Alternative transcripts of the rat and human dopamine D3 receptor

A cDNA for the rat dopamine D3 receptor containing a 113 bp deletion has been isolated. The segment deleted, encompassing the first extracellular loop and third transmembrane domain, alters the reading frame, introducing 19 amino acids not found in the full length receptor followed by a premature st...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biochemical and biophysical research communications 1991-10, Vol.180 (2), p.1031-1035
Hauptverfasser:	Snyder, Lenore A., Roberts, James L., Sealfon, Stuart C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Sequence Biological and medical sciences Brain - metabolism Cell receptors Cell structures and functions Chromosome Deletion Fundamental and applied biological sciences. Psychology Humans Molecular and cellular biology Molecular Sequence Data Monoamines receptors (catecholamine, serotonine, histamine, acetylcholine) Oligodeoxyribonucleotides Polymerase Chain Reaction Rats Rats, Inbred Strains Receptors, Dopamine - genetics Receptors, Dopamine D2 Receptors, Dopamine D3 Restriction Mapping RNA Splicing RNA, Messenger - genetics RNA, Messenger - isolation & purification Sequence Homology, Nucleic Acid Transcription, Genetic
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A cDNA for the rat dopamine D3 receptor containing a 113 bp deletion has been isolated. The segment deleted, encompassing the first extracellular loop and third transmembrane domain, alters the reading frame, introducing 19 amino acids not found in the full length receptor followed by a premature stop codon. This novel mRNA encodes a 109 amino acid protein containing two putative tranmembrane domains. A similar variant cDNA for the human D3 receptor has also been identified.
ISSN:	0006-291X 1090-2104
DOI:	10.1016/S0006-291X(05)81169-6