Tyrosine hydroxylase and norepinephrine transporter mRNA expression in the locus coeruleus in Alzheimer’s disease
Despite the loss of locus coeruleus (LC) noradrenergic neurons in Alzheimer’s disease (AD), cerebrospinal fluid norepinephrine (NE) levels are normal or increased in AD. This paradox suggests compensatory upregulation of NE synthetic capacity or downregulation of the NE transporter (NET) in the rema...
Gespeichert in:
| Veröffentlicht in: | Brain research. Molecular brain research. 2000-12, Vol.84 (1), p.135-140 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 140 |
|---|---|
| container_issue | 1 |
| container_start_page | 135 |
| container_title | Brain research. Molecular brain research. |
| container_volume | 84 |
| creator | Szot, Patricia Leverenz, James B Peskind, Elaine R Kiyasu, Elizabeth Rohde, Kirsten Miller, Margaret A Raskind, Murray A |
| description | Despite the loss of locus coeruleus (LC) noradrenergic neurons in Alzheimer’s disease (AD), cerebrospinal fluid norepinephrine (NE) levels are normal or increased in AD. This paradox suggests compensatory upregulation of NE synthetic capacity or downregulation of the NE transporter (NET) in the remaining LC neurons. LC tyrosine hydroxylase (TH) mRNA expression in the LC was measured in AD subjects (
n=5) and in age and gender comparable non-demented subjects (
n=6). When AD subjects were divided into those still ambulatory prior to death (CDR 3/4) and those in a prolonged ‘vegetative’ state prior to death (CDR 5), differences among groups became apparent at specific levels of the LC. In CDR 3/4 AD subjects there was increased TH mRNA expression per neuron compared to non-demented subjects in the caudal half of the LC. However, expression of NET mRNA in the same subjects was not significantly different at any level of the LC. These preliminary results suggest an upregulation of NE biosynthetic capacity in at least some LC neurons in AD prior to the very late stage of the disease. |
| doi_str_mv | 10.1016/S0169-328X(00)00168-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_72474481</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0169328X00001686</els_id><sourcerecordid>72474481</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-aadda7029f755e329a07298a337408ad78960eb0fd859a180459598cc89172663</originalsourceid><addsrcrecordid>eNqFkc9u1DAQxq0KRJfCIxRZQkJwSLETJ7ZPaFUVqFS1EhSJm-XaE61REgdPUnV74jX6en2SerurcqwP_jc_z4y_j5BDzo44483nn3nSRVWq3x8Z-8TySRXNHllwJcui0YK_IIsnZJ-8RvzDMqU4f0X2eR5VLdiC4OU6RQwD0NXap3iz7iwCtYOnQ0ww5sC4SpvwlOyAY0wTJNr_OF9SuBkTIIY40DDQaQW0i25G6iKkuYO8y9fL7nYFoYd0_-8OqQ8IOf0b8rK1HcLb3XpAfn09uTz-XpxdfDs9Xp4VTpRsKqz13kpW6lbWNVSltkyWWtmqkoIp66XSDYMr1npVa8sVE7WutXJOaS7LpqkOyIdt3jHFvzPgZPqADrrODhBnNLIUUgjFnwW5zBWlEhmst6DLomGC1owp9DatDWdmY4t5tMVsNDeMmUdbzKaTd7sC81UP_v-rnQ8ZeL8DLDrbtVlsF_CJU6LJf8rUly0FWbXrAMmgCzA48CGBm4yP4ZlGHgBMgqug</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>17740784</pqid></control><display><type>article</type><title>Tyrosine hydroxylase and norepinephrine transporter mRNA expression in the locus coeruleus in Alzheimer’s disease</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Szot, Patricia ; Leverenz, James B ; Peskind, Elaine R ; Kiyasu, Elizabeth ; Rohde, Kirsten ; Miller, Margaret A ; Raskind, Murray A</creator><creatorcontrib>Szot, Patricia ; Leverenz, James B ; Peskind, Elaine R ; Kiyasu, Elizabeth ; Rohde, Kirsten ; Miller, Margaret A ; Raskind, Murray A</creatorcontrib><description>Despite the loss of locus coeruleus (LC) noradrenergic neurons in Alzheimer’s disease (AD), cerebrospinal fluid norepinephrine (NE) levels are normal or increased in AD. This paradox suggests compensatory upregulation of NE synthetic capacity or downregulation of the NE transporter (NET) in the remaining LC neurons. LC tyrosine hydroxylase (TH) mRNA expression in the LC was measured in AD subjects (
