Pharmacokinetic/Pharmacodynamic Modeling in Drug Research and Development

The two domains in clinical pharmacology dealing with optimizing dosing recommendations are pharmacokinetics and pharmacodynamics. However, the usefulness of these disciplines is limited if viewed in isolation. Pharmacokinetic/pharmacodynamic (PK/PD) relationships and modeling builds the bridge betw...

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Veröffentlicht in:	Journal of clinical pharmacology 2000-12, Vol.40 (12), p.1399-1418
Hauptverfasser:	Derendorf, Hartmut, Lesko, Lawrence J., Chaikin, Philip, Colburn, Wayne A., Lee, Peter, Miller, Raymond, Powell, Robert, Rhodes, Gerald, Stanski, Donald, Venitz, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Drug Design Drug Therapy General pharmacology Humans Medical sciences Models, Biological Pharmacokinetics Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions Pharmacology, Clinical Pharmacology. Drug treatments Protein Binding Survival Rate Time Factors Treatment Outcome
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