Age, sex, haemoglobin level, and white cell count at diagnosis are important prognostic factors in children with acute lymphoblastic leukemia treated with BFM-type protocol
The presenting features and treatment outcome for 575 Malaysian children (≤12 years of age) with newly diagnosed acute lymphoblastic leukemia (ALL), admitted to the University Hospital, Kuala Lumpur, Malaysia between 1 January 1980 and 30 May 1995 were evaluated to determine their prognostic signifi...
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| Veröffentlicht in: | Journal of tropical pediatrics (1980) 2000-12, Vol.46 (6), p.338-343 |
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| creator | Ng, SM Lin, HP Ariffin, WA Zainab, AK Lam, SK Chan, LL |
| description | The presenting features and treatment outcome for 575 Malaysian children (≤12 years of age) with newly diagnosed acute lymphoblastic leukemia (ALL), admitted to the University Hospital, Kuala Lumpur, Malaysia between 1 January 1980 and 30 May 1995 were evaluated to determine their prognostic significance. Two-year overall survival was achieved in 67 per cent of all patients and 55 per cent of patients were relapse-free at 2 years. All except 10 patients, with identified French-American-British L3 morphology were treated with the modified Berlin-Frankfurt-Munster 78 treatment protocol. Univariate analyses of failure rate conferred age, sex, white cell count and hemoglobin level as potentially significant prognostic factors. All four presenting features retained their prognostic strength in a multivariate analysis. Race, platelet count, morphological subtype, liver/spleen size, lymphadenopathy, central nervous system and mediastinal mass involvement did not show any significant effect on treatment outcome. The 2-year survival rate was significantly different with regard to age, white cell count and hemoglobin level. However, sex was not significantly related to overall survival. These prognostic factors may have implications on future stratification of risk-adjusted initial treatment in the management of childhood ALL. Our analysis of Malaysian children is similar to what could be predicted based on previous studies in other populations. |
| doi_str_mv | 10.1093/tropej/46.6.338 |
| format | Article |
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Two-year overall survival was achieved in 67 per cent of all patients and 55 per cent of patients were relapse-free at 2 years. All except 10 patients, with identified French-American-British L3 morphology were treated with the modified Berlin-Frankfurt-Munster 78 treatment protocol. Univariate analyses of failure rate conferred age, sex, white cell count and hemoglobin level as potentially significant prognostic factors. All four presenting features retained their prognostic strength in a multivariate analysis. Race, platelet count, morphological subtype, liver/spleen size, lymphadenopathy, central nervous system and mediastinal mass involvement did not show any significant effect on treatment outcome. The 2-year survival rate was significantly different with regard to age, white cell count and hemoglobin level. However, sex was not significantly related to overall survival. These prognostic factors may have implications on future stratification of risk-adjusted initial treatment in the management of childhood ALL. Our analysis of Malaysian children is similar to what could be predicted based on previous studies in other populations.</description><identifier>ISSN: 0142-6338</identifier><identifier>EISSN: 1465-3664</identifier><identifier>DOI: 10.1093/tropej/46.6.338</identifier><identifier>PMID: 11191144</identifier><identifier>CODEN: JTRPAO</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Age Factors ; Analysis. Health state ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Biological and medical sciences ; Child ; Child, Preschool ; Clinical Protocols ; Epidemiology ; Female ; General aspects ; Hematologic and hematopoietic diseases ; Hemoglobins - analysis ; Humans ; Infant ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Leukocyte Count ; Male ; Medical sciences ; Multivariate Analysis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy ; Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality ; Predictive Value of Tests ; Prognosis ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Retrospective Studies ; Risk Factors ; Sex Factors ; Survival