Insignificant transfer of glyburide occurs across the human placenta
No data exist concerning human placental transfer of oral hypoglycemic agents during pregnancy. This study characterizes the transport of glyburide in 10 term human placentas with the single-cotyledon placental model. Serial samples were taken from both the maternal and fetal reservoirs during each...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1991-10, Vol.165 (4), p.807-812 |
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| container_title | American journal of obstetrics and gynecology |
| container_volume | 165 |
| creator | Elliott, Byron D. Langer, Oded Schenker, Steve Johnson, Raymond F. |
| description | No data exist concerning human placental transfer of oral hypoglycemic agents during pregnancy. This study characterizes the transport of glyburide in 10 term human placentas with the single-cotyledon placental model. Serial samples were taken from both the maternal and fetal reservoirs during each 3-hour perfusion, and the percent transport and metabolism of tritiated glyburide was calculated with liquid scintillation spectrometry and high-performance liquid chromatography. Antipyrine labeled with carbon 14 was added to the perfusate solution during these experiments as a control. Virtually no transfer of glyburide occurred, and no appreciable metabolism of the drug was detected. Neither variation in the albumin concentration nor increase in the maternal glyburide levels to 100 times therapeutic concentration materially altered the rate of transport. These data show that insignificant transport of glyburide occurs across the human placenta in vitro and suggest that fetal exposure to maternally administered glyburide likewise may be insignificant. |
| doi_str_mv | 10.1016/0002-9378(91)90421-M |
| format | Article |
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This study characterizes the transport of glyburide in 10 term human placentas with the single-cotyledon placental model. Serial samples were taken from both the maternal and fetal reservoirs during each 3-hour perfusion, and the percent transport and metabolism of tritiated glyburide was calculated with liquid scintillation spectrometry and high-performance liquid chromatography. Antipyrine labeled with carbon 14 was added to the perfusate solution during these experiments as a control. Virtually no transfer of glyburide occurred, and no appreciable metabolism of the drug was detected. Neither variation in the albumin concentration nor increase in the maternal glyburide levels to 100 times therapeutic concentration materially altered the rate of transport. These data show that insignificant transport of glyburide occurs across the human placenta in vitro and suggest that fetal exposure to maternally administered glyburide likewise may be insignificant.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/0002-9378(91)90421-M</identifier><identifier>PMID: 1951536</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Mosby, Inc</publisher><subject>Biological and medical sciences ; diazepam ; Diazepam - pharmacokinetics ; Female ; General and cellular metabolism. Vitamins ; Glyburide ; Glyburide - pharmacokinetics ; Humans ; Maternal-Fetal Exchange ; Medical sciences ; Models, Biological ; Pharmacology. Drug treatments ; placenta ; Placenta - metabolism ; Pregnancy ; pregnancy, human</subject><ispartof>American journal of obstetrics and gynecology, 1991-10, Vol.165 (4), p.807-812</ispartof><rights>1991 Mosby</rights><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-a8469d00b42bbc9b48b076688afb02e18158ddb1bb8581b0941c9edd0b0499493</citedby><cites>FETCH-LOGICAL-c437t-a8469d00b42bbc9b48b076688afb02e18158ddb1bb8581b0941c9edd0b0499493</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9378(91)90421-M$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,778,782,787,788,3539,23917,23918,25127,27911,27912,45982</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5579565$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1951536$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Elliott, Byron D.</creatorcontrib><creatorcontrib>Langer, Oded</creatorcontrib><creatorcontrib>Schenker, Steve</creatorcontrib><creatorcontrib>Johnson, Raymond F.</creatorcontrib><title>Insignificant transfer of glyburide occurs across the human placenta</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>No data exist concerning human placental transfer of oral hypoglycemic agents during pregnancy. This study characterizes the transport of glyburide in 10 term human placentas with the single-cotyledon placental model. Serial samples were taken from both the maternal and fetal reservoirs during each 3-hour perfusion, and the percent transport and metabolism of tritiated glyburide was calculated with liquid scintillation spectrometry and high-performance liquid chromatography. Antipyrine labeled with carbon 14 was added to the perfusate solution during these experiments as a control. Virtually no transfer of glyburide occurred, and no appreciable metabolism of the drug was detected. Neither variation in the albumin concentration nor increase in the maternal glyburide levels to 100 times therapeutic concentration materially altered the rate of transport. These data show that insignificant transport of glyburide occurs across the human placenta in vitro and suggest that fetal exposure to maternally administered glyburide likewise may be insignificant.