Early loss of synaptic protein PSD-95 from rod terminals of rhodopsin P347L transgenic porcine retina

Retinitis pigmentosa (RP), a type of retinal degeneration involving first rod and then slow cone photoreceptor degeneration, can be caused by any of a number of mutations in different genes. In the cases of mutations affecting rod-specific genes such as rhodopsin, it is unclear how the mutations may...

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Veröffentlicht in:	Brain research 2000-12, Vol.885 (1), p.53-61
Hauptverfasser:	Blackmon, Scott M, Peng, You-Wei, Hao, Ying, Moon, Suk Jin, Oliveira, Leonardo B, Tatebayashi, Misako, Petters, Robert M, Wong, Fulton
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Animals, Newborn Antibodies Biological and medical sciences Disease Models, Animal Medical sciences Nerve Tissue Proteins - analysis Nerve Tissue Proteins - immunology Nerve Tissue Proteins - metabolism Ophthalmology postsynaptic density 95 protein PSD-95 Retinal degeneration Retinal Rod Photoreceptor Cells - chemistry Retinal Rod Photoreceptor Cells - metabolism Retinal Rod Photoreceptor Cells - pathology Retinitis pigmentosa Retinitis Pigmentosa - genetics Retinitis Pigmentosa - metabolism Retinitis Pigmentosa - pathology Retinopathies Rhodopsin - genetics Swine Synapses - chemistry Synapses - metabolism
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