Induction of immune tolerance and suppression of anaphylaxis in a child with haemophilia B by simple plasmapheresis and antigen exposure

Induction of immune tolerance and suppression of anaphylaxis in a child with haemophilia B by simple plasmapheresis and antigen exposure

Anaphylaxis to factor IX (FIX) in patients with haemophilia B is a rare and life‐threatening complication that has been reported to occur in association with the development of inhibitors to FIX. Management of these patients is difficult. This report presents an 18‐month‐old boy with a frame‐shift m...

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Veröffentlicht in:Haemophilia : the official journal of the World Federation of Hemophilia 2000-11, Vol.6 (6), p.693-695
Hauptverfasser: Barnes, C., Rudzki, Z., Ekert, H.
Format: Artikel
Sprache:eng
Schlagworte:
anaphylaxis
Anaphylaxis - etiology
Anaphylaxis - immunology
Anaphylaxis - prevention & control
antigen exposure
Antigens - immunology
Factor IX - administration & dosage
Factor IX - adverse effects
Factor IX - immunology
factor IX inhibitor
Hemophilia B - drug therapy
Hemophilia B - immunology
Humans
Immune Tolerance
Infant
Male
Plasmapheresis
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Beschreibung
Zusammenfassung:Anaphylaxis to factor IX (FIX) in patients with haemophilia B is a rare and life‐threatening complication that has been reported to occur in association with the development of inhibitors to FIX. Management of these patients is difficult. This report presents an 18‐month‐old boy with a frame‐shift mutation of the FIX gene and FIX coagulant level of
ISSN:1351-8216
1365-2516
DOI:10.1046/j.1365-2516.2000.00419.x