The pleomorphic xanthoastrocytoma and its differential diagnosis: A study of five cases
Five brain tumors with the histopathologic features of pleomorphic xanthoastrocytomas (PXAs) are presented. Computed tomography scans showed a remarkable homology. Two cases had atypical localizations for a PXA, while one 46-year-old patient did not conform to the normal age distribution of this tum...
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| Veröffentlicht in: | Human pathology 1991-11, Vol.22 (11), p.1128-1135 |
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| creator | Kros, Johan M. Vecht, Charles J. Stefanko, Stanislav Z. |
| description | Five brain tumors with the histopathologic features of pleomorphic xanthoastrocytomas (PXAs) are presented. Computed tomography scans showed a remarkable homology. Two cases had atypical localizations for a PXA, while one 46-year-old patient did not conform to the normal age distribution of this tumor. Nevertheless, in these cases, the histopathology was always characteristic for PXA, a remarkable pleomorphism, in addition to simultaneous expression of glial fibrillary acidic protein and histiocytic markers in the various tumor cells. In one of the presented tumors, however, clusters of neoplastic neuronal cells were also found. In this particular case, differential diagnostic criteria to distinguish between a PXA and a desmoplastic infantile ganglioglioma are lacking. |
| doi_str_mv | 10.1016/0046-8177(91)90265-Q |
| format | Article |
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Computed tomography scans showed a remarkable homology. Two cases had atypical localizations for a PXA, while one 46-year-old patient did not conform to the normal age distribution of this tumor. Nevertheless, in these cases, the histopathology was always characteristic for PXA, a remarkable pleomorphism, in addition to simultaneous expression of glial fibrillary acidic protein and histiocytic markers in the various tumor cells. In one of the presented tumors, however, clusters of neoplastic neuronal cells were also found. In this particular case, differential diagnostic criteria to distinguish between a PXA and a desmoplastic infantile ganglioglioma are lacking.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/0046-8177(91)90265-Q</identifier><identifier>PMID: 1743696</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Astrocytoma - chemistry ; Astrocytoma - diagnostic imaging ; Astrocytoma - pathology ; Biological and medical sciences ; Brain Neoplasms - chemistry ; Brain Neoplasms - diagnostic imaging ; Brain Neoplasms - pathology ; Child ; desmoplastic infantile ganglioglioma ; Diagnosis, Differential ; Female ; ganglioglioma ; glioma ; Humans ; Immunohistochemistry ; Male ; Medical sciences ; Middle Aged ; Neurology ; pleomorphic xanthoastrocytoma ; Tomography, X-Ray Computed</subject><ispartof>Human pathology, 1991-11, Vol.22 (11), p.1128-1135</ispartof><rights>1991</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413q-59112e3e693d9013b964e733562473191dc7acf24a28ed4c7c21adca8a6fe9843</citedby><cites>FETCH-LOGICAL-c413q-59112e3e693d9013b964e733562473191dc7acf24a28ed4c7c21adca8a6fe9843</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/004681779190265Q$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5492038$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1743696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kros, Johan M.</creatorcontrib><creatorcontrib>Vecht, Charles J.</creatorcontrib><creatorcontrib>Stefanko, Stanislav Z.</creatorcontrib><title>The pleomorphic xanthoastrocytoma and its differential diagnosis: A study of five cases</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>Five brain tumors with the histopathologic features of pleomorphic xanthoastrocytomas (PXAs) are presented. Computed tomography scans showed a remarkable homology. Two cases had atypical localizations for a PXA, while one 46-year-old patient did not conform to the normal age distribution of this tumor. Nevertheless, in these cases, the histopathology was always characteristic for PXA, a remarkable pleomorphism, in addition to simultaneous expression of glial fibrillary acidic protein and histiocytic markers in the various tumor cells. In one of the presented tumors, however, clusters of neoplastic neuronal cells were also found. In this particular case, differential diagnostic criteria to distinguish between a PXA and a desmoplastic infantile ganglioglioma are lacking.