n=5) and in age and gender comparable non-demented subjects (
n=6). When AD subjects were divided into those still ambulatory prior to death (CDR 3/4) and those in a prolonged ‘vegetative’ state prior to death (CDR 5), differences among groups became apparent at specific levels of the LC. In CDR 3/4 AD subjects there was increased TH mRNA expression per neuron compared to non-demented subjects in the caudal half of the LC. However, expression of NET mRNA in the same subjects was not significantly different at any level of the LC. These preliminary results suggest an upregulation of NE biosynthetic capacity in at least some LC neurons in AD prior to the very late stage of the disease.</description><identifier>ISSN: 0169-328X</identifier><identifier>EISSN: 1872-6941</identifier><identifier>DOI: 10.1016/S0169-328X(00)00168-6</identifier><identifier>PMID: 11113540</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Aged ; Aged, 80 and over ; Aging ; Alzheimer Disease - enzymology ; Alzheimer Disease - genetics ; Alzheimer Disease - pathology ; Alzheimer’s disease ; Biological and medical sciences ; Carrier Proteins - genetics ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Female ; Gene Expression ; Humans ; In situ ; In Situ Hybridization ; Locus coeruleus ; Locus Coeruleus - metabolism ; Locus Coeruleus - pathology ; Locus coeruleus lesion ; Male ; Medical sciences ; Neurology ; Neurons - metabolism ; Neurons - pathology ; Norepinephrine Plasma Membrane Transport Proteins ; Norepinephrine transporter ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Symporters ; Tyrosine 3-Monooxygenase - genetics ; Tyrosine hydroxylase</subject><ispartof>Brain research. Molecular brain research., 2000-12, Vol.84 (1), p.135-140</ispartof><rights>2000 Elsevier Science B.V.</rights><rights>2001 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-aadda7029f755e329a07298a337408ad78960eb0fd859a180459598cc89172663</citedby><cites>FETCH-LOGICAL-c420t-aadda7029f755e329a07298a337408ad78960eb0fd859a180459598cc89172663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=846917$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11113540$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Szot, Patricia</creatorcontrib><creatorcontrib>Leverenz, James B</creatorcontrib><creatorcontrib>Peskind, Elaine R</creatorcontrib><creatorcontrib>Kiyasu, Elizabeth</creatorcontrib><creatorcontrib>Rohde, Kirsten</creatorcontrib><creatorcontrib>Miller, Margaret A</creatorcontrib><creatorcontrib>Raskind, Murray A</creatorcontrib><title>Tyrosine hydroxylase and norepinephrine transporter mRNA expression in the locus coeruleus in Alzheimer’s disease</title><title>Brain research. Molecular brain research.</title><addtitle>Brain Res Mol Brain Res</addtitle><description>Despite the loss of locus coeruleus (LC) noradrenergic neurons in Alzheimer’s disease (AD), cerebrospinal fluid norepinephrine (NE) levels are normal or increased in AD. This paradox suggests compensatory upregulation of NE synthetic capacity or downregulation of the NE transporter (NET) in the remaining LC neurons. LC tyrosine hydroxylase (TH) mRNA expression in the LC was measured in AD subjects (
n=5) and in age and gender comparable non-demented subjects (
n=6). When AD subjects were divided into those still ambulatory prior to death (CDR 3/4) and those in a prolonged ‘vegetative’ state prior to death (CDR 5), differences among groups became apparent at specific levels of the LC. In CDR 3/4 AD subjects there was increased TH mRNA expression per neuron compared to non-demented subjects in the caudal half of the LC. However, expression of NET mRNA in the same subjects was not significantly different at any level of the LC. These preliminary results suggest an upregulation of NE biosynthetic capacity in at least some LC neurons in AD prior to the very late stage of the disease.