A precise group size in Dictyostelium is generated by a cell-counting factor modulating cell-cell adhesion

A remarkable aspect of Dictyostelium development is that cells form evenly sized groups of approximately 2 x 10(4) cells. A secreted 450 kDa protein complex called counting factor (CF) regulates the number of cells per group. We find that CF regulates group size by repressing cell-cell adhesion. In...

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Veröffentlicht in:	Molecular cell 2000-10, Vol.6 (4), p.953-959
Hauptverfasser:	Roisin-Bouffay, C, Jang, W, Caprette, D R, Gomer, R H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Adhesion - physiology Computer Simulation counting factor Dictyostelium Dictyostelium - genetics Dictyostelium - growth & development Dictyostelium - physiology Movement Protozoan Proteins - physiology
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