Pharmacokinetics of transdermal fentanyl in the peri‐operative period in young children
The pharmacokinetics of transdermal fentanyl were assessed in eight children aged 18–60 months, weighing 11–20 kg and monitored postoperatively in the intensive care unit. A patch, delivering 25 µg.h−1 of fentanyl, was applied for 72 h from the induction of anaesthesia. Plasma fentanyl concentration...
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| Veröffentlicht in: | Anaesthesia 2000-12, Vol.55 (12), p.1202-1207 |
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| creator | Paut, O. Camboulives, J. Viard, L. Lemoing, J. P. Levron, J. C. |
| description | The pharmacokinetics of transdermal fentanyl were assessed in eight children aged 18–60 months, weighing 11–20 kg and monitored postoperatively in the intensive care unit. A patch, delivering 25 µg.h−1 of fentanyl, was applied for 72 h from the induction of anaesthesia. Plasma fentanyl concentrations were measured over 144 h. Mean (SD) peak concentration of fentanyl was 1.7 (0.66) ng.ml−1 and time to reach maximal plasma concentration was 18 (11) h. The elimination half‐life was 14.5 (6.2) h, and the area under the curve for plasma fentanyl concentration (0–144 h) was 86.8 (27) ng.h.ml−1. Maximal fentanyl concentration was negatively correlated with patient age (r = − 0.71; p = 0.049) but not with body weight. These results suggest that the pharmacokinetics of transdermal fentanyl in children are similar to those in adults. |
| doi_str_mv | 10.1046/j.1365-2044.2000.01615-3.x |
| format | Article |
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P. ; Levron, J. C.</creator><creatorcontrib>Paut, O. ; Camboulives, J. ; Viard, L. ; Lemoing, J. P. ; Levron, J. C.</creatorcontrib><description>The pharmacokinetics of transdermal fentanyl were assessed in eight children aged 18–60 months, weighing 11–20 kg and monitored postoperatively in the intensive care unit. A patch, delivering 25 µg.h−1 of fentanyl, was applied for 72 h from the induction of anaesthesia. Plasma fentanyl concentrations were measured over 144 h. Mean (SD) peak concentration of fentanyl was 1.7 (0.66) ng.ml−1 and time to reach maximal plasma concentration was 18 (11) h. The elimination half‐life was 14.5 (6.2) h, and the area under the curve for plasma fentanyl concentration (0–144 h) was 86.8 (27) ng.h.ml−1. Maximal fentanyl concentration was negatively correlated with patient age (r = − 0.71; p = 0.049) but not with body weight. 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P.</creatorcontrib><creatorcontrib>Levron, J. C.</creatorcontrib><title>Pharmacokinetics of transdermal fentanyl in the peri‐operative period in young children</title><title>Anaesthesia</title><addtitle>Anaesthesia</addtitle><description>The pharmacokinetics of transdermal fentanyl were assessed in eight children aged 18–60 months, weighing 11–20 kg and monitored postoperatively in the intensive care unit. A patch, delivering 25 µg.h−1 of fentanyl, was applied for 72 h from the induction of anaesthesia. Plasma fentanyl concentrations were measured over 144 h. Mean (SD) peak concentration of fentanyl was 1.7 (0.66) ng.ml−1 and time to reach maximal plasma concentration was 18 (11) h. The elimination half‐life was 14.5 (6.2) h, and the area under the curve for plasma fentanyl concentration (0–144 h) was 86.8 (27) ng.h.ml−1. Maximal fentanyl concentration was negatively correlated with patient age (r = − 0.71; p = 0.049) but not with body weight. These results suggest that the pharmacokinetics of transdermal fentanyl in children are similar to those in adults.</description><subject>Administration, Cutaneous</subject><subject>Age Factors</subject><subject>Analgesia</subject><subject>Analgesics</subject><subject>Analgesics, Opioid - blood</subject><subject>Analgesics, Opioid - pharmacokinetics</subject><subject>Area Under Curve</subject><subject>Biological and medical sciences</subject><subject>Body Weight</subject><subject>Child, Preschool</subject><subject>fentanyl</subject><subject>Fentanyl - blood</subject><subject>Fentanyl - pharmacokinetics</subject><subject>Half-Life</subject><subject>Humans</subject><subject>Infant</subject><subject>Intraoperative Care</subject><subject>Medical sciences</subject><subject>Neuropharmacology</subject><subject>paediatric</subject><subject>Pharmacology. 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C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4543-54af7f39c04f340a92ed7538c9d5278c9867b1a476b1f63535b8ffb476abdd353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Administration, Cutaneous</topic><topic>Age Factors</topic><topic>Analgesia</topic><topic>Analgesics</topic><topic>Analgesics, Opioid - blood</topic><topic>Analgesics, Opioid - pharmacokinetics</topic><topic>Area Under Curve</topic><topic>Biological and medical sciences</topic><topic>Body Weight</topic><topic>Child, Preschool</topic><topic>fentanyl</topic><topic>Fentanyl - blood</topic><topic>Fentanyl - pharmacokinetics</topic><topic>Half-Life</topic><topic>Humans</topic><topic>Infant</topic><topic>Intraoperative Care</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>paediatric</topic><topic>Pharmacology. Drug treatments</topic><topic>postoperative</topic><topic>transdermal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paut, O.</creatorcontrib><creatorcontrib>Camboulives, J.</creatorcontrib><creatorcontrib>Viard, L.</creatorcontrib><creatorcontrib>Lemoing, J. P.</creatorcontrib><creatorcontrib>Levron, J. C.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anaesthesia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paut, O.</au><au>Camboulives, J.</au><au>Viard, L.</au><au>Lemoing, J. P.</au><au>Levron, J. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pharmacokinetics of transdermal fentanyl in the peri‐operative period in young children</atitle><jtitle>Anaesthesia</jtitle><addtitle>Anaesthesia</addtitle><date>2000-12</date><risdate>2000</risdate><volume>55</volume><issue>12</issue><spage>1202</spage><epage>1207</epage><pages>1202-1207</pages><issn>0003-2409</issn><eissn>1365-2044</eissn><coden>ANASAB</coden><abstract>The pharmacokinetics of transdermal fentanyl were assessed in eight children aged 18–60 months, weighing 11–20 kg and monitored postoperatively in the intensive care unit. A patch, delivering 25 µg.h−1 of fentanyl, was applied for 72 h from the induction of anaesthesia. Plasma fentanyl concentrations were measured over 144 h. Mean (SD) peak concentration of fentanyl was 1.7 (0.66) ng.ml−1 and time to reach maximal plasma concentration was 18 (11) h. The elimination half‐life was 14.5 (6.2) h, and the area under the curve for plasma fentanyl concentration (0–144 h) was 86.8 (27) ng.h.ml−1. Maximal fentanyl concentration was negatively correlated with patient age (r = − 0.71; p = 0.049) but not with body weight. These results suggest that the pharmacokinetics of transdermal fentanyl in children are similar to those in adults.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>11121932</pmid><doi>10.1046/j.1365-2044.2000.01615-3.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Administration, Cutaneous Age Factors Analgesia Analgesics Analgesics, Opioid - blood Analgesics, Opioid - pharmacokinetics Area Under Curve Biological and medical sciences Body Weight Child, Preschool fentanyl Fentanyl - blood Fentanyl - pharmacokinetics Half-Life Humans Infant Intraoperative Care Medical sciences Neuropharmacology paediatric Pharmacology. Drug treatments postoperative transdermal |
| title | Pharmacokinetics of transdermal fentanyl in the peri‐operative period in young children |
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