Neonatal thymic contrasuppressor activity on graft versus host reactions towards self histocompatibility antigens. Parental effects
The ability of fetal and neonatal F1 thymocytes to regulate parental graft versus host (GvH) reactions against self histocompatibility antigens was investigated. The results obtained showed that: (1) fetal F1 thymocytes were able to suppress both maternal and paternal GvH reactivity; (2) at birth, t...
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| Veröffentlicht in: | Journal of reproductive immunology 1991-09, Vol.20 (3), p.237-251 |
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| container_title | Journal of reproductive immunology |
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| creator | Torello, Sandra Déroche, Adriana Nepomnaschy, Irene Buggiano, Valeria Goldman, Alejandra Piazzon, Isabel |
| description | The ability of fetal and neonatal F1 thymocytes to regulate parental graft versus host (GvH) reactions against self histocompatibility antigens was investigated. The results obtained showed that: (1) fetal F1 thymocytes were able to suppress both maternal and paternal GvH reactivity; (2) at birth, thymocytes were still able to suppress maternal GvH reactivity while no suppression of paternal reactions was detected; the ability to suppress maternal GvH reactions could be detected until day 3; (3) the loss of suppressor activity correlated with the ability of thymocytes to contrasuppress parental GvH reactions. Thus, 24-h F1 thymocytes showed contrasuppressor activity on paternal GvH reactivity and 4-day thymocytes on maternal reactivity. Thymic cells with contrasuppressor activity were shown to be Lyt-1
+, CD4
+, CD8
− and adherent to
Vicia villosa. These results suggest the existence of parental effects influencing the duration of thymic suppression and the subsequent appearance of contrasuppressor activity on GvH reactions against self histocompatibility antigens, according to the maternal or paternal origin of self antigens towards which the reaction is directed. |
| doi_str_mv | 10.1016/0165-0378(91)90049-V |
| format | Article |
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+, CD4
+, CD8
− and adherent to
Vicia villosa. These results suggest the existence of parental effects influencing the duration of thymic suppression and the subsequent appearance of contrasuppressor activity on GvH reactions against self histocompatibility antigens, according to the maternal or paternal origin of self antigens towards which the reaction is directed.</description><identifier>ISSN: 0165-0378</identifier><identifier>EISSN: 1872-7603</identifier><identifier>DOI: 10.1016/0165-0378(91)90049-V</identifier><identifier>PMID: 1960705</identifier><identifier>CODEN: JRIMDR</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Animals ; Animals, Newborn - immunology ; Autoantigens - immunology ; Biological and medical sciences ; CD4 Antigens ; CD8 Antigens ; Crosses, Genetic ; Female ; Graft vs Host Reaction - genetics ; Graft vs Host Reaction - immunology ; Histocompatibility Antigens - genetics ; Histocompatibility Antigens - immunology ; Intensive care medicine ; Lectins - immunology ; Lymph Nodes - immunology ; Medical sciences ; Mice ; Mice, Inbred Strains ; Plant Lectins ; Pregnancy ; Receptors, Mitogen - immunology ; Suppressor Factors, Immunologic - immunology ; Thymus Gland - immunology ; Thymus Gland - transplantation</subject><ispartof>Journal of reproductive immunology, 1991-09, Vol.20 (3), p.237-251</ispartof><rights>1991</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c335t-e3a4dc639f4190cd7494a97506b6a693202b68e6ca2600323be7d73dab808b443</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/016503789190049V$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5295116$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1960705$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Torello, Sandra</creatorcontrib><creatorcontrib>Déroche, Adriana</creatorcontrib><creatorcontrib>Nepomnaschy, Irene</creatorcontrib><creatorcontrib>Buggiano, Valeria</creatorcontrib><creatorcontrib>Goldman, Alejandra</creatorcontrib><creatorcontrib>Piazzon, Isabel</creatorcontrib><title>Neonatal