Sustained delivery and expression of DNA encapsulated in polymeric nanoparticles

Sustained release polymeric gene delivery systems offer increased resistance to nuclease degradation, increased amounts of plasmid DNA (pDNA) uptake, and the possibility of control in dosing and sustained duration of pDNA administration. Furthermore, such a system lacks the inherent problems associa...

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Veröffentlicht in:	Gene therapy 2000-11, Vol.7 (22), p.1896-1905
Hauptverfasser:	COHEN, H, LEVY, R. J, GAO, J, FISHBEIN, I, KOUSAEV, V, SOSNOWSKI, S, SLOMKOWSKI, S, GOLOMB, G
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Alkaline phosphatase Alkaline Phosphatase - genetics Animals Biodegradability Biological and medical sciences Biotechnology Cations Cell Line Controlled release Deoxyribonucleic acid DNA Endothelium Fibroblasts Fundamental and applied biological sciences. Psychology Gene Expression Gene therapy Gene transfer Genetic Vectors - administration & dosage Health. Pharmaceutical industry Humans Industrial applications and implications. Economical aspects Injections, Intramuscular Lactic Acid Liposomes Mice Microspheres Nanoparticles Nuclease Placenta - enzymology Plasmids poly(DL-lactide-co-glycolide) Polyglycolic Acid polylactide-co-glycolide Polymers Reporter gene Structure-function relationships Time Factors Transfection Transfection - methods
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