Adhesion mediated by LFA‐1 is required for efficient IL‐12‐induced NK and NKT cell cytotoxicity

Interleukin 12 (IL‐12)‐activated NK1.1+TCRα β+ (NKT2) and NK1.1+TCRα β– (NK) cells exhibit cytotoxic activity against a wide variety of tumor cells in the absence of prior sensitization. Here we demonstrate that the integrin adhesion receptor LFA‐1 (CD11a / CD18) regulates the cytotoxic activity of...

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Veröffentlicht in:	European journal of immunology 2000-12, Vol.30 (12), p.3723-3731
Hauptverfasser:	Matsumoto, Goichi, Omi, Yasushi, Lee, Ushaku, Nishimura, Takashi, Shindo, Junichi, Penninger, Josef M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens - analysis Antigens, Ly Antigens, Surface Cell Adhesion Cytotoxicity Cytotoxicity, Immunologic Fas Ligand Protein IL‐12 Interleukin-12 - pharmacology Killer Cells, Natural - immunology Killer Cells, Natural - physiology Lectins, C-Type LFA-1 antigen LFA‐1 Lymphocyte Function-Associated Antigen-1 - physiology Membrane Glycoproteins - analysis Mice Mice, Inbred C57BL NK Cell Lectin-Like Receptor Subfamily B NK T cell Perforin Pore Forming Cytotoxic Proteins Proteins - analysis Receptors, Antigen, T-Cell, alpha-beta - analysis
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