Leukocyte Adhesiveness/Aggregation and Neuroleptic Drug Treatment
Leukocyte adhesiveness/aggregation as measured by the leukergy test was studied in peripheral citrated blood of two groups of schizophrenic patients treated with neuroleptic drugs. In the first group (N=25) leukergy test was performed before and after commencement of neuroleptic treatment to acutely...
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| Veröffentlicht in: | International clinical psychopharmacology 1991, Vol.6 (2), p.111-116 |
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| container_end_page | 116 |
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| container_title | International clinical psychopharmacology |
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| creator | ZEMISHLANY, Z AIZENBERG, D BARUCH, Y ARONSON, M |
| description | Leukocyte adhesiveness/aggregation as measured by the leukergy test was studied in peripheral citrated blood of two groups of schizophrenic patients treated with neuroleptic drugs. In the first group (N=25) leukergy test was performed before and after commencement of neuroleptic treatment to acutely psychotic hospitalized patients. The second group studied (N=25) were stabilized outpatients receiving long term neuroleptic medications for at least 3 months.There was a significant rise in leukergy rates between the drug free period and the subsequent measurements performed after 1 and 7 days of neuroleptic treatment in the first group (p < 0 011). Similar high leukergy rates were noted in the second group of remitted patients. High leukergy rates were related to neuroleptic therapy and not to the psychotic state of the patients. |
| doi_str_mv | 10.1097/00004850-199100620-00006 |
| format | Article |
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In the first group (N=25) leukergy test was performed before and after commencement of neuroleptic treatment to acutely psychotic hospitalized patients. The second group studied (N=25) were stabilized outpatients receiving long term neuroleptic medications for at least 3 months.There was a significant rise in leukergy rates between the drug free period and the subsequent measurements performed after 1 and 7 days of neuroleptic treatment in the first group (p < 0 011). Similar high leukergy rates were noted in the second group of remitted patients. High leukergy rates were related to neuroleptic therapy and not to the psychotic state of the patients.</description><identifier>ISSN: 0268-1315</identifier><identifier>EISSN: 1473-5857</identifier><identifier>DOI: 10.1097/00004850-199100620-00006</identifier><identifier>PMID: 1683666</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott-Raven Publishers</publisher><subject>Adult ; Antipsychotic Agents - therapeutic use ; Biological and medical sciences ; Cell Adhesion - drug effects ; Cell Aggregation - drug effects ; Drug toxicity and drugs side effects treatment ; Humans ; Leukocytes - drug effects ; Leukocytes - physiology ; Medical sciences ; Middle Aged ; Pharmacology. 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In the first group (N=25) leukergy test was performed before and after commencement of neuroleptic treatment to acutely psychotic hospitalized patients. The second group studied (N=25) were stabilized outpatients receiving long term neuroleptic medications for at least 3 months.There was a significant rise in leukergy rates between the drug free period and the subsequent measurements performed after 1 and 7 days of neuroleptic treatment in the first group (p < 0 011). Similar high leukergy rates were noted in the second group of remitted patients. High leukergy rates were related to neuroleptic therapy and not to the psychotic state of the patients.