Effect of mycobacterial infection on virus loads and disease progression in simian immunodeficiency virus-infected rhesus monkeys
The effect of a mycobacterial infection on AIDS disease was studied in the simian model. Monkeys were infected with the primary virulent isolate SIV/DeltaB670 and inoculated 90 days later with BCG, an attenuated strain of Mycobacterium bovis. All monkeys experienced a dramatic transient increase in...
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| Veröffentlicht in: | AIDS research and human retroviruses 2000-11, Vol.16 (17), p.1895-1908 |
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| container_title | AIDS research and human retroviruses |
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| creator | CROIX, Denise A CAPUANO, Saverio III SIMPSON, Laura FALLERT, Beth A FULLER, Craig L KLEIN, Edwin C REINHART, Todd A MURPHEY-CORB, Michael FLYNN, Joanne L |
| description | The effect of a mycobacterial infection on AIDS disease was studied in the simian model. Monkeys were infected with the primary virulent isolate SIV/DeltaB670 and inoculated 90 days later with BCG, an attenuated strain of Mycobacterium bovis. All monkeys experienced a dramatic transient increase in plasma viremia and CCR5 expression on T lymphocytes after BCG inoculation. Only two of the four SIV+ animals had substantial proliferative responses to PPD, with poor responders developing disseminated BCG during the course of the experiment. BCG inoculation of SIV-infected long-term nonprogressor (LTNP) monkeys was also performed. Similar to the acutely infected animals, two of three LTNPs experienced increases in plasma viral levels and CCR5 expression. In the majority of animals studied, there was no accelerated progression to AIDS despite the concomitant transient stimulation of virus replication and CCR5 expression on T lymphocytes. |
| doi_str_mv | 10.1089/08892220050195856 |
| format | Article |
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Monkeys were infected with the primary virulent isolate SIV/DeltaB670 and inoculated 90 days later with BCG, an attenuated strain of Mycobacterium bovis. All monkeys experienced a dramatic transient increase in plasma viremia and CCR5 expression on T lymphocytes after BCG inoculation. Only two of the four SIV+ animals had substantial proliferative responses to PPD, with poor responders developing disseminated BCG during the course of the experiment. BCG inoculation of SIV-infected long-term nonprogressor (LTNP) monkeys was also performed. Similar to the acutely infected animals, two of three LTNPs experienced increases in plasma viral levels and CCR5 expression. In the majority of animals studied, there was no accelerated progression to AIDS despite the concomitant transient stimulation of virus replication and CCR5 expression on T lymphocytes.</description><identifier>ISSN: 0889-2229</identifier><identifier>EISSN: 1931-8405</identifier><identifier>DOI: 10.1089/08892220050195856</identifier><identifier>PMID: 11118075</identifier><identifier>CODEN: ARHRE7</identifier><language>eng</language><publisher>Larchmont, NY: Liebert</publisher><subject>AIDS-Related Opportunistic Infections - immunology ; AIDS-Related Opportunistic Infections - microbiology ; AIDS/HIV ; Animals ; Biological and medical sciences ; Disease Models, Animal ; Disease Progression ; Experimental viral diseases and models ; Fundamental and applied biological sciences. Psychology ; Human viral diseases ; Humans ; In Situ Hybridization ; Infectious diseases ; Lymph Nodes - virology ; Lymphocyte Activation ; Macaca mulatta ; Medical sciences ; Microbiology ; Mycobacterium bovis ; Mycobacterium bovis - immunology ; Receptors, CCR5 - metabolism ; RNA, Viral - blood ; Simian Acquired Immunodeficiency Syndrome - complications ; Simian Acquired Immunodeficiency Syndrome - physiopathology ; Simian immunodeficiency virus ; Simian Immunodeficiency Virus - physiology ; Spleen - virology ; Survivors ; T-Lymphocytes - immunology ; Tuberculosis - immunology ; Tuberculosis - microbiology ; Tuberculosis - physiopathology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Load ; virulence factors</subject><ispartof>AIDS research and human retroviruses, 2000-11, Vol.16 (17), p.1895-1908</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c358t-7893f3accee032f62bcad654b25b90cf5f0201231387b154817a2dc6a4fda9f53</citedby><cites>FETCH-LOGICAL-c358t-7893f3accee032f62bcad654b25b90cf5f0201231387b154817a2dc6a4fda9f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,3043,27926,27927</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14161504$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11118075$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CROIX, Denise A</creatorcontrib><creatorcontrib>CAPUANO, Saverio