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Astrocytoma - chemistry</subject><subject>Astrocytoma - diagnostic imaging</subject><subject>Astrocytoma - pathology</subject><subject>Biological and medical sciences</subject><subject>Brain Neoplasms - chemistry</subject><subject>Brain Neoplasms - diagnostic imaging</subject><subject>Brain Neoplasms - pathology</subject><subject>Child</subject><subject>desmoplastic infantile ganglioglioma</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>ganglioglioma</subject><subject>glioma</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>pleomorphic xanthoastrocytoma</subject><subject>Tomography, X-Ray Computed</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rFEEQhhtR4ib6DxT6IKKH0f6a6WkPQgjxAwISiHhsKt3VbsvM9KZrNrj_3ll3iTdPRVHP-1I8jL2Q4p0UsnsvhOmaXlr7xsm3Tqiuba4fsZVstWp67dRjtnpAnrJTol9CSNma9oSdSGt057oV-3GzRr4ZsIylbtY58N8wzesCNNcSdnMZgcMUeZ6Jx5wSVpzmDMOywM-pUKYP_JzTvI07XhJP-R55AEJ6xp4kGAifH-cZ-_7p8ubiS3P17fPXi_OrJhip75rWSalQY-d0dELqW9cZtFq3nTJWSydjsBCSMqB6jCbYoCTEAD10CV1v9Bl7fejd1HK3RZr9mCngMMCEZUveqlZY4fagOYChFqKKyW9qHqHuvBR-79PvZfm9LO-k_-vTXy-xl8f-7e2I8V_oIHC5vzregQIMqcIUMj1grXFK6H7BPh4wXFzcZ6yeQsYpYMwVw-xjyf__4w8sxpGO</recordid><startdate>199111</startdate><enddate>199111</enddate><creator>Kros, Johan M.</creator><creator>Vecht, Charles J.</creator><creator>Stefanko, Stanislav Z.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199111</creationdate><title>The pleomorphic xanthoastrocytoma and its differential diagnosis: A study of five cases</title><author>Kros, Johan M. ; Vecht, Charles J. ; Stefanko, Stanislav Z.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413q-59112e3e693d9013b964e733562473191dc7acf24a28ed4c7c21adca8a6fe9843</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Astrocytoma - chemistry</topic><topic>Astrocytoma - diagnostic imaging</topic><topic>Astrocytoma - pathology</topic><topic>Biological and medical sciences</topic><topic>Brain Neoplasms - chemistry</topic><topic>Brain Neoplasms - diagnostic imaging</topic><topic>Brain Neoplasms - pathology</topic><topic>Child</topic><topic>desmoplastic infantile ganglioglioma</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>ganglioglioma</topic><topic>glioma</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>pleomorphic xanthoastrocytoma</topic><topic>Tomography, X-Ray Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kros, Johan M.</creatorcontrib><creatorcontrib>Vecht, Charles J.</creatorcontrib><creatorcontrib>Stefanko, Stanislav Z.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kros, Johan M.</au><au>Vecht, Charles J.</au><au>Stefanko, Stanislav Z.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The pleomorphic xanthoastrocytoma and its differential diagnosis: A study of five cases</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>1991-11</date><risdate>1991</risdate><volume>22</volume><issue>11</issue><spage>1128</spage><epage>1135</epage><pages>1128-1135</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>Five brain tumors with the histopathologic features of pleomorphic xanthoastrocytomas (PXAs) are presented. Computed tomography scans showed a remarkable homology. Two cases had atypical localizations for a PXA, while one 46-year-old patient did not conform to the normal age distribution of this tumor. Nevertheless, in these cases, the histopathology was always characteristic for PXA, a remarkable pleomorphism, in addition to simultaneous expression of glial fibrillary acidic protein and histiocytic markers in the various tumor cells. In one of the presented tumors, however, clusters of neoplastic neuronal cells were also found. In this particular case, differential diagnostic criteria to distinguish between a PXA and a desmoplastic infantile ganglioglioma are lacking.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>1743696</pmid><doi>10.1016/0046-8177(91)90265-Q</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Human pathology, 1991-11, Vol.22 (11), p.1128-1135 |
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| language | eng |
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| subjects | Adolescent Adult Astrocytoma - chemistry Astrocytoma - diagnostic imaging Astrocytoma - pathology Biological and medical sciences Brain Neoplasms - chemistry Brain Neoplasms - diagnostic imaging Brain Neoplasms - pathology Child desmoplastic infantile ganglioglioma Diagnosis, Differential Female ganglioglioma glioma Humans Immunohistochemistry Male Medical sciences Middle Aged Neurology pleomorphic xanthoastrocytoma Tomography, X-Ray Computed |
| title | The pleomorphic xanthoastrocytoma and its differential diagnosis: A study of five cases |
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