Melatonin directly scavenges hydrogen peroxide: a potentially new metabolic pathway of melatonin biotransformation

A potential new metabolic pathway of melatonin biotransformation is described in this investigation. Melatonin was found to directly scavenge hydrogen peroxide (H 2O 2) to form N 1-acetyl-N 2-formyl-5-methoxykynuramine and, thereafter this compound could be enzymatically converted to N 1-acetyl-5-me...

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Veröffentlicht in:	Free radical biology & medicine 2000-12, Vol.29 (11), p.1177-1185
Hauptverfasser:	Tan, Dun-Xian, Manchester, Lucien C., Reiter, Russel J., Plummer, Benjamin F., Limson, Janice, Weintraub, Susan T., Qi, Wenbo
Format:	Artikel
Sprache:	eng
Schlagworte:	Catalase Catalase - metabolism Free radical Free Radical Scavengers Glutathione Peroxidase Hydrogen peroxide Hydrogen Peroxide - metabolism Hydroxyl Radical - metabolism Kinetics Kynuramine - metabolism Magnetic Resonance Spectroscopy Melatonin Melatonin - metabolism N 1-acetyl-5-methoxykynuramine N 1-acetyl-N 2 -formyl-5-methoxykynuramine
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