Translin binds to the sequences adjacent to the breakpoints of the TLS and CHOP genes in liposarcomas with translocation t(12;16)

Myxoid and round-cell liposarcomas share the translocation t(12;16)(q13;p11) creating the TLS-CHOP fusion gene as a common genetic alteration. We previously reported several unique characteristics of genomic sequences around the breakpoints in the TLS and CHOP loci, and among them was the presence o...

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Veröffentlicht in:	Oncogene 2000-11, Vol.19 (50), p.5821-5825
Hauptverfasser:	HOSAKA, Taisuke, KANOE, Hiroshi, NAKAMURA, Takashi, TOGUCHIDA, Junya, NAKAYAMA, Tomitaka, MURAKAMI, Hiroshi, YAMAMOTO, Hiroshi, NAKAMATA, Takeharu, TSUBOYAMA, Tadao, OKA, Masanori, KASAI, Masataka, SASAKI, Masao S
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Biological and medical sciences Bone surgery Breakpoints CCAAT-Enhancer-Binding Proteins - genetics Cell interactions, adhesion CHOP gene chromosome 12 chromosome 16 Chromosome Breakage Chromosome translocations Chromosomes Chromosomes, Human, Pair 12 Chromosomes, Human, Pair 16 Consensus Sequence DNA binding proteins DNA, Neoplasm - genetics DNA, Neoplasm - metabolism DNA-Binding Proteins - metabolism Electrophoretic mobility fibrosarcoma Fundamental and applied biological sciences. Psychology Fusion protein Genes Genetic aspects HeLa Cells Humans Leukemia liposarcoma Liposarcoma, Myxoid - genetics Liposarcoma, Myxoid - metabolism Molecular and cellular biology Oligonucleotides Oligonucleotides - genetics Oligonucleotides - metabolism Oncogene Proteins, Fusion - genetics Orthopedics Physiological aspects Proteins Risk factors RNA-Binding Protein FUS Sarcoma Substrate Specificity TLS gene Transcription Factor CHOP translin Translocation (Genetics) Translocation, Genetic TSN protein Tumors
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