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Alzheimer Disease - enzymology</subject><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer Disease - pathology</subject><subject>Alzheimer’s disease</subject><subject>Biological and medical sciences</subject><subject>Carrier Proteins - genetics</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Female</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>In situ</subject><subject>In Situ Hybridization</subject><subject>Locus coeruleus</subject><subject>Locus Coeruleus - metabolism</subject><subject>Locus Coeruleus - pathology</subject><subject>Locus coeruleus lesion</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neurology</subject><subject>Neurons - metabolism</subject><subject>Neurons - pathology</subject><subject>Norepinephrine Plasma Membrane Transport Proteins</subject><subject>Norepinephrine transporter</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>Symporters</subject><subject>Tyrosine 3-Monooxygenase - genetics</subject><subject>Tyrosine hydroxylase</subject><issn>0169-328X</issn><issn>1872-6941</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2000</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxq0KRJfCIxRZQkJwSLETJ7ZPaFUVqFS1EhSJm-XaE61REgdPUnV74jX6en2SerurcqwP_jc_z4y_j5BDzo44483nn3nSRVWq3x8Z-8TySRXNHllwJcui0YK_IIsnZJ-8RvzDMqU4f0X2eR5VLdiC4OU6RQwD0NXap3iz7iwCtYOnQ0ww5sC4SpvwlOyAY0wTJNr_OF9SuBkTIIY40DDQaQW0i25G6iKkuYO8y9fL7nYFoYd0_-8OqQ8IOf0b8rK1HcLb3XpAfn09uTz-XpxdfDs9Xp4VTpRsKqz13kpW6lbWNVSltkyWWtmqkoIp66XSDYMr1npVa8sVE7WutXJOaS7LpqkOyIdt3jHFvzPgZPqADrrODhBnNLIUUgjFnwW5zBWlEhmst6DLomGC1owp9DatDWdmY4t5tMVsNDeMmUdbzKaTd7sC81UP_v-rnQ8ZeL8DLDrbtVlsF_CJU6LJf8rUly0FWbXrAMmgCzA48CGBm4yP4ZlGHgBMgqug</recordid><startdate>20001208</startdate><enddate>20001208</enddate><creator>Szot, Patricia</creator><creator>Leverenz, James B</creator><creator>Peskind, Elaine R</creator><creator>Kiyasu, Elizabeth</creator><creator>Rohde, Kirsten</creator><creator>Miller, Margaret A</creator><creator>Raskind, Murray A</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>20001208</creationdate><title>Tyrosine hydroxylase and norepinephrine transporter mRNA expression in the locus coeruleus in Alzheimer’s disease</title><author>Szot, Patricia ; Leverenz, James B ; Peskind, Elaine R ; Kiyasu, Elizabeth ; Rohde, Kirsten ; Miller, Margaret A ; Raskind, Murray A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-aadda7029f755e329a07298a337408ad78960eb0fd859a180459598cc89172663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2000</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Alzheimer Disease - enzymology</topic><topic>Alzheimer Disease - genetics</topic><topic>Alzheimer Disease - pathology</topic><topic>Alzheimer’s disease</topic><topic>Biological and medical sciences</topic><topic>Carrier Proteins - genetics</topic><topic>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</topic><topic>Female</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>In situ</topic><topic>In Situ Hybridization</topic><topic>Locus coeruleus</topic><topic>Locus Coeruleus - metabolism</topic><topic>Locus Coeruleus - pathology</topic><topic>Locus coeruleus lesion</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neurology</topic><topic>Neurons - metabolism</topic><topic>Neurons - pathology</topic><topic>Norepinephrine Plasma Membrane Transport Proteins</topic><topic>Norepinephrine transporter</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>Symporters</topic><topic>Tyrosine 3-Monooxygenase - genetics</topic><topic>Tyrosine hydroxylase</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Szot, Patricia</creatorcontrib><creatorcontrib>Leverenz, James B</creatorcontrib><creatorcontrib>Peskind, Elaine R</creatorcontrib><creatorcontrib>Kiyasu, Elizabeth</creatorcontrib><creatorcontrib>Rohde, Kirsten</creatorcontrib><creatorcontrib>Miller, Margaret A</creatorcontrib><creatorcontrib>Raskind, Murray A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research. Molecular brain research.