Degradation pathway of homoserine lactone bacterial signal molecules by halogen antimicrobials identified by liquid chromatography with photodiode array and mass spectrometric detection

The degradation pathway of acylated homoserine lactone bacterial signaling molecules by oxidizing hypochlorite and stabilized hypobromite antimicrobials has been characterized. A reversed-phase HPLC separation using a cyano column was developed to detect the parent lactones, lactone-hydrolysis produ...

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Veröffentlicht in:	Journal of Chromatography A 2000-11, Vol.898 (2), p.153-165
Hauptverfasser:	Michels, James J, Allain, Eric J, Borchardt, Scott A, Hu, Peifeng, McCoy, William F
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Butyrolactone - analogs & derivatives 4-Butyrolactone - metabolism Action of physical and chemical agents on bacteria Anti-Infective Agents - chemistry Bacteriology Biological and medical sciences Chromatography, High Pressure Liquid Fundamental and applied biological sciences. Psychology Homoserine lactone Hydrogen-Ion Concentration Kinetics Mass Spectrometry Microbiology Spectrophotometry, Ultraviolet
Online-Zugang:	Volltext
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