Effects of PAD on conduction of action potentials within segmental and ascending branches of single muscle afferents in the cat spinal cord
In anesthetized and paralyzed cats under artificial respiration, we examined the extent to which primary afferent depolarization (PAD) might affect invasion of action potentials in intraspinal axonal and/or terminal branches of single muscle afferents. To this end, one stimulating micropipette was p...
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| Veröffentlicht in: | Experimental brain research 2000-11, Vol.135 (2), p.204-214 |
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| creator | LOMELI, Joel CASTILLO, Luis LINARES, Pablo RUDOMIN, Pablo |
| description | In anesthetized and paralyzed cats under artificial respiration, we examined the extent to which primary afferent depolarization (PAD) might affect invasion of action potentials in intraspinal axonal and/or terminal branches of single muscle afferents. To this end, one stimulating micropipette was placed at the L6 spinal level within the intermediate or motor nucleus, and another one at the L3 level, in or close to Clarke's column. Antidromically conducted responses produced in single muscle afferents by stimulation at these two spinal levels were recorded from fine lateral gastrocnemius nerve filaments. In all fibers examined, stimulation of one branch, with strengths producing action potentials, increased the intraspinal threshold of the other branch when applied at short conditioning testing stimulus intervals ( |
| doi_str_mv | 10.1007/s002210000524 |
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To this end, one stimulating micropipette was placed at the L6 spinal level within the intermediate or motor nucleus, and another one at the L3 level, in or close to Clarke's column. Antidromically conducted responses produced in single muscle afferents by stimulation at these two spinal levels were recorded from fine lateral gastrocnemius nerve filaments. In all fibers examined, stimulation of one branch, with strengths producing action potentials, increased the intraspinal threshold of the other branch when applied at short conditioning testing stimulus intervals (<1.5-2.0 ms), because of the refractoriness produced by the action potentials invading the tested branch. Similar increases in the intraspinal threshold were found in branches showing tonic PAD and also during the PAD evoked by stimulation of group I afferent fibers in muscle nerves. It is concluded that during tonic or evoked PAD, axonal branches in the dorsal columns and myelinated terminals of muscle afferents ending deep in the L6 and L3 segmental levels continue to be invaded by action potentials. These findings strengthen the view that presynaptic inhibition of muscle afferents produced by activation of GABAergic mechanisms is more likely to result from changes in the synaptic effectiveness of the afferent terminals than from conduction failure because of PAD.</description><identifier>ISSN: 0014-4819</identifier><identifier>EISSN: 1432-1106</identifier><identifier>DOI: 10.1007/s002210000524</identifier><identifier>PMID: 11131505</identifier><identifier>CODEN: EXBRAP</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Action Potentials - physiology ; Animals ; Biological and medical sciences ; Cats ; Central nervous system ; Central neurotransmission. Neuromudulation. Pathways and receptors ; Clarke's column ; Differential Threshold ; Electric Stimulation ; Electrophysiology ; Fundamental and applied biological sciences. Psychology ; Muscle, Skeletal - innervation ; Nerve Fibers - physiology ; Nervous System Physiological Phenomena ; Neural Conduction - physiology ; Neurons, Afferent - physiology ; Refractory Period, Electrophysiological ; Spinal Cord - cytology ; Spinal Cord - physiology ; Time Factors ; Vertebrates: nervous system and sense organs</subject><ispartof>Experimental brain research, 2000-11, Vol.135 (2), p.204-214</ispartof><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c348t-a11c05fadb00b19f57bb3d325530d7c510040a7bd078016b26c2e377c409ed5f3</citedby><cites>FETCH-LOGICAL-c348t-a11c05fadb00b19f57bb3d325530d7c510040a7bd078016b26c2e377c409ed5f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=859683$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11131505$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LOMELI, Joel</creatorcontrib><creatorcontrib>CASTILLO, Luis</creatorcontrib><creatorcontrib>LINARES, Pablo</creatorcontrib><creatorcontrib>RUDOMIN, Pablo</creatorcontrib><title>Effects of PAD on conduction of action potentials within segmental and ascending branches of single muscle afferents in the cat spinal cord</title><title>Experimental brain research</title><addtitle>Exp Brain Res</addtitle><description>In anesthetized and paralyzed cats under artificial respiration, we examined the extent to which primary afferent depolarization (PAD) might affect invasion of action potentials in intraspinal axonal and/or terminal branches of single muscle afferents. To this end, one stimulating micropipette was placed at the L6 spinal level within the intermediate or motor nucleus, and another one at the L3 level, in or close to Clarke's column. Antidromically conducted responses produced in single muscle afferents by stimulation at these two spinal levels were recorded from fine lateral gastrocnemius nerve filaments. In all fibers examined, stimulation of one branch, with strengths producing action potentials, increased the intraspinal threshold of the other branch when applied at short conditioning testing stimulus intervals (<1.5-2.0 ms), because of the refractoriness produced by the action potentials invading the tested branch. Similar increases in the intraspinal threshold were found in branches showing tonic PAD and also during the PAD evoked by stimulation of group I afferent fibers in muscle nerves. It is concluded that during tonic or evoked PAD, axonal branches in the dorsal columns and myelinated terminals of muscle afferents ending deep in the L6 and L3 segmental levels continue to be invaded by action potentials. These findings strengthen the view that presynaptic inhibition of muscle afferents produced by activation of GABAergic mechanisms is more likely to result from changes in the synaptic effectiveness of the afferent terminals than from conduction failure because of PAD.</description><subject>Action Potentials - physiology</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cats</subject><subject>Central nervous system</subject><subject>Central neurotransmission. Neuromudulation. Pathways and receptors</subject><subject>Clarke's column</subject><subject>Differential Threshold</subject><subject>Electric Stimulation</subject><subject>Electrophysiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Muscle, Skeletal - innervation</subject><subject>Nerve Fibers - physiology</subject><subject>Nervous System Physiological Phenomena</subject><subject>Neural Conduction - physiology</subject><subject>Neurons, Afferent - physiology</subject><subject>Refractory Period, Electrophysiological</subject><subject>Spinal Cord - cytology</subject><subject>Spinal Cord - physiology</subject><subject>Time Factors</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0014-4819</issn><issn>1432-1106</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1LxDAQhoMoun4cvUpA8FadSZpN9yh-g6AHPZc0H26kTdcmRfwN_mmz7qJ48jRvhmfeCe8QcohwigDyLAIwlhWAYOUGmWDJWYEI000yAcCyKCuc7ZDdGF-XTy5hm-wgIkcBYkI-r5yzOkXaO_p4fkn7QHUfzKiTzzI31Uot-mRD8qqN9N2nuQ802pcut1RLVTBURW2D8eGFNoMKem6_HWNutJZ2Y9S5qLxqyCOR5vE0t1SrROPCh-yh-8Hsky2XF9iDdd0jz9dXTxe3xf3Dzd3F-X2heVmlQiFqEE6ZBqDBmROyabjhTAgORmqRwyhBycaArACnDZtqZrmUuoSZNcLxPXKy8l0M_dtoY6o7n7_ftirYfoy1ZAIqZPxfEKXkHGEJFitQD32Mg3X1YvCdGj5qhHp5pvrPmTJ_tDYem86aX3p9lwwcr4EcrGrdMlMff7hKzKYV519PcZoZ</recordid><startdate>20001101</startdate><enddate>20001101</enddate><creator>LOMELI, Joel</creator><creator>CASTILLO, Luis</creator><creator>LINARES, Pablo</creator><creator>RUDOMIN, Pablo</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20001101</creationdate><title>Effects of PAD on conduction of action potentials within segmental and ascending branches of single muscle afferents in the cat spinal cord</title><author>LOMELI, Joel ; CASTILLO, Luis ; LINARES, Pablo ; RUDOMIN, Pablo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c348t-a11c05fadb00b19f57bb3d325530d7c510040a7bd078016b26c2e377c409ed5f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Action