Calcineurin Blockade Prevents Cardiac Mitogen-activated Protein Kinase Activation and Hypertrophy in Renovascular Hypertension

Chronic stimulation of the renin-angiotensin system induces an elevation of blood pressure and the development of cardiac hypertrophy via the actions of its effector, angiotensin II. In cardiomyocytes, mitogen-activated protein kinases as well as protein kinase C isoforms have been shown to be impor...

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Veröffentlicht in:	The Journal of biological chemistry 2000-12, Vol.275 (52), p.40867-40873
Hauptverfasser:	Murat, Anastasia, Pellieux, Corinne, Brunner, Hans-R., Pedrazzini, Thierry
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin II - pharmacology Animals Calcineurin - physiology Calcineurin Inhibitors Cardiomegaly - prevention & control Cyclosporine - pharmacology Enzyme Activation Hypertension, Renovascular - complications Male Mice Mice, Inbred C57BL Mitogen-Activated Protein Kinases - metabolism Myocardium - enzymology Protein Kinase C - physiology
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