Rate ; Treatment Outcome ; Tropical medicine</subject><ispartof>Journal of tropical pediatrics (1980), 2000-12, Vol.46 (6), p.338-343</ispartof><rights>2001 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Dec 2000</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c458t-63d689d91b34ff591600fc834ce548706d100f00649a272f3b40e811e3b5051d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=827749$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11191144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ng, SM</creatorcontrib><creatorcontrib>Lin, HP</creatorcontrib><creatorcontrib>Ariffin, WA</creatorcontrib><creatorcontrib>Zainab, AK</creatorcontrib><creatorcontrib>Lam, SK</creatorcontrib><creatorcontrib>Chan, LL</creatorcontrib><title>Age, sex, haemoglobin level, and white cell count at diagnosis are important prognostic factors in children with acute lymphoblastic leukemia treated with BFM-type protocol</title><title>Journal of tropical pediatrics (1980)</title><addtitle>J Trop Pediatr</addtitle><description>The presenting features and treatment outcome for 575 Malaysian children (≤12 years of age) with newly diagnosed acute lymphoblastic leukemia (ALL), admitted to the University Hospital, Kuala Lumpur, Malaysia between 1 January 1980 and 30 May 1995 were evaluated to determine their prognostic significance. Two-year overall survival was achieved in 67 per cent of all patients and 55 per cent of patients were relapse-free at 2 years. All except 10 patients, with identified French-American-British L3 morphology were treated with the modified Berlin-Frankfurt-Munster 78 treatment protocol. Univariate analyses of failure rate conferred age, sex, white cell count and hemoglobin level as potentially significant prognostic factors. All four presenting features retained their prognostic strength in a multivariate analysis. Race, platelet count, morphological subtype, liver/spleen size, lymphadenopathy, central nervous system and mediastinal mass involvement did not show any significant effect on treatment outcome. The 2-year survival rate was significantly different with regard to age, white cell count and hemoglobin level. However, sex was not significantly related to overall survival. These prognostic factors may have implications on future stratification of risk-adjusted initial treatment in the management of childhood ALL. Our analysis of Malaysian children is similar to what could be predicted based on previous studies in other populations.</description><subject>Age Factors</subject><subject>Analysis. Health state</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Clinical Protocols</subject><subject>Epidemiology</subject><subject>Female</subject><subject>General aspects</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hemoglobins - analysis</subject><subject>Humans</subject><subject>Infant</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy</subject><subject>Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Survival Rate</subject><subject>Treatment Outcome</subject><subject>Tropical medicine</subject><issn>0142-6338</issn><issn>1465-3664</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0UFv0zAUB_AIgVgZnLkhCyROTWvHjuMcx8QYUieEBCriYjnOS-vOiYPtsPU78SFxaTUkLpwsPf_8f3p-WfaS4AXBNV1G70bYLRlf8AWl4lE2I4yXOeWcPc5mmLAi56l-lj0LYYcxLgRjT7MzQkhNCGOz7NfFBuYowP0cbRX0bmNdYwZk4SfYOVJDi-62JgLSYC3SbhoiUhG1Rm0GF0xAygMy_eh8VOlq9O5Qj0ajTunofEApTG-NbT0M6M7ELVJ6Snl2349b11j1B1uYbqE3CkUPKkJ7lO-ubvK4H-EQG5129nn2pFM2wIvTeZ59vXr_5fI6X3368PHyYpVrVoqYJm65qNuaNJR1XVkTjnGnBWUaSiYqzFuSChhzVquiKjraMAyCEKBNiUvS0vPs7TE3Nf4xQYiyN-HwA2oANwVZFSWuCRP_hQUuRZ1aJvj6H7hzkx_SELIoGGWiYCSh5RFp70Lw0MnRm175vSRYHtYtj-uWjEsu01rTi1en2Knpof3rT_tN4M0JqKCV7bwatAkPThRVxeqk8qMyIcL9w63yt5JXtCrl9bfvcn1Trtbk81oS-htUDsTO</recordid><startdate>20001201</startdate><enddate>20001201</enddate><creator>Ng, SM</creator><creator>Lin, HP</creator><creator>Ariffin, WA</creator><creator>Zainab, AK</creator><creator>Lam, SK</creator><creator>Chan, LL</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7TM</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>20001201</creationdate><title>Age, sex, haemoglobin level, and white cell count at diagnosis are important prognostic factors in children with acute lymphoblastic leukemia treated with BFM-type protocol</title><author>Ng, SM ; Lin, HP ; Ariffin, WA ; Zainab, AK ; Lam, SK ; Chan, LL</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c458t-63d689d91b34ff591600fc834ce548706d100f00649a272f3b40e811e3b5051d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Age Factors</topic><topic>Analysis. Health state</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Clinical Protocols</topic><topic>Epidemiology</topic><topic>Female</topic><topic>General aspects</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hemoglobins - analysis</topic><topic>Humans</topic><topic>Infant</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy</topic><topic>Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Survival Rate</topic><topic>Treatment Outcome</topic><topic>Tropical medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ng, SM</creatorcontrib><creatorcontrib>Lin, HP</creatorcontrib><creatorcontrib>Ariffin, WA</creatorcontrib><creatorcontrib>Zainab, AK</creatorcontrib><creatorcontrib>Lam, SK</creatorcontrib><creatorcontrib>Chan, LL</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of tropical pediatrics (1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ng, SM</au><au>Lin, HP</au><au>Ariffin, WA</au><au>Zainab, AK</au><au>Lam, SK</au><au>Chan, LL</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Age, sex, haemoglobin level, and white cell count at diagnosis are important prognostic factors in children with acute lymphoblastic leukemia treated with BFM-type protocol</atitle><jtitle>Journal of tropical pediatrics (1980)</jtitle><addtitle>J Trop Pediatr</addtitle><date>2000-12-01</date><risdate>2000</risdate><volume>46</volume><issue>6</issue><spage>338</spage><epage>343</epage><pages>338-343</pages><issn>0142-6338</issn><eissn>1465-3664</eissn><coden>JTRPAO</coden><abstract>The presenting features and treatment outcome for 575 Malaysian children (≤12 years of age) with newly diagnosed acute lymphoblastic leukemia (ALL), admitted to the University Hospital, Kuala Lumpur, Malaysia between 1 January 1980 and 30 May 1995 were evaluated to determine their prognostic significance. Two-year overall survival was achieved in 67 per cent of all patients and 55 per cent of patients were relapse-free at 2 years. All except 10 patients, with identified French-American-British L3 morphology were treated with the modified Berlin-Frankfurt-Munster 78 treatment protocol. Univariate analyses of failure rate conferred age, sex, white cell count and hemoglobin level as potentially significant prognostic factors. All four presenting features retained their prognostic strength in a multivariate analysis. Race, platelet count, morphological subtype, liver/spleen size, lymphadenopathy, central nervous system and mediastinal mass involvement did not show any significant effect on treatment outcome. The 2-year survival rate was significantly different with regard to age, white cell count and hemoglobin level. However, sex was not significantly related to overall survival. These prognostic factors may have implications on future stratification of risk-adjusted initial treatment in the management of childhood ALL. Our analysis of Malaysian children is similar to what could be predicted based on previous studies in other populations.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>11191144</pmid><doi>10.1093/tropej/46.6.338</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0142-6338 |
| ispartof | Journal of tropical pediatrics (1980), 2000-12, Vol.46 (6), p.338-343 |
| issn | 0142-6338 1465-3664 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE |
| subjects | Age Factors Analysis. Health state Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Child Child, Preschool Clinical Protocols Epidemiology Female General aspects Hematologic and hematopoietic diseases Hemoglobins - analysis Humans Infant Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Leukocyte Count Male Medical sciences Multivariate Analysis Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood Precursor Cell Lymphoblastic Leukemia-Lymphoma - diagnosis Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality Predictive Value of Tests Prognosis Public health. Hygiene Public health. Hygiene-occupational medicine Retrospective Studies Risk Factors Sex Factors Survival Rate Treatment Outcome Tropical medicine |
| title | Age, sex, haemoglobin level, and white cell count at diagnosis are important prognostic factors in children with acute lymphoblastic leukemia treated with BFM-type protocol |
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