Bacteria in the transfer catheter tip influence the live-birth rate after in vitro fertilization
Objective: To assess the impact of individual bacteria isolated from the vagina and tip of the embryo transfer catheter on live-birth rates. Design: Prospective clinical study. Setting: Infertility outpatient clinic of a university hospital. Patient(s): Ninety-one women undergoing IVF-ET. Interventi...
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| Veröffentlicht in: | Fertility and sterility 2000-12, Vol.74 (6), p.1118-1124 |
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| creator | Moore, Donald E Soules, Michael R Klein, Nancy A Fujimoto, Victor Y Agnew, Kathy J Eschenbach, David A |
| description | Objective: To assess the impact of individual bacteria isolated from the vagina and tip of the embryo transfer catheter on live-birth rates.
Design: Prospective clinical study.
Setting: Infertility outpatient clinic of a university hospital.
Patient(s): Ninety-one women undergoing IVF-ET.
Intervention(s): Cultures were obtained from the vagina for aerobic and anaerobic bacteria at the time of both sonographic egg retrieval and embryo transfer and from the tip of the embryo transfer catheter. Doxycycline treatment was started after egg retrieval.
Main Outcome Measure(s): The live birth of one or more neonates.
Result(s): Doxycycline had no substantial impact on the recovery of individual vaginal bacteria or on bacterial vaginosis. An increase in live-birth rate was associated with the recovery of hydrogen peroxide–producing
Lactobacillus from the vagina (
P=0.01) and from the embryo transfer catheter (
P=0.01). In contrast, a reduction in live-birth rate was associated with recovery of
Streptococcus viridans (
S. viridans) from the embryo transfer catheter tip (
P=0.04).
Conclusion(s): In the setting of IVF-ET, prophylactic doxycycline had little effect on vaginal bacteria. Specific bacteria recovered from the embryo transfer catheter appear associated with a detrimental or beneficial effect or with no effect on live-birth rates. |
| doi_str_mv | 10.1016/S0015-0282(00)01624-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72479355</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0015028200016241</els_id><sourcerecordid>72479355</sourcerecordid><originalsourceid>FETCH-LOGICAL-c488t-62238eaf75c1a9329de929749c75a04dfb5f9a55a8af131b1b42c1b9966d5bad3</originalsourceid><addsrcrecordid>eNqFkE2P0zAQhi0Eot2FnwCyhIR2DwF_xHF8WkEFC1IlDsDZTJyxapQmxXYqwa_HaavliC-WZ553xnoIecHZG8548_YrY1xVTLTihrHbUhF1xR-RNVeqqVSj5GOyfkBW5Cqln4yxhmvxlKx4OUZLvSY_3oPLGAPQMNK8Q5ojjMljpA7Ks7RoDofS9MOMo8MTM4QjVl2IeUcjZKTgF64MOIYcJ1rSOQzhD-Qwjc_IEw9DwueX-5p8__jh2-ZTtf1y_3nzblu5um1z1QghWwSvleNgpDA9GmF0bZxWwOred8obUApa8Fzyjne1cLwzpml61UEvr8nr89xDnH7NmLLdh-RwGGDEaU5Wi1obqVQB1Rl0cUoporeHGPYQf1vO7KLWntTaxZtlzJ7UWl5yLy8L5m6P_b_UxWUBXl0ASA4GX0S6kB64VmojFuruTGGRcQwYbXJhMduHiC7bfgr_-chfGUyVxg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>72479355</pqid></control><display><type>article</type><title>Bacteria in the transfer catheter tip influence the live-birth rate after in vitro fertilization</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Moore, Donald E ; Soules, Michael R ; Klein, Nancy A ; Fujimoto, Victor Y ; Agnew, Kathy J ; Eschenbach, David A</creator><creatorcontrib>Moore, Donald E ; Soules, Michael R ; Klein, Nancy A ; Fujimoto, Victor Y ; Agnew, Kathy J ; Eschenbach, David A</creatorcontrib><description>Objective: To assess the impact of individual bacteria isolated from the vagina and tip of the embryo transfer catheter on live-birth rates.
Design: Prospective clinical study.
Setting: Infertility outpatient clinic of a university hospital.
Patient(s): Ninety-one women undergoing IVF-ET.
Intervention(s): Cultures were obtained from the vagina for aerobic and anaerobic bacteria at the time of both sonographic egg retrieval and embryo transfer and from the tip of the embryo transfer catheter. Doxycycline treatment was started after egg retrieval.
Main Outcome Measure(s): The live birth of one or more neonates.
Result(s): Doxycycline had no substantial impact on the recovery of individual vaginal bacteria or on bacterial vaginosis. An increase in live-birth rate was associated with the recovery of hydrogen peroxide–producing
Lactobacillus from the vagina (
P=0.01) and from the embryo transfer catheter (
P=0.01). In contrast, a reduction in live-birth rate was associated with recovery of
Streptococcus viridans (
S. viridans) from the embryo transfer catheter tip (
P=0.04).
