Hyperammonemia following allogeneic bone marrow transplantation
Hyperammonemia is a rare and serious complication of intensive cytotoxic chemotherapy. We report the case of a patient who developed profound idiopathic hyperammonemia following bone marrow transplantation for chronic myelogenous leukemia. Despite rapid institution of hemodialysis, sodium benzoate,...
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| Veröffentlicht in: | American journal of hematology 1991-10, Vol.38 (2), p.140-141 |
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| container_end_page | 141 |
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| container_issue | 2 |
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| container_title | American journal of hematology |
| container_volume | 38 |
| creator | Tse, Nielson Cederbaum, Stephen Glaspy, John A. |
| description | Hyperammonemia is a rare and serious complication of intensive cytotoxic chemotherapy. We report the case of a patient who developed profound idiopathic hyperammonemia following bone marrow transplantation for chronic myelogenous leukemia. Despite rapid institution of hemodialysis, sodium benzoate, and the experimental agent sodium phenylacetate, the patient ultimately succumbed to complications of this metabolic derangement. The literature is reviewed, and recommendations for an approach to this complication of marrow transplantation are proposed. |
| doi_str_mv | 10.1002/ajh.2830380213 |
| format | Article |
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We report the case of a patient who developed profound idiopathic hyperammonemia following bone marrow transplantation for chronic myelogenous leukemia. Despite rapid institution of hemodialysis, sodium benzoate, and the experimental agent sodium phenylacetate, the patient ultimately succumbed to complications of this metabolic derangement. The literature is reviewed, and recommendations for an approach to this complication of marrow transplantation are proposed.</description><identifier>ISSN: 0361-8609</identifier><identifier>EISSN: 1096-8652</identifier><identifier>DOI: 10.1002/ajh.2830380213</identifier><identifier>PMID: 1951305</identifier><identifier>CODEN: AJHEDD</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Ammonia - blood ; Anesthesia. Intensive care medicine. Transfusions. 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We report the case of a patient who developed profound idiopathic hyperammonemia following bone marrow transplantation for chronic myelogenous leukemia. Despite rapid institution of hemodialysis, sodium benzoate, and the experimental agent sodium phenylacetate, the patient ultimately succumbed to complications of this metabolic derangement. The literature is reviewed, and recommendations for an approach to this complication of marrow transplantation are proposed.</description><subject>Ammonia - blood</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Biological and medical sciences</subject><subject>Bone Marrow Transplantation - adverse effects</subject><subject>chronic myelogenous leukemia</subject><subject>cytotoxic chemotherapy</subject><subject>Female</subject><subject>Humans</subject><subject>hyperammonemia</subject><subject>Intensive care medicine</subject><subject>Medical sciences</subject><subject>Metabolic Diseases - surgery</subject><subject>Middle Aged</subject><subject>Renal Dialysis</subject><subject>Transplantation, Homologous</subject><issn>0361-8609</issn><issn>1096-8652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFPwyAYhonRzDm9ejPpwXjr_IBC6cksizrNEi-7E2B0srSlli7L_r2YLs6bJ77kffh4eRC6xTDFAORRbT-nRFCgAgimZ2iMoeCp4IycozFQjuMMxSW6CmELgHEmYIRGuGCYAhujp8WhtZ2qa9_Y2qmk9FXl967ZJCoOG9tYZxIdw6RWXef3Sd-pJrSVanrVO99co4tSVcHeHM8JWr08r-aLdPnx-jafLVOT8YymnJWGF8LofG0xsyXFQmhisAYNhaaYapvnuSZMMVISznJKjOWCiCw364LQCXoY1rad_9rZ0MvaBWOr2MP6XZA5yUSWCRbB6QCazofQ2VK2nYvVDxKD_BEmozB5EhYv3B0373Rt1yd8MBTz-2OuglFVGb9vXPjFGAYeZUesGLC9q-zhn0fl7H3xp8I36T6Dow</recordid><startdate>199110</startdate><enddate>199110</enddate><creator>Tse, Nielson</creator><creator>Cederbaum, Stephen</creator><creator>Glaspy, John A.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199110</creationdate><title>Hyperammonemia following allogeneic bone marrow transplantation</title><author>Tse, Nielson ; Cederbaum, Stephen ; Glaspy, John A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4643-65fc698cb7de15ef3188b2c1b0b09b313be777b25a52f265732ce682847cd923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Ammonia - blood</topic><topic>Anesthesia. 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Cell therapy and gene therapy</topic><topic>Biological and medical sciences</topic><topic>Bone Marrow Transplantation - adverse effects</topic><topic>chronic myelogenous leukemia</topic><topic>cytotoxic chemotherapy</topic><topic>Female</topic><topic>Humans</topic><topic>hyperammonemia</topic><topic>Intensive care medicine</topic><topic>Medical sciences</topic><topic>Metabolic Diseases - surgery</topic><topic>Middle Aged</topic><topic>Renal Dialysis</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tse, Nielson</creatorcontrib><creatorcontrib>Cederbaum, Stephen</creatorcontrib><creatorcontrib>Glaspy, John A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tse, Nielson</au><au>Cederbaum, Stephen</au><au>Glaspy, John A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hyperammonemia following allogeneic bone marrow transplantation</atitle><jtitle>American journal of hematology</jtitle><addtitle>Am J Hematol</addtitle><date>1991-10</date><risdate>1991</risdate><volume>38</volume><issue>2</issue><spage>140</spage><epage>141</epage><pages>140-141</pages><issn>0361-8609</issn><eissn>1096-8652</eissn><coden>AJHEDD</coden><abstract>Hyperammonemia is a rare and serious complication of intensive cytotoxic chemotherapy. We report the case of a patient who developed profound idiopathic hyperammonemia following bone marrow transplantation for chronic myelogenous leukemia. Despite rapid institution of hemodialysis, sodium benzoate, and the experimental agent sodium phenylacetate, the patient ultimately succumbed to complications of this metabolic derangement. The literature is reviewed, and recommendations for an approach to this complication of marrow transplantation are proposed.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>1951305</pmid><doi>10.1002/ajh.2830380213</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | American journal of hematology, 1991-10, Vol.38 (2), p.140-141 |
| issn | 0361-8609 1096-8652 |
| language | eng |
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| source | MEDLINE; Wiley Online Library All Journals |
| subjects | Ammonia - blood Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone Marrow Transplantation - adverse effects chronic myelogenous leukemia cytotoxic chemotherapy Female Humans hyperammonemia Intensive care medicine Medical sciences Metabolic Diseases - surgery Middle Aged Renal Dialysis Transplantation, Homologous |
| title | Hyperammonemia following allogeneic bone marrow transplantation |
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