III</creatorcontrib><creatorcontrib>SIMPSON, Laura</creatorcontrib><creatorcontrib>FALLERT, Beth A</creatorcontrib><creatorcontrib>FULLER, Craig L</creatorcontrib><creatorcontrib>KLEIN, Edwin C</creatorcontrib><creatorcontrib>REINHART, Todd A</creatorcontrib><creatorcontrib>MURPHEY-CORB, Michael</creatorcontrib><creatorcontrib>FLYNN, Joanne L</creatorcontrib><title>Effect of mycobacterial infection on virus loads and disease progression in simian immunodeficiency virus-infected rhesus monkeys</title><title>AIDS research and human retroviruses</title><addtitle>AIDS Res Hum Retroviruses</addtitle><description>The effect of a mycobacterial infection on AIDS disease was studied in the simian model. Monkeys were infected with the primary virulent isolate SIV/DeltaB670 and inoculated 90 days later with BCG, an attenuated strain of Mycobacterium bovis. All monkeys experienced a dramatic transient increase in plasma viremia and CCR5 expression on T lymphocytes after BCG inoculation. Only two of the four SIV+ animals had substantial proliferative responses to PPD, with poor responders developing disseminated BCG during the course of the experiment. BCG inoculation of SIV-infected long-term nonprogressor (LTNP) monkeys was also performed. Similar to the acutely infected animals, two of three LTNPs experienced increases in plasma viral levels and CCR5 expression. In the majority of animals studied, there was no accelerated progression to AIDS despite the concomitant transient stimulation of virus replication and CCR5 expression on T lymphocytes.</description><subject>AIDS-Related Opportunistic Infections - immunology</subject><subject>AIDS-Related Opportunistic Infections - microbiology</subject><subject>AIDS/HIV</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Disease Models, Animal</subject><subject>Disease Progression</subject><subject>Experimental viral diseases and models</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>In Situ Hybridization</subject><subject>Infectious diseases</subject><subject>Lymph Nodes - virology</subject><subject>Lymphocyte Activation</subject><subject>Macaca mulatta</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Mycobacterium bovis</subject><subject>Mycobacterium bovis - immunology</subject><subject>Receptors, CCR5 - metabolism</subject><subject>RNA, Viral - blood</subject><subject>Simian Acquired Immunodeficiency Syndrome - complications</subject><subject>Simian Acquired Immunodeficiency Syndrome - physiopathology</subject><subject>Simian immunodeficiency virus</subject><subject>Simian Immunodeficiency Virus - physiology</subject><subject>Spleen - virology</subject><subject>Survivors</subject><subject>T-Lymphocytes - immunology</subject><subject>Tuberculosis - immunology</subject><subject>Tuberculosis - microbiology</subject><subject>Tuberculosis - physiopathology</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viral Load</subject><subject>virulence factors</subject><issn>0889-2229</issn><issn>1931-8405</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFrFTEQxkNR7Gv1D_Aiueht7STZ7GaPUqoWCl7qeckmkxrdTWrmrfCO_c_N8h704MEwkGHm930MfIy9FfBRgBmuwJhBSgmgQQza6O6M7cSgRGNa0C_Ybts3FRjO2QXRTwCouH7FzkV9Bnq9Y083IaDb8xz4cnB5sm6PJdqZx7TNY0681p9YVuJztp64TZ77SGgJ-WPJDwWJNiwmTnGJtnbLsqbsMUQXMbnDUd4cHdHz8gOp2i05_cIDvWYvg50J35z-S_b988399dfm7tuX2-tPd41T2uyb3gwqKOscIigZOjk56zvdTlJPA7igA0gQUgll-kno1ojeSu862wZvh6DVJftw9K1H_16R9uMSyeE824R5pbGXrZGil_8FRd-3MIgNFEfQlUxUMIyPJS62HEYB4xbQ-E9AVfPuZL5OC_pnxSmRCrw_AZacnUOxyUV65lrRCQ2t-guUspqq</recordid><startdate>20001120</startdate><enddate>20001120</enddate><creator>CROIX, Denise A</creator><creator>CAPUANO, Saverio III</creator><creator>SIMPSON, Laura</creator><creator>FALLERT, Beth A</creator><creator>FULLER, Craig L</creator><creator>KLEIN, Edwin C</creator><creator>REINHART, Todd A</creator><creator>MURPHEY-CORB, Michael</creator><creator>FLYNN, Joanne L</creator><general>Liebert</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20001120</creationdate><title>Effect of mycobacterial infection on virus loads and disease progression in simian immunodeficiency virus-infected rhesus monkeys</title><author>CROIX, Denise A ; CAPUANO, Saverio III ; SIMPSON, Laura ; FALLERT, Beth A ; FULLER, Craig L ; KLEIN, Edwin C ; REINHART, Todd A ; MURPHEY-CORB, Michael ; FLYNN, Joanne L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c358t-7893f3accee032f62bcad654b25b90cf5f0201231387b154817a2dc6a4fda9f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>AIDS-Related Opportunistic Infections - immunology</topic><topic>AIDS-Related Opportunistic Infections - microbiology</topic><topic>AIDS/HIV</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Disease Models, Animal</topic><topic>Disease Progression</topic><topic>Experimental viral diseases and models</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>In