Effects of bestatin (Ubenimex) on human T-cell colony formation
The antitumor action of bestatin is considered to be an indirect action mediated by T-cells. Therefore, we investigated the effects of bestatin on the differentiation and proliferation of human precursor T-cells using a colony formation technique. Bestatin did not increase the overall number of T-ce...
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| Veröffentlicht in: | Anti-cancer drugs 1991-02, Vol.2 (1), p.39-44 |
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| container_title | Anti-cancer drugs |
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| creator | Wakabayashi, Yoshihisa Hashimoto, Manabu Saitoh, Kiyoshi Osawa, Hideki Koike, Michiaki Hirose, Shun-ichi |
| description | The antitumor action of bestatin is considered to be an indirect action mediated by T-cells. Therefore, we investigated the effects of bestatin on the differentiation and proliferation of human precursor T-cells using a colony formation technique. Bestatin did not increase the overall number of T-cell colonies, but it significantly increased in CD4 cell and significantly decreased in CD8 cell subpopulations. It also induced CD4 8 cells.These findings indicated that bestatin acts on precursor T-cells to induce the differentiation of these cells into CD4 cells. |
| doi_str_mv | 10.1097/00001813-199102000-00005 |
| format | Article |
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Hashimoto, Manabu ; Saitoh, Kiyoshi ; Osawa, Hideki ; Koike, Michiaki ; Hirose, Shun-ichi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3555-77066d8a5cf377c5736b413021af0b93400731df0ed8a7bf2c2a1f1f517c2b293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Adult</topic><topic>Antibiotics, Antineoplastic - pharmacology</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Antigens, Differentiation, T-Lymphocyte - immunology</topic><topic>CD3 Complex</topic><topic>CD4 Antigens - immunology</topic><topic>CD8 Antigens - immunology</topic><topic>Cell Differentiation - drug effects</topic><topic>Cell Division - drug effects</topic><topic>Cells, Cultured</topic><topic>Hematopoietic Stem Cells - drug effects</topic><topic>Humans</topic><topic>Leucine - analogs & derivatives</topic><topic>Leucine - pharmacology</topic><topic>Receptors, Antigen, T-Cell - immunology</topic><topic>T-Lymphocyte Subsets - cytology</topic><topic>T-Lymphocyte Subsets - drug effects</topic><topic>T-Lymphocytes - cytology</topic><topic>T-Lymphocytes - drug effects</topic><topic>T-Lymphocytes - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wakabayashi, Yoshihisa</creatorcontrib><creatorcontrib>Hashimoto, Manabu</creatorcontrib><creatorcontrib>Saitoh, Kiyoshi</creatorcontrib><creatorcontrib>Osawa, Hideki</creatorcontrib><creatorcontrib>Koike, Michiaki</creatorcontrib><creatorcontrib>Hirose, Shun-ichi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anti-cancer drugs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wakabayashi, Yoshihisa</au><au>Hashimoto, Manabu</au><au>Saitoh, Kiyoshi</au><au>Osawa, Hideki</au><au>Koike, Michiaki</au><au>Hirose, Shun-ichi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of bestatin (Ubenimex) on human T-cell colony formation</atitle><jtitle>Anti-cancer drugs</jtitle><addtitle>Anticancer Drugs</addtitle><date>1991-02</date><risdate>1991</risdate><volume>2</volume><issue>1</issue><spage>39</spage><epage>44</epage><pages>39-44</pages><issn>0959-4973</issn><eissn>1473-5741</eissn><abstract>The antitumor action of bestatin is considered to be an indirect action mediated by T-cells. Therefore, we investigated the effects of bestatin on the differentiation and proliferation of human precursor T-cells using a colony formation technique. Bestatin did not increase the overall number of T-cell colonies, but it significantly increased in CD4 cell and significantly decreased in CD8 cell subpopulations. It also induced CD4 8 cells.These findings indicated that bestatin acts on precursor T-cells to induce the differentiation of these cells into CD4 cells.</abstract><cop>England</cop><pub>Lippincott-Raven Publishers</pub><pmid>1835660</pmid><doi>10.1097/00001813-199102000-00005</doi><tpages>6</tpages></addata></record> |
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| ispartof | Anti-cancer drugs, 1991-02, Vol.2 (1), p.39-44 |
| issn | 0959-4973 1473-5741 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Antibiotics, Antineoplastic - pharmacology Antibodies, Monoclonal - immunology Antigens, Differentiation, T-Lymphocyte - immunology CD3 Complex CD4 Antigens - immunology CD8 Antigens - immunology Cell Differentiation - drug effects Cell Division - drug effects Cells, Cultured Hematopoietic Stem Cells - drug effects Humans Leucine - analogs & derivatives Leucine - pharmacology Receptors, Antigen, T-Cell - immunology T-Lymphocyte Subsets - cytology T-Lymphocyte Subsets - drug effects T-Lymphocytes - cytology T-Lymphocytes - drug effects T-Lymphocytes - immunology |
| title | Effects of bestatin (Ubenimex) on human T-cell colony formation |
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