Low-Pressure-Sensitive Baroreceptor Fibers Recorded From Rabbit Carotid Sinus Nerves
Activity was recorded from physiologically identified baroreceptor or chemoreceptor fibers in carotid sinus nerves of urethane-anesthetized spontaneously breathing rabbits. A carotid sinus area was vascularly isolated so that carotid sinus pressure and perfusion medium (Lockeʼs solution or rabbit bl...
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| Veröffentlicht in: | Circulation research 1991-12, Vol.69 (6), p.1608-1615 |
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| creator | Qu, Long Stuesse, Sherry L |
| description | Activity was recorded from physiologically identified baroreceptor or chemoreceptor fibers in carotid sinus nerves of urethane-anesthetized spontaneously breathing rabbits. A carotid sinus area was vascularly isolated so that carotid sinus pressure and perfusion medium (Lockeʼs solution or rabbit blood) could be controlled. The cervical sympathetic, vagus, and aortic depressor nerves were bilaterally cut to eliminate vagal and cardiopulmonary reflexes. Baroreceptor fibers could be divided into two groupsfibers with a mean firing threshold of 47.6±1.9 mm Hg and no activity below this threshold (37 fibers) and fibers that were active at low intrasinus pressures (18.1±2.2 impulses/sec at an intrasinus pressure of 0 mm Hg). The baroreceptor fibers that were spontaneously active at low pressures were also chemically sensitivedischarge rate was increased by 5-hydroxytryptamine (10 fibers, p |
| doi_str_mv | 10.1161/01.RES.69.6.1608 |
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A carotid sinus area was vascularly isolated so that carotid sinus pressure and perfusion medium (Lockeʼs solution or rabbit blood) could be controlled. The cervical sympathetic, vagus, and aortic depressor nerves were bilaterally cut to eliminate vagal and cardiopulmonary reflexes. Baroreceptor fibers could be divided into two groupsfibers with a mean firing threshold of 47.6±1.9 mm Hg and no activity below this threshold (37 fibers) and fibers that were active at low intrasinus pressures (18.1±2.2 impulses/sec at an intrasinus pressure of 0 mm Hg). The baroreceptor fibers that were spontaneously active at low pressures were also chemically sensitivedischarge rate was increased by 5-hydroxytryptamine (10 fibers, p<0.01), nicotine (10 fibers, p<0.01), or hypercapnia (13 fibers, p<0.001). The activity of baroreceptor fibers with a clear pressure threshold was usually decreased by hypercapnia (26 of 27 fibers, from 18.8±3.1 to 13.2±3.9 impulses/sec). Chemoreceptor fibers failed to respond to intrasinus pressure changes from 0 to 100 mm Hg (n=25 fibers, p>0.5) but were sensitive to chemical changes, as expected. Thus, there is a subset of baroreceptor fibers that, under certain conditions, is spontaneously active at very low intrasinus pressures and responds to changes in the chemical milieu.</description><identifier>ISSN: 0009-7330</identifier><identifier>EISSN: 1524-4571</identifier><identifier>DOI: 10.1161/01.RES.69.6.1608</identifier><identifier>PMID: 1954680</identifier><identifier>CODEN: CIRUAL</identifier><language>eng</language><publisher>Hagerstown, MD: American Heart Association, Inc</publisher><subject>Action Potentials ; Animals ; Biological and medical sciences ; Blood Pressure ; Blood vessels and receptors ; Carotid Sinus - physiology ; Fundamental and applied biological sciences. Psychology ; Hypercapnia - physiopathology ; Hypoxia - physiopathology ; Pressoreceptors - physiology ; Rabbits ; Sympathetic Nervous System - physiology ; Vertebrates: cardiovascular system</subject><ispartof>Circulation research, 1991-12, Vol.69 (6), p.1608-1615</ispartof><rights>1991 American Heart Association, Inc.</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4479-26a31e562b28bd23a895d93904e30fa7678cee6516ac29f433b64a70c58e35c53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5074372$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1954680$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Qu, Long</creatorcontrib><creatorcontrib>Stuesse, Sherry L</creatorcontrib><title>Low-Pressure-Sensitive Baroreceptor Fibers Recorded From Rabbit Carotid Sinus Nerves</title><title>Circulation research</title><addtitle>Circ Res</addtitle><description>Activity was recorded from physiologically identified baroreceptor or chemoreceptor fibers in carotid sinus nerves of urethane-anesthetized spontaneously breathing rabbits. A carotid sinus area was vascularly isolated so that carotid sinus pressure and perfusion medium (Lockeʼs solution or rabbit blood) could be controlled. The cervical sympathetic, vagus, and aortic depressor nerves were bilaterally cut to eliminate vagal and cardiopulmonary reflexes. Baroreceptor fibers could be divided into two groupsfibers with a mean firing threshold of 47.6±1.9 mm Hg and no activity below this threshold (37 fibers) and fibers that were active at low intrasinus pressures (18.1±2.2 impulses/sec at an intrasinus pressure of 0 mm Hg). The baroreceptor fibers that were spontaneously active at low pressures were also chemically sensitivedischarge rate was increased by 5-hydroxytryptamine (10 fibers, p<0.01), nicotine (10 fibers, p<0.01), or hypercapnia (13 fibers, p<0.001). The activity of baroreceptor fibers with a clear pressure threshold was usually decreased by hypercapnia (26 of 27 fibers, from 18.8±3.1 to 13.2±3.9 impulses/sec). Chemoreceptor fibers failed to respond to intrasinus pressure changes from 0 to 100 mm Hg (n=25 fibers, p>0.5) but were sensitive to chemical changes, as expected. Thus, there is a subset of baroreceptor fibers that, under certain conditions, is spontaneously active at very low intrasinus pressures and responds to changes in the chemical milieu.