Endothelin-1-Induced Contraction of Mesenteric Small Arteries Is Mediated by Ryanodine Receptor Ca2+ Channels and Cyclic ADP-Ribose

Contraction of vascular smooth muscle by endothelin-1 is dependent on extracellular and intracellular Ca. However, the role of ryanodine-sensitive Ca stores in endothelin-1-induced contraction is unknown. Vascular contraction was measured in mesenteric small arteries (200-300 μm intraluminal diamete...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 2000-12, Vol.36 (6), p.758-763
Hauptverfasser:	Giulumian, Ararat D, Mészáros, László G, Fuchs, Leslie C
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate Ribose - analogs & derivatives Adenosine Diphosphate Ribose - pharmacology Animals Biological and medical sciences Blood vessels and receptors Calcium Channels - drug effects Cyclic ADP-Ribose Dantrolene - pharmacology Endothelin-1 - pharmacology Fundamental and applied biological sciences. Psychology Mesenteric Arteries - drug effects Muscle Relaxants, Central - pharmacology Muscle, Smooth, Vascular - drug effects Nitric Oxide Synthase - antagonists & inhibitors Nitric Oxide Synthase Type III Nitroarginine - pharmacology Potassium Channel Blockers Rats Rats, Sprague-Dawley Ryanodine Receptor Calcium Release Channel - drug effects Vertebrates: cardiovascular system
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