The Pharmacokinetics, Distribution and Degradation of Human Recombinant Interleukin 1β in Normal Rats

Based upon in vivo rat experiments it was recently suggested that interleukin I in the circulation may be implicated in the initial events of β‐cell destruction leading to insulin‐dependent diabetes mellitus (IDDM) in humans. The aim of the present study was to estimate half‐lives of distribution an...

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Veröffentlicht in:	Scandinavian journal of immunology 1991-11, Vol.34 (5), p.597-617
Hauptverfasser:	REIMERS, J., WOGENSEN, L. D., WELINDER, B., HEJNÆS, K. R., POULSEN, S. S., NILSSON, P., NERUP, J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography Biological and medical sciences Half-Life Immunomodulators Interleukin-1 - administration & dosage Interleukin-1 - pharmacokinetics Iodine Radioisotopes Male Medical sciences Metabolic Clearance Rate Pharmacology. Drug treatments Protein Binding Rats Rats, Inbred Strains Recombinant Proteins - administration & dosage Recombinant Proteins - pharmacokinetics Tissue Distribution Tumor Necrosis Factor-alpha - pharmacokinetics
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