Potentials - physiology</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cats</topic><topic>Central nervous system</topic><topic>Central neurotransmission. Neuromudulation. Pathways and receptors</topic><topic>Clarke's column</topic><topic>Differential Threshold</topic><topic>Electric Stimulation</topic><topic>Electrophysiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Muscle, Skeletal - innervation</topic><topic>Nerve Fibers - physiology</topic><topic>Nervous System Physiological Phenomena</topic><topic>Neural Conduction - physiology</topic><topic>Neurons, Afferent - physiology</topic><topic>Refractory Period, Electrophysiological</topic><topic>Spinal Cord - cytology</topic><topic>Spinal Cord - physiology</topic><topic>Time Factors</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LOMELI, Joel</creatorcontrib><creatorcontrib>CASTILLO, Luis</creatorcontrib><creatorcontrib>LINARES, Pablo</creatorcontrib><creatorcontrib>RUDOMIN, Pablo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LOMELI, Joel</au><au>CASTILLO, Luis</au><au>LINARES, Pablo</au><au>RUDOMIN, Pablo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of PAD on conduction of action potentials within segmental and ascending branches of single muscle afferents in the cat spinal cord</atitle><jtitle>Experimental brain research</jtitle><addtitle>Exp Brain Res</addtitle><date>2000-11-01</date><risdate>2000</risdate><volume>135</volume><issue>2</issue><spage>204</spage><epage>214</epage><pages>204-214</pages><issn>0014-4819</issn><eissn>1432-1106</eissn><coden>EXBRAP</coden><abstract>In anesthetized and paralyzed cats under artificial respiration, we examined the extent to which primary afferent depolarization (PAD) might affect invasion of action potentials in intraspinal axonal and/or terminal branches of single muscle afferents. To this end, one stimulating micropipette was placed at the L6 spinal level within the intermediate or motor nucleus, and another one at the L3 level, in or close to Clarke's column. Antidromically conducted responses produced in single muscle afferents by stimulation at these two spinal levels were recorded from fine lateral gastrocnemius nerve filaments. In all fibers examined, stimulation of one branch, with strengths producing action potentials, increased the intraspinal threshold of the other branch when applied at short conditioning testing stimulus intervals (<1.5-2.0 ms), because of the refractoriness produced by the action potentials invading the tested branch. Similar increases in the intraspinal threshold were found in branches showing tonic PAD and also during the PAD evoked by stimulation of group I afferent fibers in muscle nerves. It is concluded that during tonic or evoked PAD, axonal branches in the dorsal columns and myelinated terminals of muscle afferents ending deep in the L6 and L3 segmental levels continue to be invaded by action potentials. These findings strengthen the view that presynaptic inhibition of muscle afferents produced by activation of GABAergic mechanisms is more likely to result from changes in the synaptic effectiveness of the afferent terminals than from conduction failure because of PAD.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>11131505</pmid><doi>10.1007/s002210000524</doi><tpages>11</tpages></addata></record> |
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| subjects | Action Potentials - physiology Animals Biological and medical sciences Cats Central nervous system Central neurotransmission. Neuromudulation. Pathways and receptors Clarke's column Differential Threshold Electric Stimulation Electrophysiology Fundamental and applied biological sciences. Psychology Muscle, Skeletal - innervation Nerve Fibers - physiology Nervous System Physiological Phenomena Neural Conduction - physiology Neurons, Afferent - physiology Refractory Period, Electrophysiological Spinal Cord - cytology Spinal Cord - physiology Time Factors Vertebrates: nervous system and sense organs |
| title | Effects of PAD on conduction of action potentials within segmental and ascending branches of single muscle afferents in the cat spinal cord |
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