DYNEMICINS O, P AND Q: NOVEL ANTIBIOTICS RELATED TO DYNEMICIN A: ISOLATION, CHARACTERIZATION AND BIOLOGICAL ACTIVITY
New antibiotics, dynemicins O (3), P (4) and Q (5), were isolated from the culture broth of Micromonospora chersina M956-1, the dynemicin A (1)-producing strain. An ethyl acetate extract of a tank culture was roughly separated by a column of Diaion SP-800 and was further purified by combining a vari...
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| Veröffentlicht in: | Journal of antibiotics 1991/10/25, Vol.44(10), pp.1037-1044 |
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| container_end_page | 1044 |
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| container_issue | 10 |
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| container_title | Journal of antibiotics |
| container_volume | 44 |
| creator | MIYOSHI-SAITOH, MEGUMI MORISAKI, NAOKO TOKIWA, YOSHIYUKI IWASAKI, SHIGEO KONISHI, MASATAKA SAITOH, KYOICHIRO OKI, TOSHIKAZU |
| description | New antibiotics, dynemicins O (3), P (4) and Q (5), were isolated from the culture broth of Micromonospora chersina M956-1, the dynemicin A (1)-producing strain. An ethyl acetate extract of a tank culture was roughly separated by a column of Diaion SP-800 and was further purified by combining a variety of column chromatographies to afford a few mg of compounds 3, 4 and 5. Their structures, analyzed from the spectral data, had a bridging phenylene group, a vic-diol and an oxo group in place of the respective 1, 5-diyn-3-ene bridge, the epoxide ring and the carboxyl group in dynemicin A. Their biological activities were evaluated against bacteria and tumor cells. |
| doi_str_mv | 10.7164/antibiotics.44.1037 |
| format | Article |
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An ethyl acetate extract of a tank culture was roughly separated by a column of Diaion SP-800 and was further purified by combining a variety of column chromatographies to afford a few mg of compounds 3, 4 and 5. Their structures, analyzed from the spectral data, had a bridging phenylene group, a vic-diol and an oxo group in place of the respective 1, 5-diyn-3-ene bridge, the epoxide ring and the carboxyl group in dynemicin A. Their biological activities were evaluated against bacteria and tumor cells.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.44.1037</identifier><identifier>PMID: 1955384</identifier><identifier>CODEN: JANTAJ</identifier><language>eng</language><publisher>Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Alkenes ; Animals ; Anthraquinones - chemistry ; Anthraquinones - isolation & purification ; Anthraquinones - pharmacology ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - isolation & purification ; Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; Antibiotics, Antineoplastic - chemistry ; Antibiotics, Antineoplastic - isolation & purification ; Antibiotics, Antineoplastic - pharmacology ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Bacteria - drug effects ; Biological and medical sciences ; Chromatography ; Drug Screening Assays, Antitumor ; Enediynes ; Humans ; Magnetic Resonance Spectroscopy ; Medical sciences ; Mice ; Microbial Sensitivity Tests ; Micromonospora - metabolism ; Pharmacology. Drug treatments ; Spectrum Analysis ; Tumor Cells, Cultured - drug effects</subject><ispartof>The Journal of Antibiotics, 1991/10/25, Vol.44(10), pp.1037-1044</ispartof><rights>Japan Antibiotics Research Association</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5014806$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1955384$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MIYOSHI-SAITOH, MEGUMI</creatorcontrib><creatorcontrib>MORISAKI, NAOKO</creatorcontrib><creatorcontrib>TOKIWA, YOSHIYUKI</creatorcontrib><creatorcontrib>IWASAKI, SHIGEO</creatorcontrib><creatorcontrib>KONISHI, MASATAKA</creatorcontrib><creatorcontrib>SAITOH, KYOICHIRO</creatorcontrib><creatorcontrib>OKI, TOSHIKAZU</creatorcontrib><title>DYNEMICINS O, P AND Q: NOVEL ANTIBIOTICS RELATED TO DYNEMICIN A: ISOLATION, CHARACTERIZATION AND BIOLOGICAL ACTIVITY</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>New antibiotics, dynemicins O (3), P (4) and Q (5), were isolated from the culture broth of Micromonospora chersina M956-1, the dynemicin A (1)-producing strain. An ethyl acetate extract of a tank culture was roughly separated by a column of Diaion SP-800 and was further purified by combining a variety of column chromatographies to afford a few mg of compounds 3, 4 and 5. Their structures, analyzed from the spectral data, had a bridging phenylene group, a vic-diol and an oxo group in place of the respective 1, 5-diyn-3-ene bridge, the epoxide ring and the carboxyl group in dynemicin A. Their biological activities were evaluated against bacteria and tumor cells.