The Th1-Th2 classification of cellular immune responses: concepts, current thinking and applications in haematological malignancy
The finding that T cell immune responses could be divided into those promoting cell mediated immunity (Th1) and humoral responses (Th2) has had a profound effect on the understanding of immune response generation over the last 15 years. With ever increasing knowledge of the immune system, the model...
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| Veröffentlicht in: | Blood reviews 2000-12, Vol.14 (4), p.228-239 |
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| container_title | Blood reviews |
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| creator | Lappin, M.B. Campbell, J.D.M. |
| description | The finding that T cell immune responses could be divided into those promoting cell mediated immunity (Th1) and humoral responses (Th2) has had a profound effect on the understanding of immune response generation over the last 15 years. With ever increasing knowledge of the immune system, the model has come under criticism, as not all responses easily fit the classification. Nonetheless, the model still provides a valuable framework on which to base immunological research. In this review we update the model with current thinking regarding the generation and maintenance of immune responses. We then examine how the Th1–Th2 paradigm may be applied in developing new understanding of several topical issues in haematological malignancy—control of graft-versus–host disease; cytokine control of proliferating clones in B and T cell diseases; and suppression of T cell responses in multiple myeloma. |
| doi_str_mv | 10.1054/blre.2000.0136 |
| format | Article |
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With ever increasing knowledge of the immune system, the model has come under criticism, as not all responses easily fit the classification. Nonetheless, the model still provides a valuable framework on which to base immunological research. In this review we update the model with current thinking regarding the generation and maintenance of immune responses. We then examine how the Th1–Th2 paradigm may be applied in developing new understanding of several topical issues in haematological malignancy—control of graft-versus–host disease; cytokine control of proliferating clones in B and T cell diseases; and suppression of T cell responses in multiple myeloma.</description><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Biological and medical sciences</subject><subject>Cell interactions</subject><subject>Cytotoxicity, Immunologic</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematologic Neoplasms - immunology</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Medical sciences</subject><subject>Th1 Cells - classification</subject><subject>Th1 Cells - immunology</subject><subject>Th2 Cells - classification</subject><subject>Th2 Cells - immunology</subject><issn>0268-960X</issn><issn>1532-1681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE2L1TAUhoMozp3RrUsJCLOyd_LR5qbuZBhHYcDNFdyFND25jaZJTVphlvPPTblFV64OHJ7zct4HoTeU7Clp6pvOJ9gzQsieUC6eoR1tOKuokPQ52hEmZNUK8v0CXeb8o1AtF4eX6IJSympKyQ49HQfAx4FWx4Fh43XOzjqjZxcDjhYb8H7xOmE3jksAnCBPMWTIH7CJwcA05_fYLClBmPE8uPDThRPWocd6mvwWlLELeNAw6jn6eCpbj0ft3SnoYB5foRdW-wyvt3mFvn26O95-rh6-3n-5_fhQGS7kXFkreiNIo3mtbVl1lHct4aaupeYtYz3vKDDbmLoxoEVrWA-S9NZK2wE_1PwKXZ9zpxR_LZBnNbq89tMB4pLVgdVS1s2hgPszaFLMOYFVU3KjTo-KErVKV6t0tUpXq_Ry8HZLXroR-n_4ZrkA7zZA51LeptLb5b-cFJI1KyXPFBQLvx0klY2DIrl3Ccys-uj-98EfNWWgTQ</recordid><startdate>20001201</startdate><enddate>20001201</enddate><creator>Lappin, M.B.</creator><creator>Campbell, J.D.M.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20001201</creationdate><title>The Th1-Th2 classification of cellular immune responses: concepts, current thinking and applications in haematological malignancy</title><author>Lappin, M.B. ; Campbell, J.D.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-ff6dc605a34afc36b13b903c448a3922d3b1e2f5c45cea69c2de80dff8fbe3743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Biological and medical sciences</topic><topic>Cell interactions</topic><topic>Cytotoxicity, Immunologic</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematologic Neoplasms - immunology</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Medical sciences</topic><topic>Th1 Cells - classification</topic><topic>Th1 Cells - immunology</topic><topic>Th2 Cells - classification</topic><topic>Th2 Cells - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lappin, M.B.</creatorcontrib><creatorcontrib>Campbell, J.D.M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lappin, M.B.</au><au>Campbell, J.D.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Th1-Th2 classification of cellular immune responses: concepts, current thinking and applications in haematological malignancy</atitle><jtitle>Blood reviews</jtitle><addtitle>Blood Rev</addtitle><date>2000-12-01</date><risdate>2000</risdate><volume>14</volume><issue>4</issue><spage>228</spage><epage>239</epage><pages>228-239</pages><issn>0268-960X</issn><eissn>1532-1681</eissn><abstract>The finding that T cell immune responses could be divided into those promoting cell mediated immunity (Th1) and humoral responses (Th2) has had a profound effect on the understanding of immune response generation over the last 15 years. 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| fulltext | fulltext |
| identifier | ISSN: 0268-960X |
| ispartof | Blood reviews, 2000-12, Vol.14 (4), p.228-239 |
| issn | 0268-960X 1532-1681 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Analysis of the immune response. Humoral and cellular immunity Biological and medical sciences Cell interactions Cytotoxicity, Immunologic Fundamental and applied biological sciences. Psychology Fundamental immunology Hematologic and hematopoietic diseases Hematologic Neoplasms - immunology Humans Immunobiology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Medical sciences Th1 Cells - classification Th1 Cells - immunology Th2 Cells - classification Th2 Cells - immunology |
| title | The Th1-Th2 classification of cellular immune responses: concepts, current thinking and applications in haematological malignancy |
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