Characterization of Epstein-Barr virus–infected B cells in patients with posttransplantation lymphoproliferative disease: disappearance after rituximab therapy does not predict clinical response

Post-transplantation lymphoproliferative disease (PTLD) is associated with Epstein-Barr virus (EBV). Quantitative and qualitative differences in EBV in peripheral blood mononuclear cells (PBMCs) of PTLD patients and healthy controls were characterized. A quantitative competitive polymerase chain rea...

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Veröffentlicht in:	Blood 2000-12, Vol.96 (13), p.4055-4063
Hauptverfasser:	Yang, Jie, Tao, Qian, Flinn, Ian W., Murray, Paul G., Post, Linda E., Ma, Hong, Piantadosi, Steven, Caligiuri, Michael A., Ambinder, Richard F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antibodies, Monoclonal - therapeutic use Antibodies, Monoclonal, Murine-Derived Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - therapeutic use B-Lymphocyte Subsets - virology Biological and medical sciences Bone marrow, stem cells transplantation. Graft versus host reaction Child Child, Preschool Combined Modality Therapy Disease Progression DNA, Viral - blood Epstein-Barr Virus Infections - blood Epstein-Barr Virus Infections - pathology Female Gene Expression Regulation, Viral Genome, Viral Herpesvirus 4, Human - growth & development Herpesvirus 4, Human - isolation & purification Humans Immunization, Passive Immunosuppression - adverse effects Immunotherapy Lymphocyte Transfusion Lymphoproliferative Disorders - blood Lymphoproliferative Disorders - etiology Lymphoproliferative Disorders - pathology Lymphoproliferative Disorders - therapy Lymphoproliferative Disorders - virology Male Medical sciences Middle Aged Neoplastic Stem Cells - virology Pharmacology. Drug treatments Postoperative Complications - blood Postoperative Complications - etiology Postoperative Complications - pathology Postoperative Complications - therapy Postoperative Complications - virology Prognosis Reverse Transcriptase Polymerase Chain Reaction Rituximab Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Treatment Outcome Tumor Virus Infections - pathology Viral Load Viremia - virology Virus Activation
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