</description><subject>Alkenes</subject><subject>Animals</subject><subject>Anthraquinones - chemistry</subject><subject>Anthraquinones - isolation & purification</subject><subject>Anthraquinones - pharmacology</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - isolation & purification</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Antibiotics, Antineoplastic - chemistry</subject><subject>Antibiotics, Antineoplastic - isolation & purification</subject><subject>Antibiotics, Antineoplastic - pharmacology</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacteria - drug effects</subject><subject>Biological and medical sciences</subject><subject>Chromatography</subject><subject>Drug Screening Assays, Antitumor</subject><subject>Enediynes</subject><subject>Humans</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Microbial Sensitivity Tests</subject><subject>Micromonospora - metabolism</subject><subject>Pharmacology. Drug treatments</subject><subject>Spectrum Analysis</subject><subject>Tumor Cells, Cultured - drug effects</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkUFPhDAQhRujWdfVX2BMejCeZG1pS4sXgywqCYK6aOKJlFKUDcuulD3478VIiJeZTN43k7w3AJxiNOfYoVey6aq82nSVMnNK5xgRvgemWAhsYeq4-2CKkI0tIWx0CI6MWaGeIFxMwAS7jBFBp-Bm8R4Hj6EfxkuYXMIn6MUL-HwN4-QtiPohDW_DJA39JXwJIi8NFjBN4LgDvWNwUMra6JOhz8DrXZD6D1aU3Ie-F1kr28adhXPEBcdSKGYrljNBGSeK8cItucy5y3nJGeWYoKKQmhS6LF2bF5jllEhFcjIDF393t-3ma6dNl60ro3Rdy0ZvdibjNnUJEnYPng3gLl_rItu21Vq239nguNfPB10aJeuylY2qzIgxhKlATo_Ff9jKdPJDj7ps-7hrnf3LHruOyCjNMBrq7yNGUH3KNtMN-QGl9Xus</recordid><startdate>199110</startdate><enddate>199110</enddate><creator>MIYOSHI-SAITOH, MEGUMI</creator><creator>MORISAKI, NAOKO</creator><creator>TOKIWA, YOSHIYUKI</creator><creator>IWASAKI, SHIGEO</creator><creator>KONISHI, MASATAKA</creator><creator>SAITOH, KYOICHIRO</creator><creator>OKI, TOSHIKAZU</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><general>Japan Antibiotics Research Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>199110</creationdate><title>DYNEMICINS O, P AND Q: NOVEL ANTIBIOTICS RELATED TO DYNEMICIN A</title><author>MIYOSHI-SAITOH, MEGUMI ; MORISAKI, NAOKO ; TOKIWA, YOSHIYUKI ; IWASAKI, SHIGEO ; KONISHI, MASATAKA ; SAITOH, KYOICHIRO ; OKI, TOSHIKAZU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j221t-1b07871a8c52c5b584573c57d9f7ab7977f7547130ddae3deff927d15b43ac3b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Alkenes</topic><topic>Animals</topic><topic>Anthraquinones - chemistry</topic><topic>Anthraquinones - isolation & purification</topic><topic>Anthraquinones - pharmacology</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - isolation & purification</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antibacterial agents</topic><topic>Antibiotics, Antineoplastic - chemistry</topic><topic>Antibiotics, Antineoplastic - isolation & purification</topic><topic>Antibiotics, Antineoplastic - pharmacology</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Bacteria - drug effects</topic><topic>Biological and medical sciences</topic><topic>Chromatography</topic><topic>Drug Screening Assays, Antitumor</topic><topic>Enediynes</topic><topic>Humans</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Microbial Sensitivity Tests</topic><topic>Micromonospora - metabolism</topic><topic>Pharmacology. 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Antibiot.</addtitle><date>1991-10</date><risdate>1991</risdate><volume>44</volume><issue>10</issue><spage>1037</spage><epage>1044</epage><pages>1037-1044</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><coden>JANTAJ</coden><abstract>New antibiotics, dynemicins O (3), P (4) and Q (5), were isolated from the culture broth of Micromonospora chersina M956-1, the dynemicin A (1)-producing strain. An ethyl acetate extract of a tank culture was roughly separated by a column of Diaion SP-800 and was further purified by combining a variety of column chromatographies to afford a few mg of compounds 3, 4 and 5. Their structures, analyzed from the spectral data, had a bridging phenylene group, a vic-diol and an oxo group in place of the respective 1, 5-diyn-3-ene bridge, the epoxide ring and the carboxyl group in dynemicin A. 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| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1991/10/25, Vol.44(10), pp.1037-1044 |
| issn | 0021-8820 1881-1469 |
| language | eng |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Alkenes Animals Anthraquinones - chemistry Anthraquinones - isolation & purification Anthraquinones - pharmacology Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - isolation & purification Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics, Antineoplastic - chemistry Antibiotics, Antineoplastic - isolation & purification Antibiotics, Antineoplastic - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteria - drug effects Biological and medical sciences Chromatography Drug Screening Assays, Antitumor Enediynes Humans Magnetic Resonance Spectroscopy Medical sciences Mice Microbial Sensitivity Tests Micromonospora - metabolism Pharmacology. Drug treatments Spectrum Analysis Tumor Cells, Cultured - drug effects |
| title | DYNEMICINS O, P AND Q: NOVEL ANTIBIOTICS RELATED TO DYNEMICIN A: ISOLATION, CHARACTERIZATION AND BIOLOGICAL ACTIVITY |
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