Purification and characterization of a Kunitz-type trypsin inhibitor from Leaf-nosed viper venom
A Kunitz-type trypsin inhibitor was purified from Leaf-nosed viper venom and the primary structure determined by peptide analysis. In relation to other trypsin inhibitors, the protein has an extended C-terminal segment and a distinct pattern of residue alterations at the functionally important conta...
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| Veröffentlicht in: | FEBS letters 1991-12, Vol.294 (1), p.141-143 |
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| container_title | FEBS letters |
| container_volume | 294 |
| creator | Siddiqi, Abdur Rehman Zaidi, Zafar H. Jörnvall, Hans |
| description | A Kunitz-type trypsin inhibitor was purified from Leaf-nosed viper venom and the primary structure determined by peptide analysis. In relation to other trypsin inhibitors, the protein has an extended C-terminal segment and a distinct pattern of residue alterations at the functionally important contact sites with proteases. |
| doi_str_mv | 10.1016/0014-5793(91)81361-B |
| format | Article |
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In relation to other trypsin inhibitors, the protein has an extended C-terminal segment and a distinct pattern of residue alterations at the functionally important contact sites with proteases.</description><subject>Amino Acid Sequence</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>C-terminal extension</subject><subject>Chromatography, High Pressure Liquid - methods</subject><subject>Contact site</subject><subject>Enzymes and enzyme inhibitors</subject><subject>Fundamental and applied biological sciences. 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| ispartof | FEBS letters, 1991-12, Vol.294 (1), p.141-143 |
| issn | 0014-5793 1873-3468 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72505468 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Analytical, structural and metabolic biochemistry Animals Biological and medical sciences C-terminal extension Chromatography, High Pressure Liquid - methods Contact site Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Homology Hydrolases Molecular Sequence Data Sequence Homology, Nucleic Acid Serpentes Snakes Trypsin inhibitor Trypsin Inhibitor, Kunitz Soybean - chemistry Trypsin Inhibitors - chemistry Trypsin Inhibitors - isolation & purification Viper Venoms |
| title | Purification and characterization of a Kunitz-type trypsin inhibitor from Leaf-nosed viper venom |
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