</description><subject>Biological and medical sciences</subject><subject>diazepam</subject><subject>Diazepam - pharmacokinetics</subject><subject>Female</subject><subject>General and cellular metabolism. Vitamins</subject><subject>Glyburide</subject><subject>Glyburide - pharmacokinetics</subject><subject>Humans</subject><subject>Maternal-Fetal Exchange</subject><subject>Medical sciences</subject><subject>Models, Biological</subject><subject>Pharmacology. Drug treatments</subject><subject>placenta</subject><subject>Placenta - metabolism</subject><subject>Pregnancy</subject><subject>pregnancy, human</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1Lw0AQhhdRav34Bwo5iOghuptssrsXQepXocWLnpf9mLQraVJ3E6H_3qQp9eZpGOaZmZcHoQuC7wgm-T3GOIlFyviNILcC04TE8wM0JliwOOc5P0TjPXKMTkL46ttEJCM0IiIjWZqP0dO0Cm5RucIZVTVR41UVCvBRXUSLcqNb7yxEtTGtD5Eyvg4hapYQLduVqqJ1qQxUjTpDR4UqA5zv6in6fHn-mLzFs_fX6eRxFhuasiZWnObCYqxporURmnKNWZ5zrgqNEyCcZNxaTbTmGScaC0qMAGuxxlQIKtJTdD3cXfv6u4XQyJULBspSVVC3QbKEMpaIrAPpAG4Teyjk2ruV8htJsOzlyV6F7M1IQeRWnpx3a5e7-61egf1bGmx186vdXAWjyqKTZVzYY1nGRJb33x8GDDoXPw68DMZBZcA6D6aRtnb_5_gFCVGKtg</recordid><startdate>19911001</startdate><enddate>19911001</enddate><creator>Elliott, Byron D.</creator><creator>Langer, Oded</creator><creator>Schenker, Steve</creator><creator>Johnson, Raymond F.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19911001</creationdate><title>Insignificant transfer of glyburide occurs across the human placenta</title><author>Elliott, Byron D. ; Langer, Oded ; Schenker, Steve ; Johnson, Raymond F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-a8469d00b42bbc9b48b076688afb02e18158ddb1bb8581b0941c9edd0b0499493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Biological and medical sciences</topic><topic>diazepam</topic><topic>Diazepam - pharmacokinetics</topic><topic>Female</topic><topic>General and cellular metabolism. Vitamins</topic><topic>Glyburide</topic><topic>Glyburide - pharmacokinetics</topic><topic>Humans</topic><topic>Maternal-Fetal Exchange</topic><topic>Medical sciences</topic><topic>Models, Biological</topic><topic>Pharmacology. Drug treatments</topic><topic>placenta</topic><topic>Placenta - metabolism</topic><topic>Pregnancy</topic><topic>pregnancy, human</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Elliott, Byron D.</creatorcontrib><creatorcontrib>Langer, Oded</creatorcontrib><creatorcontrib>Schenker, Steve</creatorcontrib><creatorcontrib>Johnson, Raymond F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Elliott, Byron D.</au><au>Langer, Oded</au><au>Schenker, Steve</au><au>Johnson, Raymond F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Insignificant transfer of glyburide occurs across the human placenta</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1991-10-01</date><risdate>1991</risdate><volume>165</volume><issue>4</issue><spage>807</spage><epage>812</epage><pages>807-812</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>No data exist concerning human placental transfer of oral hypoglycemic agents during pregnancy. This study characterizes the transport of glyburide in 10 term human placentas with the single-cotyledon placental model. Serial samples were taken from both the maternal and fetal reservoirs during each 3-hour perfusion, and the percent transport and metabolism of tritiated glyburide was calculated with liquid scintillation spectrometry and high-performance liquid chromatography. Antipyrine labeled with carbon 14 was added to the perfusate solution during these experiments as a control. Virtually no transfer of glyburide occurred, and no appreciable metabolism of the drug was detected. Neither variation in the albumin concentration nor increase in the maternal glyburide levels to 100 times therapeutic concentration materially altered the rate of transport. These data show that insignificant transport of glyburide occurs across the human placenta in vitro and suggest that fetal exposure to maternally administered glyburide likewise may be insignificant.</abstract><cop>Philadelphia, PA</cop><pub>Mosby, Inc</pub><pmid>1951536</pmid><doi>10.1016/0002-9378(91)90421-M</doi><tpages>6</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 1991-10, Vol.165 (4), p.807-812 |
| issn | 0002-9378 1097-6868 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Biological and medical sciences diazepam Diazepam - pharmacokinetics Female General and cellular metabolism. Vitamins Glyburide Glyburide - pharmacokinetics Humans Maternal-Fetal Exchange Medical sciences Models, Biological Pharmacology. Drug treatments placenta Placenta - metabolism Pregnancy pregnancy, human |
| title | Insignificant transfer of glyburide occurs across the human placenta |
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