thymic contrasuppressor activity on graft versus host reactions towards self histocompatibility antigens. Parental effects</title><title>Journal of reproductive immunology</title><addtitle>J Reprod Immunol</addtitle><description>The ability of fetal and neonatal F1 thymocytes to regulate parental graft versus host (GvH) reactions against self histocompatibility antigens was investigated. The results obtained showed that: (1) fetal F1 thymocytes were able to suppress both maternal and paternal GvH reactivity; (2) at birth, thymocytes were still able to suppress maternal GvH reactivity while no suppression of paternal reactions was detected; the ability to suppress maternal GvH reactions could be detected until day 3; (3) the loss of suppressor activity correlated with the ability of thymocytes to contrasuppress parental GvH reactions. Thus, 24-h F1 thymocytes showed contrasuppressor activity on paternal GvH reactivity and 4-day thymocytes on maternal reactivity. Thymic cells with contrasuppressor activity were shown to be Lyt-1
+, CD4
+, CD8
− and adherent to
Vicia villosa. These results suggest the existence of parental effects influencing the duration of thymic suppression and the subsequent appearance of contrasuppressor activity on GvH reactions against self histocompatibility antigens, according to the maternal or paternal origin of self antigens towards which the reaction is directed.</description><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Animals, Newborn - immunology</subject><subject>Autoantigens - immunology</subject><subject>Biological and medical sciences</subject><subject>CD4 Antigens</subject><subject>CD8 Antigens</subject><subject>Crosses, Genetic</subject><subject>Female</subject><subject>Graft vs Host Reaction - genetics</subject><subject>Graft vs Host Reaction - immunology</subject><subject>Histocompatibility Antigens - genetics</subject><subject>Histocompatibility Antigens - immunology</subject><subject>Intensive care medicine</subject><subject>Lectins - immunology</subject><subject>Lymph Nodes - immunology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Plant Lectins</subject><subject>Pregnancy</subject><subject>Receptors, Mitogen - immunology</subject><subject>Suppressor Factors, Immunologic - immunology</subject><subject>Thymus Gland - immunology</subject><subject>Thymus Gland - transplantation</subject><issn>0165-0378</issn><issn>1872-7603</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMFu1DAQhiMEKtvCG4DkA0JwSBnHiR1fkFBFAakCDtCr5TiTrlFiLx5n0Z55cRJ2VW4cRj783z9jfUXxjMMlBy7fLNOUIFT7SvPXGqDW5e2DYsNbVZVKgnhYbO6Rx8U50Q8ArkDzs-KMawkKmk3x-zPGYLMdWd4eJu-YiyEnS_Nul5AoJmZd9nufDywGdpfskNkeE83EtpEyS7jmMRDL8ZdNPTHCcWBbTzm6OO1s9p0f17oN2d9hoEv21SYM60kcBnSZnhSPBjsSPj29F8X36_ffrj6WN18-fLp6d1M6IZpcorB176TQQ801uF7VurZaNSA7aaUWFVSdbFE6W0kAUYkOVa9Eb7sW2q6uxUXx8rh3l-LPGSmbyZPDcbQB40xGVQ2IBtQC1kfQpUiUcDC75CebDoaDWd2bVaxZxRrNzV_35napPT_tn7sJ-3-lo-wlf3HKLTk7DskG5-keayrdcC4X7O0Rw8XF3mMy5DwGh71Piy7TR___f_wB2IOjeg</recordid><startdate>19910901</startdate><enddate>19910901</enddate><creator>Torello, Sandra</creator><creator>Déroche, Adriana</creator><creator>Nepomnaschy, Irene</creator><creator>Buggiano, Valeria</creator><creator>Goldman, Alejandra</creator><creator>Piazzon, Isabel</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19910901</creationdate><title>Neonatal thymic contrasuppressor activity on graft versus host reactions towards self histocompatibility antigens. Parental effects</title><author>Torello, Sandra ; Déroche, Adriana ; Nepomnaschy, Irene ; Buggiano, Valeria ; Goldman, Alejandra ; Piazzon, Isabel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-e3a4dc639f4190cd7494a97506b6a693202b68e6ca2600323be7d73dab808b443</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Animals, Newborn - immunology</topic><topic>Autoantigens - immunology</topic><topic>Biological and medical sciences</topic><topic>CD4 Antigens</topic><topic>CD8 Antigens</topic><topic>Crosses, Genetic</topic><topic>Female</topic><topic>Graft vs Host Reaction - genetics</topic><topic>Graft vs Host Reaction - immunology</topic><topic>Histocompatibility Antigens - genetics</topic><topic>Histocompatibility Antigens - immunology</topic><topic>Intensive care medicine</topic><topic>Lectins - immunology</topic><topic>Lymph Nodes - immunology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Plant Lectins</topic><topic>Pregnancy</topic><topic>Receptors, Mitogen - immunology</topic><topic>Suppressor Factors, Immunologic - immunology</topic><topic>Thymus Gland - immunology</topic><topic>Thymus Gland - transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Torello, Sandra</creatorcontrib><creatorcontrib>Déroche, Adriana</creatorcontrib><creatorcontrib>Nepomnaschy, Irene</creatorcontrib><creatorcontrib>Buggiano, Valeria</creatorcontrib><creatorcontrib>Goldman, Alejandra</creatorcontrib><creatorcontrib>Piazzon, Isabel</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of reproductive immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Torello, Sandra</au><au>Déroche, Adriana</au><au>Nepomnaschy, Irene</au><au>Buggiano, Valeria</au><au>Goldman, Alejandra</au><au>Piazzon, Isabel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neonatal thymic contrasuppressor activity on graft versus host reactions towards self histocompatibility antigens. Parental effects</atitle><jtitle>Journal of reproductive immunology</jtitle><addtitle>J Reprod Immunol</addtitle><date>1991-09-01</date><risdate>1991</risdate><volume>20</volume><issue>3</issue><spage>237</spage><epage>251</epage><pages>237-251</pages><issn>0165-0378</issn><eissn>1872-7603</eissn><coden>JRIMDR</coden><abstract>The ability of fetal and neonatal F1 thymocytes to regulate parental graft versus host (GvH) reactions against self histocompatibility antigens was investigated. The results obtained showed that: (1) fetal F1 thymocytes were able to suppress both maternal and paternal GvH reactivity; (2) at birth, thymocytes were still able to suppress maternal GvH reactivity while no suppression of paternal reactions was detected; the ability to suppress maternal GvH reactions could be detected until day 3; (3) the loss of suppressor activity correlated with the ability of thymocytes to contrasuppress parental GvH reactions. Thus, 24-h F1 thymocytes showed contrasuppressor activity on paternal GvH reactivity and 4-day thymocytes on maternal reactivity. Thymic cells with contrasuppressor activity were shown to be Lyt-1
+, CD4
+, CD8
− and adherent to
Vicia villosa. These results suggest the existence of parental effects influencing the duration of thymic suppression and the subsequent appearance of contrasuppressor activity on GvH reactions against self histocompatibility antigens, according to the maternal or paternal origin of self antigens towards which the reaction is directed.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>1960705</pmid><doi>10.1016/0165-0378(91)90049-V</doi><tpages>15</tpages></addata></record> |
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| subjects | Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Animals, Newborn - immunology Autoantigens - immunology Biological and medical sciences CD4 Antigens CD8 Antigens Crosses, Genetic Female Graft vs Host Reaction - genetics Graft vs Host Reaction - immunology Histocompatibility Antigens - genetics Histocompatibility Antigens - immunology Intensive care medicine Lectins - immunology Lymph Nodes - immunology Medical sciences Mice Mice, Inbred Strains Plant Lectins Pregnancy Receptors, Mitogen - immunology Suppressor Factors, Immunologic - immunology Thymus Gland - immunology Thymus Gland - transplantation |
| title | Neonatal thymic contrasuppressor activity on graft versus host reactions towards self histocompatibility antigens. Parental effects |
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