Naive CD4+ T lymphocytes express high levels of Bcl-2 after highly active antiretroviral therapy for HIV infection

The mechanism causing the increasing number of peripheral T cells after highly active antiretroviral therapy (HAART) is still unclear. The bcl-2 oncogene prevents spontaneous apoptosis (SA) in lymphocytes. Spontaneous apoptosis could be a determinant of HIV immunodeficiency and can be reversed by HA...

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Veröffentlicht in:	AIDS research and human retroviruses 2000-11, Vol.16 (17), p.1805-1807
Hauptverfasser:	AIRO, Paolo, TORTI, Carlo, UCCELLI, Maria Cristina, MALACARNE, Fabio, PALVARINI, Loredana, CAROSI, Giampiero, CASTELLI, Francesco
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged AIDS/HIV Anti-HIV Agents - therapeutic use Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral Therapy, Highly Active Antiviral agents Biological and medical sciences CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - metabolism Female Fundamental and applied biological sciences. Psychology HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV-1 - physiology Human viral diseases Humans Infectious diseases Male Medical sciences Microbiology Middle Aged Pharmacology. Drug treatments Proto-Oncogene Proteins c-bcl-2 - metabolism Reverse Transcriptase Inhibitors - therapeutic use Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load
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