PATHOGENETIC ROLE OF VASCULAR ANGIOTENSIN-CONVERTING ENZYME IN THE SPONTANEOUSLY HYPERTENSIVE RAT

SUMMARY 1. This study was undertaken to examine the possibility that the level of angiotensin‐converting enzyme (ACE) increases in vascular tissue, and that this may participate in the pathogenesis of hypertension in spontaneously hypertensive rat (SHR). 2. In SHR, at the established hypertensive st...

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Veröffentlicht in:	Clinical and experimental pharmacology & physiology 1991-09, Vol.18 (9), p.649-659
Hauptverfasser:	Okunishi, H., Kawamoto, T., Kurobe, Y., Oka, Y., Ishii, K., Tanaka, T., Miyazaki, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	aging Aging - physiology Angiotensin-Converting Enzyme Inhibitors - therapeutic use Animals aorta Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Blood Vessels - metabolism Cardiology. Vascular system circulatory renin-angiotensin system Enalapril - analogs & derivatives Enalapril - therapeutic use Experimental diseases Heart Rate Hypertension - etiology hypertension development hypertension maintenance Lisinopril Male Medical sciences Peptidyl-Dipeptidase A - blood Peptidyl-Dipeptidase A - metabolism Peptidyl-Dipeptidase A - physiology Rats Rats, Inbred SHR Rats, Inbred WKY spirapril tissue renin-angiotensin system
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