Astrocytes increase the functional expression of P-glycoprotein in an in vitro model of the blood-brain barrier

To investigate the influence of astrocytes on P-glycoprotein (Pgp) expression and intracellular accumulation of Pgp substrates, separate from their net transcellular transport across the blood-brain barrier (BBB). An in vitro BBB model was used, comprising of brain capillary endothelial cells (BCEC)...

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Veröffentlicht in:	Pharmaceutical research 2000-10, Vol.17 (10), p.1198-1205
Hauptverfasser:	GAILLARD, Pieter Jaap, VAN DER SANDT, Inez Cornelia, VOORWINDEN, Levina Helena, VU, Dung, NIELSEN, Jette Lyngholm, DE BOER, Albertus Gerrit, BREIMER, Douwe Durk
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Agents, Phytogenic - pharmacokinetics Astrocytes - cytology Astrocytes - physiology ATP Binding Cassette Transporter, Subfamily B, Member 1 - biosynthesis ATP Binding Cassette Transporter, Subfamily B, Member 1 - genetics ATP Binding Cassette Transporter, Subfamily B, Member 1 - physiology Biological and medical sciences Blood-Brain Barrier - physiology Brain - blood supply Caco-2 Cells - metabolism Capillaries - cytology Capillaries - metabolism Cattle Cell physiology Coculture Techniques Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Fluorescent Dyes - pharmacokinetics Fundamental and applied biological sciences. Psychology General aspects Humans Medical sciences Membrane and intracellular transports Molecular and cellular biology Pharmacology. Drug treatments Rhodamine 123 - pharmacokinetics Transfection Vinblastine - pharmacokinetics
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