Intravaginal Prostaglandin E2 Gel and Cardiovascular Changes in Hypertensive Pregnancies
ABSTRACT Prostaglandin E 2 (PGE 2 ) and its analogues may be potent vasodilators, and intravaginal PGE 2 is known to be absorbed rapidly into the maternal circulation. This study investigated any cardiovascular effects from intravaginal PGE 2 on 42 hypertensive pregnant women requiring preinduction...
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| Veröffentlicht in: | American journal of perinatology 1991-07, Vol.8 (4), p.233-235 |
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| container_title | American journal of perinatology |
| container_volume | 8 |
| creator | Rayburn, William Woods, Ralph Ramadei, Cynthia |
| description | ABSTRACT
Prostaglandin E
2
(PGE
2
) and its analogues may be potent vasodilators, and intravaginal PGE
2
is known to be absorbed rapidly into the maternal circulation. This study investigated any cardiovascular effects from intravaginal PGE
2
on 42 hypertensive pregnant women requiring preinduction cervical ripening. Declines in maternal diastolic, systolic, and mean arterial pressures were apparent during the first half hour. This trend was mild, was reversible without treatment, and did not influence the fetal heart rate baseline or patterns. Fear of clinically significant changes should not be a concern, but monitoring during the first hour is recommended. |
| doi_str_mv | 10.1055/s-2007-999385 |
| format | Article |
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Prostaglandin E
2
(PGE
2
) and its analogues may be potent vasodilators, and intravaginal PGE
2
is known to be absorbed rapidly into the maternal circulation. This study investigated any cardiovascular effects from intravaginal PGE
2
on 42 hypertensive pregnant women requiring preinduction cervical ripening. Declines in maternal diastolic, systolic, and mean arterial pressures were apparent during the first half hour. This trend was mild, was reversible without treatment, and did not influence the fetal heart rate baseline or patterns. Fear of clinically significant changes should not be a concern, but monitoring during the first hour is recommended.</description><identifier>ISSN: 0735-1631</identifier><identifier>EISSN: 1098-8785</identifier><identifier>DOI: 10.1055/s-2007-999385</identifier><identifier>PMID: 1741863</identifier><identifier>CODEN: AJPEEK</identifier><language>eng</language><publisher>New York, NY: Thieme</publisher><subject>Administration, Intravaginal ; Adolescent ; Adult ; Biological and medical sciences ; Blood Pressure - drug effects ; Cervix Uteri - drug effects ; Chronic Disease ; Dinoprostone - administration & dosage ; Dinoprostone - pharmacology ; Dinoprostone - therapeutic use ; Female ; Gels ; Gynecology. Andrology. Obstetrics ; Heart Rate - drug effects ; Humans ; Hypertension - physiopathology ; Labor, Induced - methods ; Medical sciences ; Monitoring, Physiologic ; ORIGINAL ARTICLE ; Pre-Eclampsia - physiopathology ; Pregnancy ; Pregnancy Complications, Cardiovascular - physiopathology</subject><ispartof>American journal of perinatology, 1991-07, Vol.8 (4), p.233-235</ispartof><rights>1991 by Thieme Medical Publishers, Inc.</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-999385.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><linktohtml>$$Uhttps://www.thieme-connect.de/products/ejournals/html/10.1055/s-2007-999385$$EHTML$$P50$$Gthieme$$H</linktohtml><link.rule.ids>314,777,781,3005,27905,27906,54540,54541</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5306636$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1741863$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rayburn, William</creatorcontrib><creatorcontrib>Woods, Ralph</creatorcontrib><creatorcontrib>Ramadei, Cynthia</creatorcontrib><title>Intravaginal Prostaglandin E2 Gel and Cardiovascular Changes in Hypertensive Pregnancies</title><title>American journal of perinatology</title><addtitle>Amer J Perinatol</addtitle><description>ABSTRACT
Prostaglandin E
2
(PGE
2
) and its analogues may be potent vasodilators, and intravaginal PGE
2
is known to be absorbed rapidly into the maternal circulation. This study investigated any cardiovascular effects from intravaginal PGE
2