Conclusion(s): In the setting of IVF-ET, prophylactic doxycycline had little effect on vaginal bacteria. Specific bacteria recovered from the embryo transfer catheter appear associated with a detrimental or beneficial effect or with no effect on live-birth rates.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(00)01624-1</identifier><identifier>PMID: 11119737</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adult ; Anti-Bacterial Agents - therapeutic use ; Bacteria - drug effects ; Bacteria - isolation & purification ; Biological and medical sciences ; Birth control ; Birth Rate ; Catheterization ; Doxycycline - therapeutic use ; Embryo Transfer ; Equipment Contamination ; Female ; Fertilization in Vitro ; Gynecology. Andrology. Obstetrics ; Humans ; Infection ; IVF-ET ; Lactobacillus - isolation & purification ; Medical sciences ; prophylactic antibiotics ; Prospective Studies ; Sterility. Assisted procreation ; Streptococcus - isolation & purification ; transfer catheter ; Vagina - microbiology ; Vaginosis, Bacterial - drug therapy ; Vaginosis, Bacterial - microbiology</subject><ispartof>Fertility and sterility, 2000-12, Vol.74 (6), p.1118-1124</ispartof><rights>2000 American Society for Reproductive Medicine</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c488t-62238eaf75c1a9329de929749c75a04dfb5f9a55a8af131b1b42c1b9966d5bad3</citedby><cites>FETCH-LOGICAL-c488t-62238eaf75c1a9329de929749c75a04dfb5f9a55a8af131b1b42c1b9966d5bad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015028200016241$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=837927$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11119737$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moore, Donald E</creatorcontrib><creatorcontrib>Soules, Michael R</creatorcontrib><creatorcontrib>Klein, Nancy A</creatorcontrib><creatorcontrib>Fujimoto, Victor Y</creatorcontrib><creatorcontrib>Agnew, Kathy J</creatorcontrib><creatorcontrib>Eschenbach, David A</creatorcontrib><title>Bacteria in the transfer catheter tip influence the live-birth rate after in vitro fertilization</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective: To assess the impact of individual bacteria isolated from the vagina and tip of the embryo transfer catheter on live-birth rates.
Design: Prospective clinical study.
Setting: Infertility outpatient clinic of a university hospital.
Patient(s): Ninety-one women undergoing IVF-ET.
Intervention(s): Cultures were obtained from the vagina for aerobic and anaerobic bacteria at the time of both sonographic egg retrieval and embryo transfer and from the tip of the embryo transfer catheter. Doxycycline treatment was started after egg retrieval.
Main Outcome Measure(s): The live birth of one or more neonates.
Result(s): Doxycycline had no substantial impact on the recovery of individual vaginal bacteria or on bacterial vaginosis. An increase in live-birth rate was associated with the recovery of hydrogen peroxide–producing
Lactobacillus from the vagina (
P=0.01) and from the embryo transfer catheter (
P=0.01). In contrast, a reduction in live-birth rate was associated with recovery of
Streptococcus viridans (
S. viridans) from the embryo transfer catheter tip (
P=0.04).
Conclusion(s): In the setting of IVF-ET, prophylactic doxycycline had little effect on vaginal bacteria. Specific bacteria recovered from the embryo transfer catheter appear associated with a detrimental or beneficial effect or with no effect on live-birth rates.</description><subject>Adult</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Bacteria - drug effects</subject><subject>Bacteria - isolation & purification</subject><subject>Biological and medical sciences</subject><subject>Birth control</subject><subject>Birth Rate</subject><subject>Catheterization</subject><subject>Doxycycline - therapeutic use</subject><subject>Embryo Transfer</subject><subject>Equipment Contamination</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infection</subject><subject>IVF-ET</subject><subject>Lactobacillus - isolation & purification</subject><subject>Medical sciences</subject><subject>prophylactic antibiotics</subject><subject>Prospective Studies</subject><subject>Sterility. Assisted procreation</subject><subject>Streptococcus - isolation & purification</subject><subject>transfer catheter</subject><subject>Vagina - microbiology</subject><subject>Vaginosis, Bacterial - drug therapy</subject><subject>Vaginosis, Bacterial - microbiology</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE2P0zAQhi0Eot2FnwCyhIR2DwF_xHF8WkEFC1IlDsDZTJyxapQmxXYqwa_HaavliC-WZ553xnoIecHZG8548_YrY1xVTLTihrHbUhF1xR-RNVeqqVSj5GOyfkBW5Cqln4yxhmvxlKx4OUZLvSY_3oPLGAPQMNK8Q5ojjMljpA7Ks7RoDofS9MOMo8MTM4QjVl2IeUcjZKTgF64MOIYcJ1rSOQzhD-Qwjc_IEw9DwueX-5p8__jh2-ZTtf1y_3nzblu5um1z1QghWwSvleNgpDA9GmF0bZxWwOred8obUApa8Fzyjne1cLwzpml61UEvr8nr89xDnH7NmLLdh-RwGGDEaU5Wi1obqVQB1Rl0cUoporeHGPYQf1vO7KLWntTaxZtlzJ7UWl5yLy8L5m6P_b_UxWUBXl0ASA4GX0S6kB64VmojFuruTGGRcQwYbXJhMduHiC7bfgr_-chfGUyVxg</recordid><startdate>20001201</startdate><enddate>20001201</enddate><creator>Moore, Donald