</description><subject>Adult</subject><subject>Antipsychotic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cell Adhesion - drug effects</subject><subject>Cell Aggregation - drug effects</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Humans</subject><subject>Leukocytes - drug effects</subject><subject>Leukocytes - physiology</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Pharmacology. Drug treatments</subject><subject>Schizophrenia - blood</subject><subject>Schizophrenia - drug therapy</subject><subject>Toxicity: blood</subject><issn>0268-1315</issn><issn>1473-5857</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kclOwzAQhi0EKmV5BKQcELfQ8RrnWLFLFVzK2XKcSRpIk2InIN6elBQ4MZeR5v9m0T-ERBQuKaTJDIYQWkJM05QCKAbxtqT2yJSKhMdSy2SfTIEpHVNO5SE5CuEFgAFNxYRMqNJcKTUl8wX2r6377DCa5ysM1Ts2GMJsXpYeS9tVbRPZJo8esfdtjZuuctG178to6dF2a2y6E3JQ2Drg6S4fk-fbm-XVfbx4unu4mi9ix7VQMWNgM0iAZ0AVaM4ElTqlSZ6JQgiFQgorLYMkKVzOdZpC5obrKWd5YTVz_JhcjHM3vn3rMXRmXQWHdW0bbPtgEiZBU8oGUI-g820IHguz8dXa-k9DwWzdMz_umV_3vktqaD3b7eizNeZ_jaNdg36-021wti68bVwVfjEJXHGmB0yM2Edbd-jDa91_oDcrtHW3Mv_9jn8BDPaE6A</recordid><startdate>1991</startdate><enddate>1991</enddate><creator>ZEMISHLANY, Z</creator><creator>AIZENBERG, D</creator><creator>BARUCH, Y</creator><creator>ARONSON, M</creator><general>Lippincott-Raven Publishers</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1991</creationdate><title>Leukocyte Adhesiveness/Aggregation and Neuroleptic Drug Treatment</title><author>ZEMISHLANY, Z ; AIZENBERG, D ; BARUCH, Y ; ARONSON, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3846-220ab0703b01608324158917db4f446e454a5a2077fcd38990bc268132dfa82c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cell Adhesion - drug effects</topic><topic>Cell Aggregation - drug effects</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Humans</topic><topic>Leukocytes - drug effects</topic><topic>Leukocytes - physiology</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Pharmacology. Drug treatments</topic><topic>Schizophrenia - blood</topic><topic>Schizophrenia - drug therapy</topic><topic>Toxicity: blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ZEMISHLANY, Z</creatorcontrib><creatorcontrib>AIZENBERG, D</creatorcontrib><creatorcontrib>BARUCH, Y</creatorcontrib><creatorcontrib>ARONSON, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International clinical psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ZEMISHLANY, Z</au><au>AIZENBERG, D</au><au>BARUCH, Y</au><au>ARONSON, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Leukocyte Adhesiveness/Aggregation and Neuroleptic Drug Treatment</atitle><jtitle>International clinical psychopharmacology</jtitle><addtitle>Int Clin Psychopharmacol</addtitle><date>1991</date><risdate>1991</risdate><volume>6</volume><issue>2</issue><spage>111</spage><epage>116</epage><pages>111-116</pages><issn>0268-1315</issn><eissn>1473-5857</eissn><abstract>Leukocyte adhesiveness/aggregation as measured by the leukergy test was studied in peripheral citrated blood of two groups of schizophrenic patients treated with neuroleptic drugs. In the first group (N=25) leukergy test was performed before and after commencement of neuroleptic treatment to acutely psychotic hospitalized patients. The second group studied (N=25) were stabilized outpatients receiving long term neuroleptic medications for at least 3 months.There was a significant rise in leukergy rates between the drug free period and the subsequent measurements performed after 1 and 7 days of neuroleptic treatment in the first group (p < 0 011). Similar high leukergy rates were noted in the second group of remitted patients. High leukergy rates were related to neuroleptic therapy and not to the psychotic state of the patients.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott-Raven Publishers</pub><pmid>1683666</pmid><doi>10.1097/00004850-199100620-00006</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0268-1315 |
| ispartof | International clinical psychopharmacology, 1991, Vol.6 (2), p.111-116 |
| issn | 0268-1315 1473-5857 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Antipsychotic Agents - therapeutic use Biological and medical sciences Cell Adhesion - drug effects Cell Aggregation - drug effects Drug toxicity and drugs side effects treatment Humans Leukocytes - drug effects Leukocytes - physiology Medical sciences Middle Aged Pharmacology. Drug treatments Schizophrenia - blood Schizophrenia - drug therapy Toxicity: blood |
| title | Leukocyte Adhesiveness/Aggregation and Neuroleptic Drug Treatment |
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