Situ Hybridization</topic><topic>Infectious diseases</topic><topic>Lymph Nodes - virology</topic><topic>Lymphocyte Activation</topic><topic>Macaca mulatta</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Mycobacterium bovis</topic><topic>Mycobacterium bovis - immunology</topic><topic>Receptors, CCR5 - metabolism</topic><topic>RNA, Viral - blood</topic><topic>Simian Acquired Immunodeficiency Syndrome - complications</topic><topic>Simian Acquired Immunodeficiency Syndrome - physiopathology</topic><topic>Simian immunodeficiency virus</topic><topic>Simian Immunodeficiency Virus - physiology</topic><topic>Spleen - virology</topic><topic>Survivors</topic><topic>T-Lymphocytes - immunology</topic><topic>Tuberculosis - immunology</topic><topic>Tuberculosis - microbiology</topic><topic>Tuberculosis - physiopathology</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Viral Load</topic><topic>virulence factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CROIX, Denise A</creatorcontrib><creatorcontrib>CAPUANO, Saverio III</creatorcontrib><creatorcontrib>SIMPSON, Laura</creatorcontrib><creatorcontrib>FALLERT, Beth A</creatorcontrib><creatorcontrib>FULLER, Craig L</creatorcontrib><creatorcontrib>KLEIN, Edwin C</creatorcontrib><creatorcontrib>REINHART, Todd A</creatorcontrib><creatorcontrib>MURPHEY-CORB, Michael</creatorcontrib><creatorcontrib>FLYNN, Joanne L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>AIDS research and human retroviruses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CROIX, Denise A</au><au>CAPUANO, Saverio III</au><au>SIMPSON, Laura</au><au>FALLERT, Beth A</au><au>FULLER, Craig L</au><au>KLEIN, Edwin C</au><au>REINHART, Todd A</au><au>MURPHEY-CORB, Michael</au><au>FLYNN, Joanne L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of mycobacterial infection on virus loads and disease progression in simian immunodeficiency virus-infected rhesus monkeys</atitle><jtitle>AIDS research and human retroviruses</jtitle><addtitle>AIDS Res Hum Retroviruses</addtitle><date>2000-11-20</date><risdate>2000</risdate><volume>16</volume><issue>17</issue><spage>1895</spage><epage>1908</epage><pages>1895-1908</pages><issn>0889-2229</issn><eissn>1931-8405</eissn><coden>ARHRE7</coden><abstract>The effect of a mycobacterial infection on AIDS disease was studied in the simian model. Monkeys were infected with the primary virulent isolate SIV/DeltaB670 and inoculated 90 days later with BCG, an attenuated strain of Mycobacterium bovis. All monkeys experienced a dramatic transient increase in plasma viremia and CCR5 expression on T lymphocytes after BCG inoculation. Only two of the four SIV+ animals had substantial proliferative responses to PPD, with poor responders developing disseminated BCG during the course of the experiment. BCG inoculation of SIV-infected long-term nonprogressor (LTNP) monkeys was also performed. Similar to the acutely infected animals, two of three LTNPs experienced increases in plasma viral levels and CCR5 expression. In the majority of animals studied, there was no accelerated progression to AIDS despite the concomitant transient stimulation of virus replication and CCR5 expression on T lymphocytes.</abstract><cop>Larchmont, NY</cop><pub>Liebert</pub><pmid>11118075</pmid><doi>10.1089/08892220050195856</doi><tpages>14</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | AIDS research and human retroviruses, 2000-11, Vol.16 (17), p.1895-1908 |
| issn | 0889-2229 1931-8405 |
| language | eng |
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| source | Mary Ann Liebert Online Subscription; MEDLINE; Alma/SFX Local Collection |
| subjects | AIDS-Related Opportunistic Infections - immunology AIDS-Related Opportunistic Infections - microbiology AIDS/HIV Animals Biological and medical sciences Disease Models, Animal Disease Progression Experimental viral diseases and models Fundamental and applied biological sciences. Psychology Human viral diseases Humans In Situ Hybridization Infectious diseases Lymph Nodes - virology Lymphocyte Activation Macaca mulatta Medical sciences Microbiology Mycobacterium bovis Mycobacterium bovis - immunology Receptors, CCR5 - metabolism RNA, Viral - blood Simian Acquired Immunodeficiency Syndrome - complications Simian Acquired Immunodeficiency Syndrome - physiopathology Simian immunodeficiency virus Simian Immunodeficiency Virus - physiology Spleen - virology Survivors T-Lymphocytes - immunology Tuberculosis - immunology Tuberculosis - microbiology Tuberculosis - physiopathology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load virulence factors |
| title | Effect of mycobacterial infection on virus loads and disease progression in simian immunodeficiency virus-infected rhesus monkeys |
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