Antiandrogenic effects of novel androgen synthesis inhibitors on hormone-dependent prostate cancer

We have found that in addition to being potent inhibitors of 17alpha-hydroxylase/C17,20-lyase and/or 5alpha-reductase, some of our novel androgen synthesis inhibitors also interact with the mutated androgen receptor (AR) expressed in LNCaP prostate cancer cells and the wild-type AR expressed in horm...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2000-12, Vol.60 (23), p.6630-6640
Hauptverfasser:	LONG, Brian J, GRIGORYEV, Dmitry N, NNANE, Ivo P, YANG LIU, LING, Yang-Zhi, BRODIE, Angela M
Format:	Artikel
Sprache:	eng
Schlagworte:	5-alpha Reductase Inhibitors Androgen Antagonists - metabolism Androgen Antagonists - pharmacology Androgen Receptor Antagonists Androstadienes - pharmacology Animals Antineoplastic agents Antineoplastic Agents, Hormonal - metabolism Antineoplastic Agents, Hormonal - pharmacology Biological and medical sciences Cell Division - drug effects Cercopithecus aethiops Chemotherapy Finasteride - pharmacology Growth Inhibitors - metabolism Growth Inhibitors - pharmacology Humans Ketoconazole - pharmacology Male Medical sciences Mice Mice, Nude Mice, SCID Neoplasms, Hormone-Dependent - drug therapy Neoplasms, Hormone-Dependent - metabolism Neoplasms, Hormone-Dependent - pathology Oleanolic Acid - analogs & derivatives Pharmacology. Drug treatments Pregnadienes - metabolism Pregnadienes - pharmacology Prostatic Neoplasms - drug therapy Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Receptors, Androgen - metabolism Saponins Steroid 17-alpha-Hydroxylase - antagonists & inhibitors Tumor Cells, Cultured Xenograft Model Antitumor Assays
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