Stimulation Therapy Female Health sciences Humans Leg Male Middle Aged Morphology Muscle Fibers, Skeletal - chemistry Muscle, Skeletal - metabolism Muscle, Skeletal - pathology Muscular Atrophy - pathology Musculoskeletal system Myosin Heavy Chains - chemistry Nitrogen Paralysis Paraplegia - metabolism Paraplegia - pathology Paraplegia - therapy Pilot Projects Rehabilitation Spinal cord injuries Spinal Cord Injuries - metabolism Spinal Cord Injuries - pathology Spinal Cord Injuries - therapy |
| title | Effects of electrical stimulation leg training during the acute phase of spinal cord injury: a pilot study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-11T23%3A30%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20electrical%20stimulation%20leg%20training%20during%20the%20acute%20phase%20of%20spinal%20cord%20injury:%20a%20pilot%20study&rft.jtitle=European%20journal%20of%20applied%20physiology&rft.au=Crameri,%20R%20M&rft.date=2000-11-01&rft.volume=83&rft.issue=4%20-5&rft.spage=409&rft.epage=415&rft.pages=409-415&rft.issn=1439-6319&rft.eissn=1439-6327&rft_id=info:doi/10.1007/s004210000263&rft_dat=%3Cproquest_cross%3E72511225%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=893731542&rft_id=info:pmid/11138583&rfr_iscdi=true |