Preliminary investigation of the mechanism of inhibition of bovine lymphocyte proliferation by Pasteurella haemolytica A1 leukotoxin
Pasteurella haemolytica A1 leukotoxic culture supernate has been shown to inhibit bovine lymphocyte blastogenesis induced by concanavalin A (Con A), pokeweed mitogen (PWM) and purified protein derivative (PPD). The various mechanisms by which this inhibition could be overcome were investigated in an...
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| Veröffentlicht in: | Veterinary immunology and immunopathology 1991-08, Vol.29 (1), p.57-68 |
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| creator | Majury, A.L. Shewen, P.E. |
| description | Pasteurella haemolytica A1 leukotoxic culture supernate has been shown to inhibit bovine lymphocyte blastogenesis induced by concanavalin A (Con A), pokeweed mitogen (PWM) and purified protein derivative (PPD). The various mechanisms by which this inhibition could be overcome were investigated in an effort to determine at which stage of cell activation the leukotoxin exerted its inhibitory effect. For both Con A and PWM stimulated cultures, the addition of partially purified bovine interleukin 1 reduced the leukotoxin-induced inhibition. Recombinant interleukin 2 had a similar effect. Addition of the glycolipid, monosialoganglioside was also able partially to overcome the inhibition. |
| doi_str_mv | 10.1016/0165-2427(91)90052-E |
| format | Article |
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The various mechanisms by which this inhibition could be overcome were investigated in an effort to determine at which stage of cell activation the leukotoxin exerted its inhibitory effect. For both Con A and PWM stimulated cultures, the addition of partially purified bovine interleukin 1 reduced the leukotoxin-induced inhibition. Recombinant interleukin 2 had a similar effect. Addition of the glycolipid, monosialoganglioside was also able partially to overcome the inhibition.</description><identifier>ISSN: 0165-2427</identifier><identifier>EISSN: 1873-2534</identifier><identifier>DOI: 10.1016/0165-2427(91)90052-E</identifier><identifier>PMID: 1949583</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Animals ; B-Lymphocytes - immunology ; Bacterial Toxins - immunology ; Bacteriology ; Biological and medical sciences ; BOVIN ; CATTLE ; Culture Media ; Exotoxins - immunology ; Fundamental and applied biological sciences. 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The various mechanisms by which this inhibition could be overcome were investigated in an effort to determine at which stage of cell activation the leukotoxin exerted its inhibitory effect. For both Con A and PWM stimulated cultures, the addition of partially purified bovine interleukin 1 reduced the leukotoxin-induced inhibition. Recombinant interleukin 2 had a similar effect. Addition of the glycolipid, monosialoganglioside was also able partially to overcome the inhibition.</description><subject>Animals</subject><subject>B-Lymphocytes - immunology</subject><subject>Bacterial Toxins - immunology</subject><subject>Bacteriology</subject><subject>Biological and medical sciences</subject><subject>BOVIN</subject><subject>CATTLE</subject><subject>Culture Media</subject><subject>Exotoxins - immunology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>G(M1) Ganglioside - pharmacology</subject><subject>GANADO BOVINO</subject><subject>Interleukin-2 - pharmacology</subject><subject>LEUCOCITOS</subject><subject>LEUCOCYTE</subject><subject>LEUKOCYTES</subject><subject>LINFOCITOS</subject><subject>LYMPHOCYTE</subject><subject>Lymphocyte Activation - immunology</subject><subject>LYMPHOCYTES</subject><subject>Mannheimia haemolytica - immunology</subject><subject>Microbiology</subject><subject>PASTEURELLA</subject><subject>Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains</subject><subject>Recombinant Proteins - pharmacology</subject><subject>T-Lymphocytes - immunology</subject><subject>TOXINAS</subject><subject>TOXINE</subject><subject>TOXINS</subject><issn>0165-2427</issn><issn>1873-2534</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU-L1DAYxoMo67j6BUShBxE9VJM2TZOLsCyzKgy6Bz2Ht-nbnWibjEk72LsffFM7rjc9hECe3_snz0PIM0bfMMrE23SqvOBF_Uqx14rSqsi398iGybrMi6rk98nmDnlIHsX4jSZISXlGzpjiqpLlhvy6DtjbwToIc2bdEeNob2C03mW-y8Y9ZgOaPTgbh-XBur1t7B-58UfrMOvn4bD3Zh4xOwTf2w7D2qGZs2uII05pRg_ZHnDw_TxaA9kFy3qcvvvR_7TuMXnQQR_xyek-J1-vtl8uP-S7z-8_Xl7scsNLMeZNywWl0AhTAjIpVV0WkrZgGmq4LJSCtqN1wwxUFTDaGdO1lWEKoFAgFZTn5OXaN635Y0pf1YONZtnNoZ-irgteS1Gz_4JMML54m0C-gib4GAN2-hDskLzUjOolJb1geolAK6Z_p6S3qez5qf_UDNj-LVpjSfqLkw7RQN8FcMbGO4wrLhSjCXu6Yh14DTchIZ92SRCiEEl8t4qYHD1aDDoai85gawOaUbfe_nvJW01ducA</recordid><startdate>19910801</startdate><enddate>19910801</enddate><creator>Majury, A.L.</creator><creator>Shewen, P.E.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19910801</creationdate><title>Preliminary investigation of the mechanism of inhibition of bovine lymphocyte proliferation by Pasteurella haemolytica A1 leukotoxin</title><author>Majury, A.L. ; Shewen, P.E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-bd4600ab6c3ae188973280dacb0c48299adf07b1ca55a10fccfd5c19aa29a89a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>B-Lymphocytes - immunology</topic><topic>Bacterial Toxins - immunology</topic><topic>Bacteriology</topic><topic>Biological and medical sciences</topic><topic>BOVIN</topic><topic>CATTLE</topic><topic>Culture Media</topic><topic>Exotoxins - immunology</topic><topic>Fundamental and applied biological sciences. 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The various mechanisms by which this inhibition could be overcome were investigated in an effort to determine at which stage of cell activation the leukotoxin exerted its inhibitory effect. For both Con A and PWM stimulated cultures, the addition of partially purified bovine interleukin 1 reduced the leukotoxin-induced inhibition. Recombinant interleukin 2 had a similar effect. Addition of the glycolipid, monosialoganglioside was also able partially to overcome the inhibition.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>1949583</pmid><doi>10.1016/0165-2427(91)90052-E</doi><tpages>12</tpages></addata></record> |
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| ispartof | Veterinary immunology and immunopathology, 1991-08, Vol.29 (1), p.57-68 |
| issn | 0165-2427 1873-2534 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals B-Lymphocytes - immunology Bacterial Toxins - immunology Bacteriology Biological and medical sciences BOVIN CATTLE Culture Media Exotoxins - immunology Fundamental and applied biological sciences. Psychology G(M1) Ganglioside - pharmacology GANADO BOVINO Interleukin-2 - pharmacology LEUCOCITOS LEUCOCYTE LEUKOCYTES LINFOCITOS LYMPHOCYTE Lymphocyte Activation - immunology LYMPHOCYTES Mannheimia haemolytica - immunology Microbiology PASTEURELLA Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Recombinant Proteins - pharmacology T-Lymphocytes - immunology TOXINAS TOXINE TOXINS |
| title | Preliminary investigation of the mechanism of inhibition of bovine lymphocyte proliferation by Pasteurella haemolytica A1 leukotoxin |
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