CORONARY VASCULAR RESPONSE TO ENDOTHELIN IN ISOLATED PERFUSED HEARTS OF SPONTANEOUSLY HYPERTENSIVE RATS

SUMMARY 1. The coronary vasoconstrictive response to endothelin (ET‐1) was evaluated using the isolated perfused hearts of 15 week old spontaneously hypertensive rats (SHR) and age‐matched Wistar‐Kyoto rats (WKY). Endothelin produced marked increases in perfusion pressure (PP) in both SHR and WKY. T...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 1991-09, Vol.18 (9), p.661-669
Hauptverfasser:	Takeshita, Hiroshi, Nishikibe, Masaru, Yano, Mitsuo, Ikemoto, Fumihiko
Format:	Artikel
Sprache:	eng
Schlagworte:	3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester angiotensin-converting enzyme Angiotensin-Converting Enzyme Inhibitors - pharmacology Animals Biological and medical sciences Blood Pressure Cardiovascular system Coronary Circulation - drug effects Coronary Vessels - drug effects endothelin-1 Endothelins - pharmacology heart Heart - drug effects Hypertension - physiopathology hypertrophy Male Medical sciences Miscellaneous Pharmacology. Drug treatments Rats Rats, Inbred SHR Rats, Inbred WKY spontaneously hypertensive rats Vasoconstriction - drug effects Vasoconstrictor Agents - pharmacology Wistar-Kyoto rats
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