E</creator><creator>Soules, Michael R</creator><creator>Klein, Nancy A</creator><creator>Fujimoto, Victor Y</creator><creator>Agnew, Kathy J</creator><creator>Eschenbach, David A</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20001201</creationdate><title>Bacteria in the transfer catheter tip influence the live-birth rate after in vitro fertilization</title><author>Moore, Donald E ; Soules, Michael R ; Klein, Nancy A ; Fujimoto, Victor Y ; Agnew, Kathy J ; Eschenbach, David A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c488t-62238eaf75c1a9329de929749c75a04dfb5f9a55a8af131b1b42c1b9966d5bad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Adult</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Bacteria - drug effects</topic><topic>Bacteria - isolation & purification</topic><topic>Biological and medical sciences</topic><topic>Birth control</topic><topic>Birth Rate</topic><topic>Catheterization</topic><topic>Doxycycline - therapeutic use</topic><topic>Embryo Transfer</topic><topic>Equipment Contamination</topic><topic>Female</topic><topic>Fertilization in Vitro</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Infection</topic><topic>IVF-ET</topic><topic>Lactobacillus - isolation & purification</topic><topic>Medical sciences</topic><topic>prophylactic antibiotics</topic><topic>Prospective Studies</topic><topic>Sterility. Assisted procreation</topic><topic>Streptococcus - isolation & purification</topic><topic>transfer catheter</topic><topic>Vagina - microbiology</topic><topic>Vaginosis, Bacterial - drug therapy</topic><topic>Vaginosis, Bacterial - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moore, Donald E</creatorcontrib><creatorcontrib>Soules, Michael R</creatorcontrib><creatorcontrib>Klein, Nancy A</creatorcontrib><creatorcontrib>Fujimoto, Victor Y</creatorcontrib><creatorcontrib>Agnew, Kathy J</creatorcontrib><creatorcontrib>Eschenbach, David A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moore, Donald E</au><au>Soules, Michael R</au><au>Klein, Nancy A</au><au>Fujimoto, Victor Y</au><au>Agnew, Kathy J</au><au>Eschenbach, David A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bacteria in the transfer catheter tip influence the live-birth rate after in vitro fertilization</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2000-12-01</date><risdate>2000</risdate><volume>74</volume><issue>6</issue><spage>1118</spage><epage>1124</epage><pages>1118-1124</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Objective: To assess the impact of individual bacteria isolated from the vagina and tip of the embryo transfer catheter on live-birth rates.
Design: Prospective clinical study.
Setting: Infertility outpatient clinic of a university hospital.
Patient(s): Ninety-one women undergoing IVF-ET.
Intervention(s): Cultures were obtained from the vagina for aerobic and anaerobic bacteria at the time of both sonographic egg retrieval and embryo transfer and from the tip of the embryo transfer catheter. Doxycycline treatment was started after egg retrieval.
Main Outcome Measure(s): The live birth of one or more neonates.
Result(s): Doxycycline had no substantial impact on the recovery of individual vaginal bacteria or on bacterial vaginosis. An increase in live-birth rate was associated with the recovery of hydrogen peroxide–producing
Lactobacillus from the vagina (
P=0.01) and from the embryo transfer catheter (
P=0.01). In contrast, a reduction in live-birth rate was associated with recovery of
Streptococcus viridans (
S. viridans) from the embryo transfer catheter tip (
P=0.04).
Conclusion(s): In the setting of IVF-ET, prophylactic doxycycline had little effect on vaginal bacteria. Specific bacteria recovered from the embryo transfer catheter appear associated with a detrimental or beneficial effect or with no effect on live-birth rates.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>11119737</pmid><doi>10.1016/S0015-0282(00)01624-1</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Anti-Bacterial Agents - therapeutic use Bacteria - drug effects Bacteria - isolation & purification Biological and medical sciences Birth control Birth Rate Catheterization Doxycycline - therapeutic use Embryo Transfer Equipment Contamination Female Fertilization in Vitro Gynecology. Andrology. Obstetrics Humans Infection IVF-ET Lactobacillus - isolation & purification Medical sciences prophylactic antibiotics Prospective Studies Sterility. Assisted procreation Streptococcus - isolation & purification transfer catheter Vagina - microbiology Vaginosis, Bacterial - drug therapy Vaginosis, Bacterial - microbiology |
| title | Bacteria in the transfer catheter tip influence the live-birth rate after in vitro fertilization |
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