Effective artificial proteases synthesized by covering silica gel with aldehyde and various other organic groups

Organic artificial proteases with broad substrate specificity were synthesized by covering the surface of silica gel with aldehyde and the functional groups present in amino acids. The artificial proteases hydrolyzed ovalbumin, albumin, hemoglobin, γ-globulin with half-lives as short as 50 min at 25 °C or 7 min at 50 °C. Organic artificial proteases with broad substrate specificity were synthesized by covering silica gel with aldehyde and functional groups present in amino acids.