Effect of Antioxidant Therapy on Blood Pressure and NO Synthase Expression in Hypertensive Rats

Earlier studies have demonstrated evidence for increased reactive oxygen species, enhanced NO synthase (NOS) expression, and elevated NO production in spontaneously hypertensive rats (SHR). Given the negative-feedback regulation of NOS by NO, we hypothesized that enhanced NO inactivation by ROS may...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2000-12, Vol.36 (6), p.957-964
Hauptverfasser:	Vaziri, Nosratola D, Ni, Zhenmin, Oveisi, Fariba, Trnavsky-Hobbs, Debra L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - therapeutic use Aorta - drug effects Aorta - enzymology Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blood Pressure - drug effects Brain - drug effects Brain - enzymology Cardiology. Vascular system Disease Models, Animal Experimental diseases Free Radicals - metabolism Heart - drug effects Hypertension - drug therapy Hypertension - enzymology Hypertension - physiopathology Isoenzymes - biosynthesis Kidney - drug effects Kidney - enzymology Male Medical sciences Nitric Oxide - metabolism Nitric Oxide Synthase - biosynthesis Rats Rats, Inbred SHR Rats, Inbred WKY
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