</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Szot, Patricia</au><au>Leverenz, James B</au><au>Peskind, Elaine R</au><au>Kiyasu, Elizabeth</au><au>Rohde, Kirsten</au><au>Miller, Margaret A</au><au>Raskind, Murray A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tyrosine hydroxylase and norepinephrine transporter mRNA expression in the locus coeruleus in Alzheimer’s disease</atitle><jtitle>Brain research. Molecular brain research.</jtitle><addtitle>Brain Res Mol Brain Res</addtitle><date>2000-12-08</date><risdate>2000</risdate><volume>84</volume><issue>1</issue><spage>135</spage><epage>140</epage><pages>135-140</pages><issn>0169-328X</issn><eissn>1872-6941</eissn><abstract>Despite the loss of locus coeruleus (LC) noradrenergic neurons in Alzheimer’s disease (AD), cerebrospinal fluid norepinephrine (NE) levels are normal or increased in AD. This paradox suggests compensatory upregulation of NE synthetic capacity or downregulation of the NE transporter (NET) in the remaining LC neurons. LC tyrosine hydroxylase (TH) mRNA expression in the LC was measured in AD subjects (
n=5) and in age and gender comparable non-demented subjects (
n=6). When AD subjects were divided into those still ambulatory prior to death (CDR 3/4) and those in a prolonged ‘vegetative’ state prior to death (CDR 5), differences among groups became apparent at specific levels of the LC. In CDR 3/4 AD subjects there was increased TH mRNA expression per neuron compared to non-demented subjects in the caudal half of the LC. However, expression of NET mRNA in the same subjects was not significantly different at any level of the LC. These preliminary results suggest an upregulation of NE biosynthetic capacity in at least some LC neurons in AD prior to the very late stage of the disease.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><pmid>11113540</pmid><doi>10.1016/S0169-328X(00)00168-6</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0169-328X |
| ispartof | Brain research. Molecular brain research., 2000-12, Vol.84 (1), p.135-140 |
| issn | 0169-328X 1872-6941 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_72474481 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Aged Aged, 80 and over Aging Alzheimer Disease - enzymology Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer’s disease Biological and medical sciences Carrier Proteins - genetics Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Female Gene Expression Humans In situ In Situ Hybridization Locus coeruleus Locus Coeruleus - metabolism Locus Coeruleus - pathology Locus coeruleus lesion Male Medical sciences Neurology Neurons - metabolism Neurons - pathology Norepinephrine Plasma Membrane Transport Proteins Norepinephrine transporter RNA, Messenger - genetics RNA, Messenger - metabolism Symporters Tyrosine 3-Monooxygenase - genetics Tyrosine hydroxylase |
| title | Tyrosine hydroxylase and norepinephrine transporter mRNA expression in the locus coeruleus in Alzheimer’s disease |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T11%3A52%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Tyrosine%20hydroxylase%20and%20norepinephrine%20transporter%20mRNA%20expression%20in%20the%20locus%20coeruleus%20in%20Alzheimer%E2%80%99s%20disease&rft.jtitle=Brain%20research.%20Molecular%20brain%20research.&rft.au=Szot,%20Patricia&rft.date=2000-12-08&rft.volume=84&rft.issue=1&rft.spage=135&rft.epage=140&rft.pages=135-140&rft.issn=0169-328X&rft.eissn=1872-6941&rft_id=info:doi/10.1016/S0169-328X(00)00168-6&rft_dat=%3Cproquest_cross%3E72474481%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=17740784&rft_id=info:pmid/11113540&rft_els_id=S0169328X00001686&rfr_iscdi=true |