Molecular genetic evidence for a differentiation-proliferation coupling during DMSO-induced myeloid maturation of HL-60 cells: Role of the transcription elongation block in the c- myc gene

Proliferation-differentiation coupling was studied during dimethyl sulfoxide (DMSO)-induced myeloid maturation of HL-60 cells using transcription of the myeloperoxidase ( MPO) and c- myc genes as indicators of differentiation and proliferation, respectively. Concomitant cell cycle kinetic analysis c...

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Veröffentlicht in:	Leukemia research 1991, Vol.15 (11), p.1029-1036
Hauptverfasser:	Antoun, Gamil R., Re, Gian G., Terry, Nicholas H.A., Zipf, Theodore F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - genetics Biological and medical sciences Blotting, Northern c- myc gene Cell Cycle Cell Differentiation - drug effects Cell differentiation, maturation, development, hematopoiesis Cell Division - drug effects Cell physiology Dimethyl Sulfoxide - pharmacology Fundamental and applied biological sciences. Psychology Gene Expression Genes, myc HL-60 Leukemia, Promyelocytic, Acute Molecular and cellular biology myeloperoxidase gene Peroxidase - genetics proliferation-differentiation coupling RNA, Messenger - analysis transcription elongation Transcription, Genetic Tumor Cells, Cultured - drug effects
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