4-Aryl-2,4-dioxobutanoic Acid Inhibitors of HIV-1 Integrase and Viral Replication in Cells

Human immunodeficiency virus type 1 (HIV-1) is the etiological agent of acquired immunedeficiency syndrome (AIDS). The unique nature of the replicative cycle of HIV-1 provides many potential targets for chemotherapeutic intervention. One of these, the viral integrase, catalyzes the insertion of the...

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Veröffentlicht in:	Journal of medicinal chemistry 2000-12, Vol.43 (26), p.4923-4926
Hauptverfasser:	Wai, John S, Egbertson, Melissa S, Payne, Linda S, Fisher, Thorsten E, Embrey, Mark W, Tran, Lekhanh O, Melamed, Jeffrey Y, Langford, H. Marie, Guare, James P, Zhuang, Linghang, Grey, Vanessa E, Vacca, Joseph P, Holloway, M. Katharine, Naylor-Olsen, Adel M, Hazuda, Daria J, Felock, Peter J, Wolfe, Abigail L, Stillmock, Kara A, Schleif, William A, Gabryelski, Lori J, Young, Steven D
Format:	Artikel
Sprache:	eng
Schlagworte:	4-Aryl-2,4-dioxobutanoic acid Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Biological and medical sciences Butyrates - chemical synthesis Butyrates - chemistry Butyrates - pharmacology Cell Line HIV HIV Integrase Inhibitors - chemical synthesis HIV Integrase Inhibitors - chemistry HIV Integrase Inhibitors - pharmacology Human immunodeficiency virus 1 Humans Medical sciences Pharmacology. Drug treatments Structure-Activity Relationship Virus Replication - drug effects
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