</description><subject>Action Potentials</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Blood vessels and receptors</subject><subject>Carotid Sinus - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypercapnia - physiopathology</subject><subject>Hypoxia - physiopathology</subject><subject>Pressoreceptors - physiology</subject><subject>Rabbits</subject><subject>Sympathetic Nervous System - physiology</subject><subject>Vertebrates: cardiovascular system</subject><issn>0009-7330</issn><issn>1524-4571</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU1v00AQhlcIVNLCnQuSD4ibzcx-eo8QNS1SRKuknFfr9Vg1OHHYtRvx77tVIjiMRqN53jk8w9gHhApR4xfAanO9rbStdIUa6ldsgYrLUiqDr9kCAGxphIC37DKlXwAoBbcX7AKtkrqGBXtYj8fyPlJKc6RyS_vUT_0TFd98HCMFOkxjLFZ9QzEVGwpjbKktVnHcFRvfNP1ULDM49W2x7fdzKn5QfKL0jr3p_JDo_blfsZ-r64flbbm-u_m-_Loug5TGllx7gaQ0b3jdtFz42qrWCguSBHTeaFMHIq1Q-8BtJ4VotPQGgqpJqKDEFft8unuI45-Z0uR2fQo0DH5P45yc4QoElyaDcAJDHFOK1LlD7Hc-_nUI7kWkA3RZpNPWafciMkc-nm_PzY7a_4GTubz_dN77FPzQRb8PffqHKTBSGJ4xecKO4zBlib-H-UjRPZIfpkeX_wMCkJdoLSLPU5kLrXgGNCOJ0w</recordid><startdate>199112</startdate><enddate>199112</enddate><creator>Qu, Long</creator><creator>Stuesse, Sherry L</creator><general>American Heart Association, Inc</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199112</creationdate><title>Low-Pressure-Sensitive Baroreceptor Fibers Recorded From Rabbit Carotid Sinus Nerves</title><author>Qu, Long ; Stuesse, Sherry L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4479-26a31e562b28bd23a895d93904e30fa7678cee6516ac29f433b64a70c58e35c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Action Potentials</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Blood vessels and receptors</topic><topic>Carotid Sinus - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypercapnia - physiopathology</topic><topic>Hypoxia - physiopathology</topic><topic>Pressoreceptors - physiology</topic><topic>Rabbits</topic><topic>Sympathetic Nervous System - physiology</topic><topic>Vertebrates: cardiovascular system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Qu, Long</creatorcontrib><creatorcontrib>Stuesse, Sherry L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Qu, Long</au><au>Stuesse, Sherry L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Low-Pressure-Sensitive Baroreceptor Fibers Recorded From Rabbit Carotid Sinus Nerves</atitle><jtitle>Circulation research</jtitle><addtitle>Circ Res</addtitle><date>1991-12</date><risdate>1991</risdate><volume>69</volume><issue>6</issue><spage>1608</spage><epage>1615</epage><pages>1608-1615</pages><issn>0009-7330</issn><eissn>1524-4571</eissn><coden>CIRUAL</coden><abstract>Activity was recorded from physiologically identified baroreceptor or chemoreceptor fibers in carotid sinus nerves of urethane-anesthetized spontaneously breathing rabbits. A carotid sinus area was vascularly isolated so that carotid sinus pressure and perfusion medium (Lockeʼs solution or rabbit blood) could be controlled. The cervical sympathetic, vagus, and aortic depressor nerves were bilaterally cut to eliminate vagal and cardiopulmonary reflexes. Baroreceptor fibers could be divided into two groupsfibers with a mean firing threshold of 47.6±1.9 mm Hg and no activity below this threshold (37 fibers) and fibers that were active at low intrasinus pressures (18.1±2.2 impulses/sec at an intrasinus pressure of 0 mm Hg). The baroreceptor fibers that were spontaneously active at low pressures were also chemically sensitivedischarge rate was increased by 5-hydroxytryptamine (10 fibers, p<0.01), nicotine (10 fibers, p<0.01), or hypercapnia (13 fibers, p<0.001). The activity of baroreceptor fibers with a clear pressure threshold was usually decreased by hypercapnia (26 of 27 fibers, from 18.8±3.1 to 13.2±3.9 impulses/sec). Chemoreceptor fibers failed to respond to intrasinus pressure changes from 0 to 100 mm Hg (n=25 fibers, p>0.5) but were sensitive to chemical changes, as expected. Thus, there is a subset of baroreceptor fibers that, under certain conditions, is spontaneously active at very low intrasinus pressures and responds to changes in the chemical milieu.</abstract><cop>Hagerstown, MD</cop><pub>American Heart Association, Inc</pub><pmid>1954680</pmid><doi>10.1161/01.RES.69.6.1608</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Circulation research, 1991-12, Vol.69 (6), p.1608-1615 |
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| language | eng |
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| source | MEDLINE; EZB Electronic Journals Library; American Heart Association; Journals@Ovid Complete |
| subjects | Action Potentials Animals Biological and medical sciences Blood Pressure Blood vessels and receptors Carotid Sinus - physiology Fundamental and applied biological sciences. Psychology Hypercapnia - physiopathology Hypoxia - physiopathology Pressoreceptors - physiology Rabbits Sympathetic Nervous System - physiology Vertebrates: cardiovascular system |
| title | Low-Pressure-Sensitive Baroreceptor Fibers Recorded From Rabbit Carotid Sinus Nerves |
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