on 42 hypertensive pregnant women requiring preinduction cervical ripening. Declines in maternal diastolic, systolic, and mean arterial pressures were apparent during the first half hour. This trend was mild, was reversible without treatment, and did not influence the fetal heart rate baseline or patterns. Fear of clinically significant changes should not be a concern, but monitoring during the first hour is recommended.</description><subject>Administration, Intravaginal</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cervix Uteri - drug effects</subject><subject>Chronic Disease</subject><subject>Dinoprostone - administration & dosage</subject><subject>Dinoprostone - pharmacology</subject><subject>Dinoprostone - therapeutic use</subject><subject>Female</subject><subject>Gels</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Heart Rate - drug effects</subject><subject>Humans</subject><subject>Hypertension - physiopathology</subject><subject>Labor, Induced - methods</subject><subject>Medical sciences</subject><subject>Monitoring, Physiologic</subject><subject>ORIGINAL ARTICLE</subject><subject>Pre-Eclampsia - physiopathology</subject><subject>Pregnancy</subject><subject>Pregnancy Complications, Cardiovascular - physiopathology</subject><issn>0735-1631</issn><issn>1098-8785</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kU1Lw0AQhhdRaq0ePQo5iCej-9HNbo4Salso6EHB2zJJNmlKsom7SaH_3g0NwjDDMM8MvPMidE_wC8Gcv7qQYizCOI6Z5BdoTnAsQykkv0RzLBgPScTINbpx7oAxoRLLGZoRsSQyYnP0szW9hSOUlYE6-LSt66GsweSVCVY0WOs68E2QgM2r9gguG2qwQbIHU2oXeGhz6rTttXHVUft9XRowWaXdLboqoHb6bqoL9P2--ko24e5jvU3edmFHBe3DVON8SYEzUXAKOZHLOB1TzgohY2AxZwAxlSnLeQaUZgVnklGeCVLQDFK2QE_nu51tfwftetVULtO116DbwSlBOY58ePBhAoe00bnqbNWAPanpFX7-OM29SqgLO-pw_xhnOIrYeOb5jPX7SjdaHdrB-tc5RbAa_VBOjX6osx_sD1Lfeq0</recordid><startdate>19910701</startdate><enddate>19910701</enddate><creator>Rayburn, William</creator><creator>Woods, Ralph</creator><creator>Ramadei, Cynthia</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19910701</creationdate><title>Intravaginal Prostaglandin E2 Gel and Cardiovascular Changes in Hypertensive Pregnancies</title><author>Rayburn, William ; Woods, Ralph ; Ramadei, Cynthia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p272t-be0d42a537f52ad1849b1849d3f789a3953aa928b3d5ca22cf538325c71f2cab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Administration, Intravaginal</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Cervix Uteri - drug effects</topic><topic>Chronic Disease</topic><topic>Dinoprostone - administration & dosage</topic><topic>Dinoprostone - pharmacology</topic><topic>Dinoprostone - therapeutic use</topic><topic>Female</topic><topic>Gels</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Heart Rate - drug effects</topic><topic>Humans</topic><topic>Hypertension - physiopathology</topic><topic>Labor, Induced - methods</topic><topic>Medical sciences</topic><topic>Monitoring, Physiologic</topic><topic>ORIGINAL ARTICLE</topic><topic>Pre-Eclampsia - physiopathology</topic><topic>Pregnancy</topic><topic>Pregnancy Complications, Cardiovascular - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rayburn, William</creatorcontrib><creatorcontrib>Woods, Ralph</creatorcontrib><creatorcontrib>Ramadei, Cynthia</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rayburn, William</au><au>Woods, Ralph</au><au>Ramadei, Cynthia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Intravaginal Prostaglandin E2 Gel and Cardiovascular Changes in Hypertensive Pregnancies</atitle><jtitle>American journal of perinatology</jtitle><addtitle>Amer J Perinatol</addtitle><date>1991-07-01</date><risdate>1991</risdate><volume>8</volume><issue>4</issue><spage>233</spage><epage>235</epage><pages>233-235</pages><issn>0735-1631</issn><eissn>1098-8785</eissn><coden>AJPEEK</coden><abstract>ABSTRACT
Prostaglandin E
2
(PGE
2
) and its analogues may be potent vasodilators, and intravaginal PGE
2
is known to be absorbed rapidly into the maternal circulation. This study investigated any cardiovascular effects from intravaginal PGE
2
on 42 hypertensive pregnant women requiring preinduction cervical ripening. Declines in maternal diastolic, systolic, and mean arterial pressures were apparent during the first half hour. This trend was mild, was reversible without treatment, and did not influence the fetal heart rate baseline or patterns. Fear of clinically significant changes should not be a concern, but monitoring during the first hour is recommended.</abstract><cop>New York, NY</cop><pub>Thieme</pub><pmid>1741863</pmid><doi>10.1055/s-2007-999385</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0735-1631 |
| ispartof | American journal of perinatology, 1991-07, Vol.8 (4), p.233-235 |
| issn | 0735-1631 1098-8785 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72506506 |
| source | MEDLINE; Thieme Connect Journals |
| subjects | Administration, Intravaginal Adolescent Adult Biological and medical sciences Blood Pressure - drug effects Cervix Uteri - drug effects Chronic Disease Dinoprostone - administration & dosage Dinoprostone - pharmacology Dinoprostone - therapeutic use Female Gels Gynecology. Andrology. Obstetrics Heart Rate - drug effects Humans Hypertension - physiopathology Labor, Induced - methods Medical sciences Monitoring, Physiologic ORIGINAL ARTICLE Pre-Eclampsia - physiopathology Pregnancy Pregnancy Complications, Cardiovascular - physiopathology |
| title | Intravaginal Prostaglandin E2 Gel and Cardiovascular Changes in Hypertensive Pregnancies |
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