Alternative transcripts of the rat and human dopamine D3 receptor
A cDNA for the rat dopamine D3 receptor containing a 113 bp deletion has been isolated. The segment deleted, encompassing the first extracellular loop and third transmembrane domain, alters the reading frame, introducing 19 amino acids not found in the full length receptor followed by a premature st...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1991-10, Vol.180 (2), p.1031-1035 |
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| container_issue | 2 |
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| container_title | Biochemical and biophysical research communications |
| container_volume | 180 |
| creator | Snyder, Lenore A. Roberts, James L. Sealfon, Stuart C. |
| description | A cDNA for the rat dopamine D3 receptor containing a 113 bp deletion has been isolated. The segment deleted, encompassing the first extracellular loop and third transmembrane domain, alters the reading frame, introducing 19 amino acids not found in the full length receptor followed by a premature stop codon. This novel mRNA encodes a 109 amino acid protein containing two putative tranmembrane domains. A similar variant cDNA for the human D3 receptor has also been identified. |
| doi_str_mv | 10.1016/S0006-291X(05)81169-6 |
| format | Article |
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The segment deleted, encompassing the first extracellular loop and third transmembrane domain, alters the reading frame, introducing 19 amino acids not found in the full length receptor followed by a premature stop codon. This novel mRNA encodes a 109 amino acid protein containing two putative tranmembrane domains. A similar variant cDNA for the human D3 receptor has also been identified.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Cell receptors</subject><subject>Cell structures and functions</subject><subject>Chromosome Deletion</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>Humans</topic><topic>Molecular and cellular biology</topic><topic>Molecular Sequence Data</topic><topic>Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine)</topic><topic>Oligodeoxyribonucleotides</topic><topic>Polymerase Chain Reaction</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Dopamine - genetics</topic><topic>Receptors, Dopamine D2</topic><topic>Receptors, Dopamine D3</topic><topic>Restriction Mapping</topic><topic>RNA Splicing</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - isolation & purification</topic><topic>Sequence Homology, Nucleic Acid</topic><topic>Transcription, Genetic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Snyder, Lenore A.</creatorcontrib><creatorcontrib>Roberts, James L.</creatorcontrib><creatorcontrib>Sealfon, Stuart C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Snyder, Lenore A.</au><au>Roberts, James L.</au><au>Sealfon, Stuart C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alternative transcripts of the rat and human dopamine D3 receptor</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1991-10-31</date><risdate>1991</risdate><volume>180</volume><issue>2</issue><spage>1031</spage><epage>1035</epage><pages>1031-1035</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><coden>BBRCA9</coden><abstract>A cDNA for the rat dopamine D3 receptor containing a 113 bp deletion has been isolated. The segment deleted, encompassing the first extracellular loop and third transmembrane domain, alters the reading frame, introducing 19 amino acids not found in the full length receptor followed by a premature stop codon. This novel mRNA encodes a 109 amino acid protein containing two putative tranmembrane domains. A similar variant cDNA for the human D3 receptor has also been identified.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>1953708</pmid><doi>10.1016/S0006-291X(05)81169-6</doi><tpages>5</tpages></addata></record> |
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| ispartof | Biochemical and biophysical research communications, 1991-10, Vol.180 (2), p.1031-1035 |
| issn | 0006-291X 1090-2104 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Amino Acid Sequence Animals Base Sequence Biological and medical sciences Brain - metabolism Cell receptors Cell structures and functions Chromosome Deletion Fundamental and applied biological sciences. Psychology Humans Molecular and cellular biology Molecular Sequence Data Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) Oligodeoxyribonucleotides Polymerase Chain Reaction Rats Rats, Inbred Strains Receptors, Dopamine - genetics Receptors, Dopamine D2 Receptors, Dopamine D3 Restriction Mapping RNA Splicing RNA, Messenger - genetics RNA, Messenger - isolation & purification Sequence Homology, Nucleic Acid Transcription, Genetic |
| title | Alternative transcripts of the rat and human dopamine D3 receptor |
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